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Did you mean Outer Root Sheath Keratinocytes?

GlossaryOuter Root Sheath Keratinocytes

specialized cells in the hair follicle's outer layer

Outer Root Sheath Keratinocytes are specialized cells found in the outer layer of the hair follicle. These cells play a crucial role in the growth and regeneration of hair, as they provide structural support and contribute to the formation of the hair shaft. For professionals, it's important to note that these keratinocytes are involved in the hair cycle's anagen (growth) phase and can be a focus in studies related to hair loss and treatments for conditions like alopecia.

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research Epithelial–mesenchymal transition in keloid tissues and TGF‐β1–induced hair follicle outer root sheath keratinocytes

46 citations , July 2015 in “Wound repair and regeneration”

Keloid scars may form due to changes in skin cell characteristics and specific protein signaling.

research Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells

31 citations , December 1991 in “Annals of the New York Academy of Sciences”

ORS and hair matrix cells balance growth and differentiation better than normal keratinocytes, with human dermal fibroblasts crucial for proper differentiation.

research Sex hormones and antiandrogens influence in vitro growth of dermal papilla cells and outer root sheath keratinocytes of human hair follicles

9 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Sex hormones and antiandrogens can either stimulate or inhibit human hair follicle cell growth depending on the dose.

Nestin as a Marker of Unipotent Epithelial Progenitor Cells Differentiating into Outer Root Sheath Keratinocytes in Embryonic and Adult Hair Follicles

research Nestin as a marker of unipotent epithelial progenitor cells differentiate into outer root sheath keratinocytes in embryonic and adult hair follicles

June 2022 in “Research Square (Research Square)”

Nestin-expressing cells turn into a specific type of skin cell in hair follicles during development and in adults.

Nestin as a Marker of Unipotent Epithelial Progenitor Cell Differentiation into Outer Root Sheath Keratinocytes in Embryonic and Adult Hair Follicles

research Nestin as a marker of unipotent epithelial progenitor cell differentiation into outer root sheath keratinocytes in embryonic and adult hair follicles

May 2022 in “Research Square (Research Square)”

Nestin marks cells that can become a specific type of skin cell in hair follicles of both developing and adult mice.

research Sex Hormones and Antiandro Growth of Dermal Papilla H ens Influence In Vitro Ce Is and Outer Root Sheath Keratinocytes of Human Hair Follicles

January 1993

Testosterone and dihydrotestosterone can slow down the growth of certain hair follicle cells.

research Sulfated hyaluronan‐containing artificial extracellular matrices promote proliferation of keratinocytes and melanotic phenotype of melanocytes from the outer root sheath of hair follicles

8 citations , March 2019 in “Journal of Biomedical Materials Research Part A”

Sulfated hyaluronan in collagen helps hair follicle cells grow and develop better for skin grafts.

Hair Strengthening Evaluation of Anisotropic Osmolyte Solutions (Inositol + Arginine): Cross-Talk Between Dermal Papilla Fibroblast and Keratinocytes of the Outer Root Sheath Using a Micro Hair Follicle 3D Model

research Hair Strengthening Evaluation of Anisotropic Osmolite Solutions (Inositol + Arginine): Cross-Talk between Dermal Papilla Fibroblast and Keratinocytes of the Outer Root Sheath Using a µHair Follicle 3D Model

September 2018 in “Cosmetics”

Inositol and arginine solutions improve hair follicle health and turnover.

research An osteopontin‐derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor‐7 production in outer root sheath keratinocytes

19 citations , September 2019 in “British Journal of Dermatology”

FOL-005 peptide can reduce human hair growth by lowering FGF7 levels.

research Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro

135 citations , November 1987 in “Differentiation”

Outer root sheath cells consistently express certain keratins influenced by their environment.

research Epidermis reconstructed from the outer root sheath of human hair follicle. Effect of retinoic acid

18 citations , June 1993 in “Archives of Dermatological Research”

Human hair follicles can be used to create skin-like tissue for wound healing and drug testing.

research [An immunohistochemical study on cell differentiation in the outer root sheath of the normal human anagen hair follicles with antikeratin monoclonal antibodies].

