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GlossaryHair Matrix

region where hair cells rapidly divide and grow

The hair matrix is a region at the base of the hair follicle where cells rapidly divide and produce the hair shaft. These cells are responsible for the growth and formation of hair, and their activity is influenced by various factors including genetics and hormones.

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Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations , August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells

61 citations , October 1996 in “Development”

Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.

research A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type

60 citations , March 2006 in “Journal of Medical Genetics”

A mutation in the KRTHB5 gene causes hair and nail issues.

research Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles

60 citations , December 2003 in “Journal of Investigative Dermatology”

K6hf is found in specific parts of hair follicles, nails, and tongue, and is linked to hair growth and structure.

research Distribution of Extracellular Matrix Molecules in Human Hair Follicles

45 citations , December 1991 in “Annals of the New York Academy of Sciences”

ECM molecules are crucial for hair growth and development.

research Co‐culture of Human Hair Follicles and Dermal Papillae in a Collagen Matrix

36 citations , November 1990 in “The Journal of Dermatology”

Dermal papillae enhance hair follicle growth and structure.

Exogenous Stimulation with Eclipta Alba Promotes Hair Matrix Keratinocyte Proliferation and Downregulates TGF-β1 Expression in Nude Mice

research Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice

24 citations , December 2014 in “International Journal of Molecular Medicine”

Eclipta alba extract helps increase hair growth and decrease hair loss-related protein in mice.

research Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells through ERK Signaling

23 citations , February 2019 in “International Journal of Molecular Sciences”

Activin B can boost hair growth by promoting cell proliferation and cell cycle progression.

research ILK modulates epithelial polarity and matrix formation in hair follicles

22 citations , December 2013 in “Molecular biology of the cell”

ILK is essential for proper hair follicle development and structure.

research HAIR MATRIX CELL KINETICS: A SELECTIVE REVIEW

20 citations , September 1978 in “International Journal of Dermatology”

Hair growth is influenced by factors like genetics and nutrition, and more research is needed to understand hair loss and growth mechanisms.

research Pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge

18 citations , March 2009 in “Experimental Dermatology”

Pilomatricoma can develop into various hair-related structures.

MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations , December 2020 in “Frontiers in cell and developmental biology”

miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.

research Study on dissolution mechanism of cortisol and cortisone from hair matrix with liquid chromatography–tandem mass spectrometry

16 citations , March 2013 in “Clinica Chimica Acta”

Cortisol and cortisone release from hair increases in steps over time during incubation.

research β-Catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an in vitro organ culture model

14 citations , July 2017 in “Fitoterapia”

Oleanolic acid promotes hair growth by increasing cell proliferation through the Wnt/β-catenin pathway.

research Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix

12 citations , May 2014 in “International Journal of Molecular Medicine”

Chrysanthemum zawadskii extract helps hair grow by stimulating hair cells.

research Phenotypic modulation of human hair matrix cells (trichocytes) by environmental influence in vitro and in vivo.

11 citations , April 1993 in “PubMed”

Human hair cells can change based on their environment, especially interactions with certain skin cells.

research Two-dimensional electrophoretic analysis of human hair keratins, especially hair matrix proteins

10 citations , January 1989 in “Archives of Dermatological Research”

The method effectively analyzes human hair proteins, especially nonfilamentous ones.

research IL-15 Prolongs Anagen, Stimulates Proliferation, and Suppresses Apoptosis in the Hair Matrix of Human Scalp Hair Follicles

9 citations , August 2023 in “Journal of Investigative Dermatology”

IL-15 helps hair grow longer and stronger by extending the growth phase and reducing cell death.

research Cultivation of Hair Matrix Cells from Cashmere Goat Skins and Exemplified Applications

3 citations , August 2020 in “Animals”

Researchers found a way to grow cashmere goat hair cells in a lab and discovered that certain conditions improve these cells' growth and characteristics.

research 613 Assessment of the induction and morphogenic potential of human hair matrix cells and dermal papilla fibroblasts ex vivo

1 citations , September 2019 in “Journal of Investigative Dermatology”

Human hair matrix cells and dermal papilla fibroblasts can form early hair follicle structures but don't produce hair shafts yet.

research The Potential of Hair Matrix for Biomarker Analysis in Schizophrenia

September 2025 in “International Journal of Molecular Sciences”

Hair analysis could help diagnose and treat schizophrenia more effectively.

research Acquired curved hair is caused by fusion of multiple hair matrix cells

February 2024 in “Journal of Dermatological Science”

Curved hair can develop when hair cells merge abnormally during growth.

research Hair analysis: Assessment of homemade hair treatment effects on drug concentrations in the keratin matrix

July 2023 in “Drug testing and analysis (Print)”

Homemade hair treatments can significantly lower drug levels in hair, possibly causing false-negative drug tests.

Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats

research Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats

June 2023 in “Cells”

The research identified key molecules that help hair matrix and dermal papilla cells communicate and influence hair growth in cashmere goats.

research Comparative Analysis of mRNA and miRNA Expression between Dermal Papilla Cells and Hair Matrix Cells of Hair Follicles in Yak

December 2022 in “Cells”

Different genes and pathways are active in yak skin and hair cells, affecting hair growth and immune responses.

DNA Dioxygenases Tet1/2/3 Control Hair Matrix Keratinocyte Differentiation and Hair Shaft Shape via Regulation of Hair Keratin Gene Expression

research 764 DNA dioxygenases Tet1/2/3 control hair matrix keratinocyte differentiation and hair shaft shape via regulation of hair keratin gene expression

June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzymes Tet1, Tet2, and Tet3 are important for the development of hair follicles and determining hair shape by controlling hair keratin genes.

research Hair Matrix Cyst

May 2020 in “International journal of dermatology and venereology”

Hair matrix cysts are rare skin nodules with unique features, often needing surgical removal.

research Use of extracellular matrix hydrogel from human placenta to restore hair-inductive potential of dermal papilla cells

31 citations , August 2019 in “Regenerative Medicine”

Human placenta hydrogel helps restore cells needed for hair growth.

research Expression of extracellular matrix in hair follicle mesenchyme in alopecia areata

11 citations , December 1990 in “British Journal of Dermatology”

Alopecia areata may involve disrupted mesenchymal function in hair follicles.

Intraoperative Bioprinting of Human Adipose-Derived Stem Cells and Extracellular Matrix Induces Hair Follicle-Like Downgrowths and Adipose Tissue Formation During Full-Thickness Craniomaxillofacial Skin Reconstruction

research Intraoperative Bioprinting of Human Adipose-derived Stem cells and Extra-cellular Matrix Induces Hair Follicle-Like Downgrowths and Adipose Tissue Formation during Full-thickness Craniomaxillofacial Skin Reconstruction

1 citations , October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Printing human stem cells and a special matrix during surgery can help grow new skin and hair-like structures in rats.