Androgenetic alopecia, or hair loss, is caused by a mix of genetics, hormones, and environment, where testosterone affects hair growth and causes hair to become smaller and grow for a shorter time.
January 2020 in “Archives of Medicine and Health Sciences” Certain immune molecules and stress affect hair loss, and while genes play a role, more research is needed to fully understand and treat it.
January 2002 in “Agritrop (Cirad)” The hr gene is linked to hair loss in Valle del Belice sheep.
March 2011 in “European Urology Supplements” Gene variation affects prostate issues and hair loss.
17 citations
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April 2021 in “Frontiers in Pharmacology” Activating Nrf2 can help protect against hearing loss.
2 citations
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July 2015 in “Journal of Cosmetic Dermatology” No clear link between specific gene and hair loss in Mexican brothers.
Cross-section trichometry is an accurate method to measure hair loss and growth.
73 citations
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June 2010 in “PLoS Genetics” A gene mutation in mice causes hair loss, weak bones, and protein buildup, showing how protein processing issues can lead to diseases.
55 citations
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January 2016 in “Annals of Dermatology” Microneedle stimulation can increase hair growth in mice.
30 citations
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October 2010 in “Journal of The American Academy of Dermatology” The conclusion suggests a possible link between iron levels and hair health in women, recommending further research on iron supplementation for hair loss.
28 citations
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September 2013 in “Journal of Investigative Dermatology” The document concludes that dermal papilla cells are key for hair growth and could be used in new hair loss treatments.
27 citations
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March 2018 in “Biomaterials” Three specific proteins can turn adult skin cells into hair-growing cells, suggesting a new hair loss treatment.
23 citations
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May 2009 in “International Journal of Dermatology” AR gene not major factor in female hair loss; different from male hair loss.
14 citations
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July 2021 in “Biomolecules” Centipeda minima extract helps hair grow by activating important growth signals and could be a promising hair loss treatment.
13 citations
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April 2020 in “Experimental Cell Research” PCAT1 helps hair growth by controlling miR-329/Wnt10b.
6 citations
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June 2018 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism” Patients with the same genetic mutation for vitamin D-resistant rickets showed different symptoms but all improved with treatment except for hair loss.
5 citations
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February 2019 in “The New England Journal of Medicine” Certain mutations in the PADI3 gene may increase the risk of developing a type of scarring hair loss common in women of African descent.
5 citations
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November 2008 in “Advances in Dermatology” The review highlights the importance of stem cells in hair health and suggests new treatment strategies for hair loss conditions.
4 citations
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August 2023 in “Journal of Cosmetic Dermatology” Gynostemma pentaphyllum extract may help grow hair and prevent graying.
February 2025 in “Biomolecules” Melatonin can help or hinder hair growth depending on the dose.
October 2024 in “Scientific Reports” OXTR agonists may promote hair growth and be effective for treating hair loss.
October 2023 in “Current Issues in Molecular Biology” The YH complex, made from Astragalus membranaceus and Cinnamomum cassia, may help treat hair loss by promoting hair growth and follicle development.
April 2018 in “Journal of Investigative Dermatology” The research found that a specific skin cell type not only triggers hair growth but also controls hair color, and that aging can lead to hair loss and color changes.
January 2018 in “Refubium (Universitätsbibliothek der Freien Universität Berlin)” Chemotherapy causes temporary hair loss in women, while Tamoxifen does not significantly affect hair, and genetics show no link between female pattern hair loss and common baldness genes.
June 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Six new risk spots for early hair loss were found, which also link to Parkinson's disease and lower fertility. Two genes, FOXA2 and HDAC4, could be new treatment targets. Hair loss might also be connected to heart disease, metabolic syndrome, and prostate cancer.
3 citations
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July 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” Zebrafish regenerate sensory hair cells through three phases, offering insights for potential mammal applications.
April 2016 in “Journal of Investigative Dermatology” Sonic hedgehog signaling is needed for the development of touch-receptor cells in the skin, and the loss of Polycomb repressive complex 2 can lead to more of these cells.
20 citations
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January 2002 in “Laboratory Animals” Mutations in the hairless gene cause hair loss and skin cysts in rhesus macaques.
16 citations
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July 2021 in “American Journal of Medical Genetics Part A” Mutations in the LSS gene cause hair loss and may affect brain development, with varying severity.
7 citations
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March 2024 in “Non-coding RNA Research” DNA methylation of miR-365-1 causes hair follicle stem cell death by affecting DAP3.