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GlossaryHair Matrix Cell Proliferation

process where hair follicle cells rapidly divide for growth

Hair Matrix Cell Proliferation refers to the process by which cells in the hair matrix, located at the base of the hair follicle, rapidly divide and multiply. This cell division is crucial for hair growth, as these new cells push older cells upward, eventually forming the hair shaft that emerges from the scalp. For professionals, understanding this process is key to addressing hair growth disorders and developing treatments for conditions like alopecia.

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research Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice

173 citations , September 2011 in “Journal of Investigative Dermatology”

IL-6 contributes to hair loss by shortening the growth phase and causing hair follicles to regress.

research Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells through ERK Signaling

23 citations , February 2019 in “International Journal of Molecular Sciences”

Activin B can boost hair growth by promoting cell proliferation and cell cycle progression.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

30 citations , April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

Induction of Hair Growth in Hair Follicle Cells and Organ Cultures Upon Treatment with 30 kHz Frequency Inaudible Sound via Cell Proliferation and Antiapoptotic Effects

research Induction of hair growth in hair follicle cells and organ cultures upon treatment with 30 kHz frequency inaudible sound via cell proliferation and antiapoptotic effects

January 2022 in “Biomedical Reports”

Inaudible sound at 30 kHz can boost hair growth and decrease hair loss by promoting cell growth and reducing cell death in hair follicles.

MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations , December 2020 in “Frontiers in cell and developmental biology”

miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.

research Differences in Hair Follicle Dermal Papilla Volume are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations , December 1999 in “Journal of Investigative Dermatology”

Hair follicle size is mainly influenced by the number of cells and extracellular matrix volume, with cell number having a larger impact.

research IL-15 Prolongs Anagen, Stimulates Proliferation, and Suppresses Apoptosis in the Hair Matrix of Human Scalp Hair Follicles

9 citations , August 2023 in “Journal of Investigative Dermatology”

IL-15 helps hair grow longer and stronger by extending the growth phase and reducing cell death.

research “Miliacin encapsulated by polar lipids stimulates cell proliferation in hair bulb and improves telogen effluvium in women”

3 citations , May 2019 in “Journal of Cosmetic Dermatology”

Miliacin with polar lipids helps hair growth and improves hair loss in women.

research Exogenous IGF-1 promotes hair growth by stimulating cell proliferation and down regulating TGF-β1 in C57BL/6 mice in vivo

53 citations , March 2014 in “Growth Hormone & IGF Research”

IGF-1 injections help mice grow more hair by increasing cell growth and blocking a hair growth inhibitor.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations , August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

ERK1/2 Pathway Involvement in Enhancement of Fatty Acids from Phaeodactylum Tricornutum Extract on Hair Follicle Cell Proliferation

research ERK1/2 Pathway Is Involved in the Enhancement of Fatty Acids from Phaeodactylum tricornutum Extract (PTE) on Hair Follicle Cell Proliferation

2 citations , January 2020 in “BioMed Research International”

Phaeodactylum tricornutum extract helps hair follicle cells grow by activating the ERK1/2 pathway.

research The Krüppel-like Factor Epiprofin Is Expressed by Epithelium of Developing Teeth, Hair Follicles, and Limb Buds and Promotes Cell Proliferation

88 citations , December 2003 in “Journal of Biological Chemistry”

Epiprofin helps cells grow in developing teeth, hair, and limbs.

research 621 An apple stem cell-derived extract increases epithelial stem cells number in the hair follicle bulge

September 2019 in “Journal of Investigative Dermatology”

Apple stem cell extract may increase the number of stem cells in a part of the hair follicle.

research Immunolocalization of telomerases in human hairs identifies proliferating cells in the bulb matrix and outer root sheath

March 2024 in “Tissue and cell/Tissue & cell”

Telomerase-positive cells are mainly in the bulb matrix and outer root sheath of hair follicles.

research Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate

57 citations , March 2018 in “International Journal of Molecular Sciences”

