research Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation
Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
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research Regulatory effect of β-catenin on proliferation of hair follicle stem cells involves PI3K/Akt pathway
β-catenin helps hair follicle stem cells grow by activating a specific cell pathway.
research Convergent Genesis of an Adult Neural Crest-Like Dermal Stem Cell from Distinct Developmental Origins
Skin-derived precursors in hair follicles come from different origins but function similarly.
research Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model
Removing certain hair follicle stem cells worsens skin reactions to allergens.
research INTRODUCING OPTICAL MICROSCOPY METHODOLOGY DISPLAYING EMITTED ELECTROMAGNETIC ENERGY OF PRE-CANCEROUS SKIN SQUAMOUS CELL CARCINOMA
The new microscope method helps study energy from pre-cancerous skin cells.
research Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway
Gsdma3 affects hair growth by controlling Wnt5a, which influences hair cell development.
research Reconstructed human skin shows epidermal invagination towards integrated neopapillae indicating early hair follicle formation in vitro
The experiment showed that human skin grown in the lab started to form early hair structures when special cell clusters were added.
research TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis
TCF/Lef1 activity is essential for proper skin cell development and renewal.
research Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation
Understanding how certain proteins and genetic changes control skin stem cells is key to treating skin diseases.
research POLYCOMB REPRESSIVE COMPLEX 1 IS REQUIRED TO MAINTAIN STEM CELL IDENTITY AND TO PRESERVE ADULT TISSUE HOMEOSTASIS.
Polycomb Repressive Complex 1 is crucial for keeping stem cells stable and maintaining healthy adult tissues.
research Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately
Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.
research Fondation René Touraine
The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.
research More than one way to skin . . .
Skin stem cells help repair damage and maintain healthy skin.
research The Fate of Trichohyalin
Trichohyalin is modified by enzymes to form strong structures in hair cells.
research The Proximal Promoter of the Human Transglutaminase 3 Gene
The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.
research PI3K/Akt signaling pathway is essential for de novo hair follicle regeneration
PI3K/Akt pathway is crucial for hair growth and regeneration.
research Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation
The lentiviral array can monitor and predict gene activity during stem cell differentiation.
research Editors' Picks
Small molecule DMF improves psoriasis and multiple sclerosis, adult skin cells can be made to grow new hair, certain skin cells initiate hair growth, IL-17C controls gut health and can cause skin inflammation, and skin cells produce IL-17 that can lead to psoriasis.
research Organ regeneration based on developmental biology: past and future
Scientists have made progress in growing mini-organs and regenerating parts of the skin, with plans to treat hair loss in a future trial.
research Thymic stromal lymphopoietin controls hair growth
Thymic stromal lymphopoietin (TSLP) promotes hair growth, especially after skin injury.
research RANK as a therapeutic target in cancer
RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.
research Live imaging of stem cells: answering old questions and raising new ones
Live imaging has advanced our understanding of stem cell behavior and raised new research questions.
research An Ovol2‐Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation
The Ovol2-Zeb1 circuit is crucial for skin healing and hair growth by guiding cell movement and growth.
research Genetic Tools for Cell Lineage Tracing and Profiling Developmental Trajectories in the Skin
CRISPR-based tools improve understanding and treatment of skin development and conditions.
research Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus
The conclusion is that Pigmented Epithelioid Melanocytoma can start from hair follicle stem cells or from a mole on the skin.
research SOX2 in the Skin
SOX2 is crucial for skin cell function and hair growth, and it plays a role in skin cancer and wound healing.
research Deciphering the cellular landscape and genetic underpinnings of fiber diameter determined by dermal papilla cells in fine-wool sheep
Dermal papilla cells are key to fine wool growth in sheep.
research Hair regeneration: Mechano-activation and related therapeutic approaches.
Mechanical stimulation and new therapies show promise for hair regrowth.
research Hairy Math: Addition of Wnt-3a to Multiply Bulge Cells
Wnt-3a helps grow more skin stem cells, which could lead to new hair loss treatments.
research Faculty Opinions recommendation of Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation.
A balance between BMP and Wnt signals is crucial for hair follicle stem cell function and hair growth.