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GlossaryHair Matrix Cells

specialized cells that produce and support hair growth

Hair matrix cells are specialized cells located at the base of the hair follicle. They are responsible for producing the hair shaft and the inner root sheath, which support and protect the growing hair. These cells rapidly divide and differentiate, contributing to hair growth and regeneration.

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research Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells

61 citations , October 1996 in “Development”

Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.

research Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells through ERK Signaling

23 citations , February 2019 in “International Journal of Molecular Sciences”

Activin B can boost hair growth by promoting cell proliferation and cell cycle progression.

research HAIR MATRIX CELL KINETICS: A SELECTIVE REVIEW

20 citations , September 1978 in “International Journal of Dermatology”

Hair growth is influenced by factors like genetics and nutrition, and more research is needed to understand hair loss and growth mechanisms.

MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations , December 2020 in “Frontiers in cell and developmental biology”

miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.

research β-Catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an in vitro organ culture model

14 citations , July 2017 in “Fitoterapia”

Oleanolic acid promotes hair growth by increasing cell proliferation through the Wnt/β-catenin pathway.

research Phenotypic modulation of human hair matrix cells (trichocytes) by environmental influence in vitro and in vivo.

11 citations , April 1993 in “PubMed”

Human hair cells can change based on their environment, especially interactions with certain skin cells.

research Cultivation of Hair Matrix Cells from Cashmere Goat Skins and Exemplified Applications

3 citations , August 2020 in “Animals”

Researchers found a way to grow cashmere goat hair cells in a lab and discovered that certain conditions improve these cells' growth and characteristics.

research 613 Assessment of the induction and morphogenic potential of human hair matrix cells and dermal papilla fibroblasts ex vivo

1 citations , September 2019 in “Journal of Investigative Dermatology”

Human hair matrix cells and dermal papilla fibroblasts can form early hair follicle structures but don't produce hair shafts yet.

research Acquired curved hair is caused by fusion of multiple hair matrix cells

February 2024 in “Journal of Dermatological Science”

Curved hair can develop when hair cells merge abnormally during growth.

Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats

research Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats

June 2023 in “Cells”

The research identified key molecules that help hair matrix and dermal papilla cells communicate and influence hair growth in cashmere goats.

research Comparative Analysis of mRNA and miRNA Expression between Dermal Papilla Cells and Hair Matrix Cells of Hair Follicles in Yak

December 2022 in “Cells”

Different genes and pathways are active in yak skin and hair cells, affecting hair growth and immune responses.

research Use of extracellular matrix hydrogel from human placenta to restore hair-inductive potential of dermal papilla cells

31 citations , August 2019 in “Regenerative Medicine”

Human placenta hydrogel helps restore cells needed for hair growth.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

30 citations , April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research 085 Dermal papilla cells control hair follicle matrix keratinocytes proliferation through versican

July 2024 in “Journal of Investigative Dermatology”

Versican in dermal papilla cells is crucial for healthy hair growth.

Intraoperative Bioprinting of Human Adipose-Derived Stem Cells and Extracellular Matrix Induces Hair Follicle-Like Downgrowths and Adipose Tissue Formation During Full-Thickness Craniomaxillofacial Skin Reconstruction

research Intraoperative Bioprinting of Human Adipose-derived Stem cells and Extra-cellular Matrix Induces Hair Follicle-Like Downgrowths and Adipose Tissue Formation during Full-thickness Craniomaxillofacial Skin Reconstruction

1 citations , October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Printing human stem cells and a special matrix during surgery can help grow new skin and hair-like structures in rats.

research Enhancement of hair growth through stimulation of hair follicle stem cells by prostaglandin E2 collagen matrix

1 citations , November 2022 in “Experimental cell research”

Prostaglandin E2 collagen matrix may help stimulate hair growth.

research Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells

31 citations , December 1991 in “Annals of the New York Academy of Sciences”

ORS and hair matrix cells balance growth and differentiation better than normal keratinocytes, with human dermal fibroblasts crucial for proper differentiation.