6 citations , December 1990 in “PubMed”

Keratinocytes in hair follicles differentiate similarly to skin cells, with specific patterns in different regions.

research A new in vitro culture system to produce a fully differentiated epidermis from human hair follicle outer root sheath cells

2 citations , January 1989

Researchers developed a method to grow skin-like tissue from hair cells.

research Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle

107 citations , May 1999 in “Archives of Dermatological Research”

Basal cell carcinoma may start from parts of tiny hair follicles.

Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

research Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair folliclesin vitro

60 citations , May 2014 in “British Journal of Dermatology”

Caffeine affects hair growth and health differently in men and women.

research Progenitor cells expressing nestin, a neural crest stem cell marker, differentiate into outer root sheath keratinocytes

12 citations , July 2019 in “Veterinary Dermatology”

Nestin-expressing progenitor cells become outer root sheath keratinocytes.

research Urokinase plasminogen activator (uPA) is a positive regulator of outer root sheath keratinocyte proliferation

2 citations , July 2004 in “Cell Biology International”

uPA helps hair follicle cells grow.

research Cholesterol homeostasis in hair follicle keratinocytes is disrupted by impaired ABCA5 activity

June 2023 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

Impaired ABCA5 activity disrupts cholesterol balance in hair follicle cells, affecting hair growth.

research Growth of human hair follicle keratinocytes in vitro

28 citations , November 1987 in “Journal of the American Academy of Dermatology”

The model successfully grew and differentiated hair follicle cells in the lab.

research Modulation of the differentiated phenotype of keratinocytes of the hair follicle and from epidermis

41 citations , July 1994 in “Journal of Dermatological Science”

Hair follicle cells need complex interactions to fully differentiate.

Casein Kinase 1 Inhibition in Keratinocytes Enhances the Migration of Melanocyte Precursors in the Hair Follicle via KitL/c-Kit Signaling Pathway

research 1339 Casein kinase 1 inhibition in keratinocytes enhances the migration of melanocyte precursors in the hair follicle via KitL/c-Kit signaling pathway

April 2023 in “Journal of Investigative Dermatology”

Blocking casein kinase 1 in skin cells can help melanocyte precursors move better, potentially helping with conditions like vitiligo or gray hair.

research Ginsenosides Rb₁ and Rd Regulate Proliferation of Mature Keratinocytes Through Induction of p63 Expression in Hair Follicles

15 citations , September 2012 in “PTR. Phytotherapy research/Phytotherapy research”

Ginsenosides Rb₁ and Rd may help prevent hair loss by promoting hair cell growth.

15-Deoxy Prostaglandin J2, The Nonenzymatic Metabolite Of Prostaglandin D2, Induces Apoptosis In Keratinocytes Of Human Hair Follicles: A Possible Explanation For Prostaglandin D2-Mediated Inhibition Of Hair Growth

research 15-deoxy prostaglandin J2, the nonenzymatic metabolite of prostaglandin D2, induces apoptosis in keratinocytes of human hair follicles: a possible explanation for prostaglandin D2-mediated inhibition of hair growth

11 citations , May 2016 in “Naunyn-Schmiedeberg's Archives of Pharmacology”

A substance called 15-deoxy prostaglandin J2 can cause hair follicle cells to die, which might explain how prostaglandin D2 can lead to hair loss.

research Fabrication and characterization of epithelial scaffolds for hair follicle regeneration

4 citations , May 2012 in “Tissue Engineering and Regenerative Medicine”

Scientists created three types of structures to help regrow hair follicles, and all showed promising results for hair regeneration.

research Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes

11 citations , March 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

A gene mutation causes early keratinocyte maturation leading to hair loss in Olmsted syndrome.

research Vesicle Formation and Follicular Root Sheath Separation in Mice Homozygous for Deleterious Alleles at the Balding (bal) Locus

38 citations , September 1997 in “The journal of investigative dermatology/Journal of investigative dermatology”

A mutation in mice causes hair loss and skin issues due to a defect in a gene affecting cell adhesion.

CD34 Glycoprotein Identifies Putative Stem Cells Located in the Isthmic Region of Canine Hair Follicles

research Epidermal and Hair Follicle Progenitor Cells Express Melanoma-Associated Chondroitin Sulfate Proteoglycan Core Protein

51 citations , February 2004 in “Journal of Investigative Dermatology”

MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.