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GlossaryHair Follicle Differentiation

process where hair follicle cells become specialized structures

Hair follicle differentiation is the process by which cells within the hair follicle develop into specialized cell types that form the various structures of the hair, such as the hair shaft, inner root sheath, and outer root sheath. This process is crucial for the growth and maintenance of healthy hair, involving a complex interplay of genetic, molecular, and environmental factors.

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research Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia.

219 citations , July 1995 in “PubMed”

Keratinocyte growth factor promotes hair growth and reduces hair loss from chemotherapy.

research Hair follicle differentiation and regulation.

199 citations , January 2004 in “The International Journal of Developmental Biology”

Hair follicle growth and development are controlled by specific genes and molecular signals.

research Dlx3 is a crucial regulator of hair follicle differentiation and cycling

132 citations , August 2008 in “Development”

Dlx3 is essential for hair growth and regeneration.

research The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

127 citations , January 2008 in “PloS one”

Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.

research Regulation of Keratin Gene Expression in Hair Follicle Differentiation^a

98 citations , December 1991 in “Annals of the New York Academy of Sciences”

Keratin gene regulation is similar across mammals, affecting hair follicle differentiation.

research Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation

79 citations , December 1999 in “Mechanisms of Development”

Whn is crucial for hair growth in certain areas by controlling a specific gene.

research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation

68 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

HOXC13 is essential for hair and nail development by regulating Foxn1.

Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

research Evidence That the Satin Hair Mutant Gene Foxq1 Is among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 during Hair Follicle Differentiation

65 citations , July 2006 in “Journal of biological chemistry/The Journal of biological chemistry”

The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.

research Hair follicle differentiation: expression, structure and evolutionary conservation of the hair type II keratin intermediate filament gene family

65 citations , February 1992 in “Development”

Type II keratin genes are crucial for hair follicle differentiation and have a conserved structure and expression pattern.

research Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling

65 citations , September 2004 in “The American journal of pathology”

Blocking BMP signaling causes hair loss and disrupts hair growth cycles.

research Hair follicle differentiation‐specific keratin expression in human basal cell carcinoma

45 citations , October 2019 in “Clinical and Experimental Dermatology”

Targeted therapies promoting differentiation could help treat basal cell carcinoma by exhausting cancer stem cells.

research Gsdma3 is required for hair follicle differentiation in mice

30 citations , October 2010 in “Biochemical and biophysical research communications”

The Gsdma3 gene is essential for normal hair development in mice.

research Characterization of a gene encoding a cysteine-rich keratin associated protein synthesized late in rabbit hair follicle differentiation

26 citations , March 1995 in “Differentiation”

A rabbit gene important for hair development was identified and detailed.

research Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation

19 citations , September 2007 in “The Journal of Steroid Biochemistry and Molecular Biology”

Glucocorticoid receptors help regulate genes important for skin health and hair growth.

research iRhom2 Mutation Leads to Aberrant Hair Follicle Differentiation in Mice

15 citations , December 2014 in “PLoS ONE”

A mutation in the iRhom2 gene causes hairless mice due to abnormal hair follicle development.

research Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway

11 citations , October 2017 in “Oncotarget”

Gsdma3 affects hair growth by controlling Wnt5a, which influences hair cell development.

CircRNA-0100 Positively Regulates the Differentiation of Cashmere Goat SHF-SCs into Hair Follicle Lineage via Sequestering miR-153-3p to Heighten the KLF5 Expression

research CircRNA-0100 positively regulates the differentiation of cashmere goat SHF-SCs into hair follicle lineage via sequestering miR-153-3p to heighten the KLF5 expression

9 citations , February 2022 in “Archives animal breeding/Archiv für Tierzucht”

A circular RNA helps cashmere goat hair cells become hair follicles by blocking a molecule to boost a gene important for hair growth.

research Using High-Throughput Immunoblotting to Identify Proteins Involved in the Differentiation of ES Cells along the Hair Follicle Lineage in Vitro

4 citations , April 2011 in “Stem Cell Reviews and Reports”

The research helps understand how stem cells turn into hair follicle cells.

research Effects of RF Electric Currents on Hair Follicle Growth and Differentiation: A Possible Treatment for Alopecia

July 2024 in “International Journal of Molecular Sciences”

RF-based therapies might help treat hair loss.

research Claudin tight junctionwhat's your function? The role of Claudin 6 in epidermal and hair follicle differentiation

January 2004 in “uO Research (University of Ottawa)”

Claudin 6 is crucial for normal skin and hair development.

research ES Cell Differentiation Into the Hair Follicle Lineage In Vitro

13 citations , November 2003 in “Humana Press eBooks”

ES cells can be turned into hair follicle cells in a lab setting.

research Colocalization of Cystatin M/E and its Target Proteases Suggests a Role in Terminal Differentiation of Human Hair Follicle and Nail

22 citations , November 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Cystatin M/E helps in the final stages of hair and nail formation by controlling certain enzymes.

research A Potential Differentiation of Adipose and Hair Follicle-derived Mesenchymal Stem Cells to Generate Neurons Induced with EGF, FGF, PDGF and Forskolin

14 citations , January 2020 in “Research Journal of Pharmacy and Technology”

Fat and hair follicle stem cells can become neurons, useful for treating brain diseases.

research In vitro Differentiation of Hair Follicle Stem Cell into Keratinocyte by Simvastatin

10 citations , October 2019 in “Iranian Biomedical Journal”

Simvastatin helps hair follicle stem cells turn into skin cells.

research In Vitro differentiation of hair-follicle bulge stem cells into synaptophysin-expressing neurons: a potential new approach for neuro-regeneration

November 2024 in “Human Cell”

Hair follicle stem cells can be turned into neuron-like cells, offering a new way for brain repair.

research Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle

305 citations , December 2000 in “The EMBO Journal”

Inhibiting Bmp signaling disrupts hair growth and differentiation.

research Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients

198 citations , June 2013 in “Molecular psychiatry”

Schizophrenia patients' stem cells show abnormal neuron development and mitochondrial issues.

Clonal Multipotency and Effect of Long-Term In Vitro Expansion on Differentiation Potential of Human Hair Follicle Derived Mesenchymal Stem Cells

research Clonal multipotency and effect of long-term in vitro expansion on differentiation potential of human hair follicle derived mesenchymal stem cells

73 citations , August 2011 in “Stem Cell Research”

Human hair follicle stem cells can turn into multiple cell types but lose some of this ability after being grown in the lab for a long time.

research VEGF165 induces differentiation of hair follicle stem cells into endothelial cells and plays a role in in vivo angiogenesis

36 citations , February 2017 in “Journal of Cellular and Molecular Medicine”

VEGF165 helps hair follicle stem cells become blood vessel cells, aiding new blood vessel growth.

research Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold

29 citations , April 2020 in “Biomolecules”

The 3D scaffold helped maintain hair cell traits and could improve hair loss treatments.