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GlossaryHair Follicle Loss

permanent destruction or degeneration of hair-producing skin structures

Hair Follicle Loss refers to the permanent destruction or degeneration of hair follicles, which are the small structures in the skin responsible for hair growth. This condition can result from various factors, including genetic predisposition, autoimmune disorders like alopecia areata, or physical damage to the scalp. Once hair follicles are lost, they typically cannot regenerate, leading to permanent hair loss in the affected areas.

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research Do we need hair follicle stem cells and hair follicle neogenesis to cure common hair loss disorders?

3 citations , May 2008 in “Hair transplant forum international”

Common hair loss disorders may not need stem cell therapy, but could benefit from other treatments like hair cycle control and immune restoration therapy.

Pattern Hair Loss: Assessment of Microinflammation in Miniaturized and Terminal Hair Follicles Through Horizontal Histologic Sections

research Pattern hair loss: Assessment of microinflammation in miniaturized and terminal hair follicles through horizontal histologic sections

11 citations , April 2020 in “Journal of The American Academy of Dermatology”

Microinflammation is more intense in smaller hair follicles and may be linked to hair loss.

research Unraveling the secret life of the hair follicle: from fungi to innovative hair loss therapies

10 citations , June 2017 in “Experimental Dermatology”

New hair loss treatments have evolved from understanding hair biology and patient needs.

Sulfotransferase Activity in Plucked Hair Follicles Predicts Response to Topical Minoxidil Treatment in Brazilian Female Pattern Hair Loss Patients

research Sulfotransferase activity in plucked hair follicles predicts response to topical minoxidil treatment in Brazilian female pattern hair loss patients

4 citations , December 2019 in “Dermatologic Therapy”

Hair enzyme activity predicts minoxidil success in Brazilian women with hair loss.

research Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview

1 citations , December 2023 in “Biomolecules”

Regulating cell death in hair follicles can help prevent hair loss and promote hair growth.

research Strategies to utilize iPS cells for hair follicle regeneration and the treatment of hair loss disorders

January 2021 in “Elsevier eBooks”

hiPSCs can help regenerate hair follicles and treat hair loss.

research Hair Follicle Classification and Hair Loss Severity Estimation Using Mask R-CNN

4 citations , October 2022 in “Journal of Imaging”

An intelligent system can classify hair follicles and measure hair loss severity with reasonable accuracy.

Anti-Hair Loss Activity of Healthy Human Scalp-Derived Staphylococcus Capitis KMH304 Ferment Filtrate in Human Hair-Follicle Dermal Papilla and Keratinocyte Cells

research Anti-Hair Loss Activity of Healthy Human Scalp-Derived Staphylococcus capitis KMH304 Ferment Filtrate in Human Hair-Follicle Dermal Papilla and Keratinocyte Cells

April 2026 in “Microorganisms”

SCFF may help promote hair growth and scalp health.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression (Catagen) by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations , June 2005 in “Journal of Investigative Dermatology”

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

research Stem cells from human hair follicles: first mechanical isolation for immediate autologous clinical use in androgenetic alopecia and hair loss

86 citations , June 2017 in “Stem cell investigation”

Stem cells from hair follicles can safely treat hair loss.

research Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles

47 citations , May 1995 in “Journal of Investigative Dermatology”

Hair follicles in people with alopecia have lower levels of a key blood vessel growth protein.

research Apoptosis in follicles of individuals with female pattern hair loss is associated with perifollicular microinflammation

30 citations , May 2016 in “International Journal of Cosmetic Science”

Hair loss in women links to inflammation around hair follicles.

research Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.

26 citations , June 2003 in “PubMed”

Alpha-difluoromethylornithine prevents cancer in mice but causes hair loss.

Oral Minoxidil Bio-Activation by Hair Follicle Outer Root Sheath Cell Sulfotransferase Enzymes Predicts Clinical Efficacy in Female Pattern Hair Loss

research Oral minoxidil bio‐activation by hair follicle outer root sheath cell sulfotransferase enzymes predicts clinical efficacy in female pattern hair loss

9 citations , August 2019 in “Journal of The European Academy of Dermatology and Venereology”

Minoxidil activation by hair enzymes predicts treatment success for female hair loss.