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

research Basonuclin as a cell marker in the formation and cycling of the murine hair follicle

27 citations , October 1998 in “Differentiation”

Basonuclin helps identify and track hair follicle development and cycling in mice.

research Basonuclin as a cell marker in the formation and cycling of the murine hair follicle

January 1998 in “Differentiation”

Basonuclin is crucial for hair follicle development and cycling in mice.

research Influence Of Extracellular Matrix On The Proliferation And Adhesion Properties Of Stem Cells Derived From Different Sources

1 citations , June 2017

Extracellular matrix components affect stem cell growth and adhesion differently based on their source.

Role of the Soluble Epoxide Hydrolase in Hair Follicle Stem Cell Homeostasis and Hair Growth

research Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth

June 2022 in “Pflügers Archiv - European Journal of Physiology”

The enzyme sEH is important for hair growth and its inhibition could help treat hair loss.

research Proliferation and differentiation of organoid hair follicle cells co-cultured with fat cells in collagen gel matrix culture

30 citations , July 1998 in “British Journal of Dermatology”

Fat cells slow hair cell growth but speed up their development.

research β-Catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an in vitro organ culture model

14 citations , July 2017 in “Fitoterapia”

Oleanolic acid promotes hair growth by increasing cell proliferation through the Wnt/β-catenin pathway.

research The effects of extra cellular matrix and growth factors on dermal papilla cell proliferation

August 1994 in “Journal of dermatological science”

Different substances affect hair and skin cell growth in various ways.

research 503 A new chemosensory control of human hair growth: Olfactory receptor OR10J1 stimulation promotes scalp hair follicle growth and progenitor cell generation ex vivo

November 2024 in “Journal of Investigative Dermatology”

Stimulating OR10J1 can promote hair growth and may help treat hair loss.

research Sustained release of dermal papilla-derived extracellular vesicles from injectable microgel promotes hair growth

46 citations , January 2020 in “Theranostics”

Injecting a special gel with human protein particles can help hair grow.

research Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture

38 citations , March 1997 in “Journal of interferon & cytokine research”

IL-1β inhibits human hair follicle growth.

Vitamins and Their Derivatives Synergistically Promote Hair Shaft Elongation via PlGF/VEGFR-1 Signalling Activation

research Vitamins and their derivatives synergistically promote hair shaft elongation ex vivo via PlGF/VEGFR-1 signalling activation

1 citations , September 2022 in “Journal of dermatological science”

Certain vitamins and their derivatives can help hair grow longer by activating specific growth signals.

research Effects of oleanolic acid on hair growth in mouse dorsal skin mediated via regulation of inflammatory cytokines

March 2023 in “Journal of Applied Biomedicine”

Oleanolic acid improved hair growth in mice by affecting hair growth pathways and reducing inflammation.

research 675 Hair loss in hephaestin knockout mice is associated with iron deficiency

April 2016 in “Journal of Investigative Dermatology”

Iron deficiency causes hair loss by affecting hair differentiation and cycling.

Interest of Silybum Marianum Extract, Manganese PCA, and Lespedeza Capitata Extract in a New Anti-Hair Loss Serum to Stimulate Hair Growth and Prolong Anagen Phase

research 586 Interest of Silybum marianum extract, Manganese PCA and Lespedeza capitata extract in a new anti-hair loss serum to stimulate hair growth and prolong anagen phase

November 2022 in “Journal of Investigative Dermatology”

The extract of Silybum marianum, Manganese PCA, and Lespedeza capitata can boost hair growth and extend the growth phase when combined in a serum.

research 004 Cell-based therapy may be effective in alopecia areata: Preclinical evidence that autologous, peripheral regulatory γdT cells are preventive in human ex vivo and therapeutic in human in vivo models

November 2022 in “Journal of Investigative Dermatology”

Cell-based therapy using specific immune cells may help treat alopecia areata by promoting hair regrowth.