510 citations
,
August 2006 in “Endocrinology” The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.
479 citations
,
June 2014 in “Science” Epithelial stem cells can adapt and help in tissue repair and regeneration.
426 citations
,
August 2014 in “Nature Medicine” Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
218 citations
,
April 2008 in “Genes & Development” Skin stem cells help repair damage and maintain healthy skin.
187 citations
,
December 2005 in “Experimental Dermatology” Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.
172 citations
,
May 2018 in “Nature” Mammalian organs regenerate using stem cells and cell plasticity, but this ability declines with age.
172 citations
,
July 2007 in “Journal of Dermatological Science” Stat3 helps skin heal but can also cause skin diseases if overactive.
169 citations
,
February 2018 in “Immunity” Inactive stem cells in hair follicles and muscles can avoid detection by the immune system.
158 citations
,
November 1998 in “Cell” β-catenin affects hair growth and can lead to tumors, needing more research for better understanding.
153 citations
,
October 2012 in “Skin Pharmacology and Physiology” Caffeine in cosmetics may reduce cellulite, protect skin, and stimulate hair growth, but more research is needed on its use and effects.
142 citations
,
March 2019 in “Molecules/Molecules online/Molecules annual” Cannabinoids may help treat various skin conditions.
139 citations
,
February 2014 in “Journal of Advanced Research” Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.
99 citations
,
August 2009 in “Nature Genetics” Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.
97 citations
,
September 2006 in “Pharmaceutical Research” No treatment fully prevents hair loss from chemotherapy yet.
66 citations
,
July 2015 in “Organogenesis” Wnt signaling is crucial for skin wound healing and reducing scars.
63 citations
,
March 2018 in “Experimental Dermatology” Collagen XVII is vital for skin structure, hair stem cell support, and skin cell regulation.
60 citations
,
June 1997 in “Journal of The American Academy of Dermatology” Apoptosis is crucial for healthy skin and treating skin diseases.
57 citations
,
November 2017 in “Nature Communications” Researchers found 71 genetic regions linked to male pattern baldness, which account for 38% of its genetic risk.
57 citations
,
January 2004 in “Journal of Radiation Research” Zinc sulphate may help reduce skin damage from radiation therapy.
42 citations
,
May 2016 in “Annual Review of Cell and Developmental Biology” Fat cells are important for tissue repair and stem cell support in various body parts.
39 citations
,
January 2016 in “PubMed” Understanding how EDC genes are regulated can help develop better drugs for skin diseases.
37 citations
,
July 2016 in “Current Opinion in Cell Biology” Live imaging has advanced our understanding of stem cell behavior and raised new research questions.
35 citations
,
July 2022 in “Frontiers in Cell and Developmental Biology” Proper mTOR signaling is crucial for healthy skin and preventing skin diseases.
34 citations
,
January 2013 in “Frontiers in genetics” Stem cells can help other stem cells by producing supportive factors.
33 citations
,
October 2004 in “Archives of Dermatological Research” Large prostate links to more hair loss, but age of onset doesn't affect it.
30 citations
,
April 2010 in “Cell Cycle” The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.
26 citations
,
February 2021 in “FEBS Journal” Targeting regulatory T cells may help treat age-related diseases.
24 citations
,
September 2023 in “Science Advances” Mettl3 is essential for normal tissue development and self-renewal by regulating gene expression.
23 citations
,
October 2021 in “FEBS Journal” Sonic Hedgehog helps keep skin and airway barriers healthy and reduces inflammation.
23 citations
,
May 2013 in “Virology” HPV16 oncogenes disrupt the normal activity of hair follicle stem cells.