Basement Membrane Matrix Promotes the Efficiency of Hair Follicle Reconstruction In Vivo and Is a Cell Delivery Vehicle for Follicle Regeneration

research Basement Membrane Matrix Promotes the Efficiency of Hair Follicle Reconstruction In Vivo and Is a Cell Delivery Vehicle for Follicle Regeneration

1 citations , February 2017 in “Dermatologic Surgery”

The basement membrane matrix helps rebuild hair follicles faster and more effectively.

research Proliferation and differentiation of organoid hair follicle cells co-cultured with fat cells in collagen gel matrix culture

30 citations , July 1998 in “British Journal of Dermatology”

Fat cells slow hair cell growth but speed up their development.

research Porcine acellular dermal matrix facilitates hair follicle stem cells entering the hair cycle in C57/BL6 mice

January 2026 in “Materialia”

Porcine ADM scaffold helps hair growth in mice.

Concentrated Nanofat: A Modified Fat Extraction Promotes Hair Growth in Mice via Stem Cells and Extracellular Matrix Components Interaction

research Concentrated nanofat: a modified fat extraction promotes hair growth in mice via the stem cells and extracellular matrix components interaction

4 citations , September 2020 in “Annals of Translational Medicine”

Concentrated nanofat helps mice grow hair by activating skin cells and may be used to treat hair loss.

research Stem cell factor combined with matrix proteins promotes attachment and migration of amelanotic melanocyte from human follicle hair

January 2006 in “Linchuang pifuke zazhi”

Stem cell factor and certain proteins help melanocytes from hair follicles move and attach better, aiding vitiligo repigmentation.

research Organotypic Cocultures as Models to Study Cell-Cell and Cell-Matrix Interactions of Human Hair Follicle Cells

18 citations , January 1994 in “Skin Pharmacology and Physiology”

Human dermal fibroblasts and hair papilla cells help outer root sheath cells grow and develop properly.

research Effect of porcine acellular dermal matrix on the expression of stromal cell-derived factor-1 and Wnt3a/β-catenin signaling pathway in mice hair follicle regeneration

February 2019 in “Chin J Injury Repair and Wound Healing(Electronic Edition)”

Porcine acellular dermal matrix helps hair growth by boosting specific proteins and signals.

research 840 Early and late matrix progenitors form the terminally differentiated cell layers of the hair follicle

April 2017 in “Journal of Investigative Dermatology”

Early and late matrix progenitors in hair follicles create different cell layers, with early ones forming the companion layer and later ones forming the inner root sheath and hair shaft.

research Tracing Recombinant Bovine Somatotropin Ab(Use) Through Gene Expression in Blood, Hair Follicles, and Milk Somatic Cells: A Matrix Comparison

4 citations , July 2018 in “Molecules”

Gene expression in milk cells and blood can help detect illegal rbST use in cows.

research Immortalized Rat Whisker Dermal Papilla Cells Cooperate with Mouse Immature Hair Follicle Buds to Activate Type IV Procollagenases in Collagen Matrix Coculture: Correlation with Ability to Promote Hair Follicle Development in Nude Mouse Grafts

11 citations , August 1995 in “Journal of Investigative Dermatology”

research In Vitro Differences Between Keratinocyte Stem Cells and Transit-Amplifying Cells of the Human Hair Follicle

52 citations , October 2005 in “Journal of Investigative Dermatology”

Hair follicle stem cells have greater longevity and adhesion, while transit-amplifying cells are more mobile.

research Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture

38 citations , March 1997 in “Journal of interferon & cytokine research”

IL-1β inhibits human hair follicle growth.

research Co‐culture of Human Hair Follicles and Dermal Papillae in a Collagen Matrix

36 citations , November 1990 in “The Journal of Dermatology”

Dermal papillae enhance hair follicle growth and structure.