Maintenance of Optimized Hair Growth from Viable Terminal Scalp Hair Follicles at Baseline with Oral Finasteride in Male Pattern Hair Loss and First Evidence of a Drug Dependency and a Post-Finasteride Rebound Effect

research Maintenance of optimised hair growth from viable terminal scalp hair follicles at baseline with oral finasteride in male pattern hair loss and first evidence of a “drug dependency” and a post-finasteride “rebound effect”.

4 citations , May 2019 in “Skin Research and Technology”

Finasteride helps hair growth but stopping it causes faster hair loss.

research Characterization of Hair Follicles in Hirosaki Hairless Rats with Deletion of Basic Hair Keratin Genes. Enlarged Medulla, Loss of Cuticle and Long Catagen

3 citations , March 2009 in “Hirosaki University Repository for Academic Resources (Hirosaki University)”

Hirosaki hairless rats have sparse, twisted hair due to missing hair keratin genes.

research Hair Loss Treatment Uses Stem Cells to Generate Healthy New Follicles

June 2022 in “Genetic engineering & biotechnology news”

A new hair loss treatment is being developed using reprogrammed stem cells to grow new hair follicles.

Hair Loss Improvement Effect of Chrysanthemum Zawadskii, Peppermint, and Glycyrrhiza Glabra Herbal Mixture in Human Follicle Dermal Papilla Cells and C57BL/6 Mice

research Hair loss improvement effect of Chrysanthemum zawadskii, peppermint and Glycyrrhiza glabra herbal mixture in human follicle dermal papilla cell and C57BL/6 mice

January 2022 in “Food Science and Technology”

The herbal mixture could potentially improve hair loss.

research HAIR LOSS ASSOCIATED WITH ESCITALOPRAM: DO SSRIs AFFECT MELATONIN AT THE HAIR FOLLICLE?

June 2021 in “Psychiatria Danubina”

The antidepressant escitalopram likely caused hair loss in a patient.

research 905 Dysfunction of hair follicle mesenchymal progenitors is associated with age-related hair loss

May 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Age-related hair loss is linked to the decline and dysfunction of hair follicle stem cells.

Poor Perifollicular Vascularization Is Associated With Nutrient Insufficiency and a Quiescent Metabolic Phenotype in Intermediate Hair Follicles From Patients With Female Pattern Hair Loss

research 333 Poor perifollicular vascularization is associated with nutrient insufficiency and a quiescent metabolic phenotype in intermediate hair follicles from patients with female pattern hair loss

October 2021 in “Journal of Investigative Dermatology”

Poor blood supply in hair follicles is linked to nutrient deficiency in patients with female pattern hair loss, and adding more nutrients could potentially fix this.

Resident T Cell Activation Leads to Human Hair Follicle Immune Privilege Loss Ex Vivo, Which Is Prevented by the DHODH Inhibitor Farudodstat: Relevance for Alopecia Areata

research Resident T cell activation leads to human hair follicle immune privilege loss ex vivo, which is prevented by the DHODH inhibitor farudodstat: relevance for alopecia areata

April 2026 in “Frontiers in Medicine”

Farudodstat may help prevent hair loss in alopecia areata by stopping immune attacks on hair follicles.

research Responses of hair follicle–associated structures to loss of planar cell polarity signaling

29 citations , February 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Loss of Fz6 disrupts hair follicle and associated structures' orientation.

Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles

research Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles

68 citations , May 2018 in “PLOS Biology”

Cyclosporine A may help treat hair loss by blocking a protein that inhibits hair growth.

research Pten loss in Lgr5⁺ hair follicle stem cells promotes SCC development

24 citations , January 2019 in “Theranostics”

Loss of Pten in certain hair follicle stem cells increases skin cancer risk.

Regenerative Medicine and Hair Loss: How Hair Follicle Culture Has Advanced Our Understanding of Treatment Options for Androgenetic Alopecia

research Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia

23 citations , December 2013 in “Regenerative Medicine”

Hair follicle culture helps develop new treatments for hair loss.

research Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells

20 citations , October 2017 in “Stem Cell Reports”

Alkaline Ceramidase 1 prevents early hair loss in mice by keeping hair follicle stem cells balanced.

research Loss of Gata6 causes dilation of the hair follicle canal and sebaceous duct

16 citations , July 2018 in “Experimental Dermatology”

Removing Gata6 causes hair follicle and sebaceous duct enlargement.

research Diseases on Hair Follicles Leading to Hair Loss Part I: Nonscarring Alopecias

13 citations , July 2004 in “Skinmed”

Common types of non-scarring hair loss have various causes and treatments, but more effective solutions are needed.