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GlossaryVascularization

process of forming new blood vessels in tissue

Vascularization refers to the process by which new blood vessels form within a tissue. This is crucial for delivering oxygen and nutrients to tissues, promoting healing, and supporting the growth of new cells. In the context of hair and alopecia, proper vascularization of the scalp is essential for healthy hair growth, as it ensures that hair follicles receive the necessary nutrients and oxygen.

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The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization, and Hair Growth in a Porcine Model

research The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model

16 citations , April 2016 in “PLoS ONE”

Negative pressure treatment improved skin thickness, blood vessel growth, and hair growth.

Poor Perifollicular Vascularization Is Associated With Nutrient Insufficiency and a Quiescent Metabolic Phenotype in Intermediate Hair Follicles From Patients With Female Pattern Hair Loss

research 333 Poor perifollicular vascularization is associated with nutrient insufficiency and a quiescent metabolic phenotype in intermediate hair follicles from patients with female pattern hair loss

October 2021 in “Journal of Investigative Dermatology”

Poor blood supply in hair follicles is linked to nutrient deficiency in patients with female pattern hair loss, and adding more nutrients could potentially fix this.

research 3D multicellular micropatterning biomaterials for hair regeneration and vascularization

3 citations , January 2023 in “Materials horizons”

The new biomaterial helps grow blood vessels and hair for skin repair.

research Vascularization of skin substitute constructed by vascular endothelial growth factor 165 gene-modified hair follicle stem cells compounded with three-dimensional gelatin-chondroitin sulfate-hyaluronic acid

June 2014

The modified stem cells with VEGF165 in a special scaffold improved blood vessel growth and wound healing for skin repair.

research ESDR333 – Poor perifollicular vascularization is associated with nutrient insufficiency and a quiescent metabolic phenotype in intermediate hair follicles from patients with female pattern hair loss

September 2021

research Control of hair growth and follicle size by VEGF-mediated angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Inhibitory effects of bFGF, VEGF and minoxidil on collagen synthesis by cultured hair dermal papilla cells

23 citations , July 1996 in “Archives of Dermatological Research”

bFGF, VEGF, and minoxidil decrease collagen production in hair cells, possibly affecting hair growth.

Perifollicular Vascularization: Cocultures and Tricultures Approaches to Study the Cross-Talk Between Microvascular Endothelial Cells, Follicle Papilla Cells, and Keratinocytes

research Perifollicular vascularization: Cocultures and tricultures approaches to study the cross-talk between microvascular endothelial cells, follicle papilla cells and keratinocytes

December 2015 in “Vascular Pharmacology”

Hair papilla cells are crucial for blood vessel development in hair follicles, affecting hair growth and loss.

research Hair Follicle–Derived Blood Vessels Vascularize Tumors in Skin and Are Inhibited by Doxorubicin

76 citations , March 2005 in “Cancer Research”

Doxorubicin can block blood vessels from hair follicles, reducing skin tumor growth.

research Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase

52 citations , January 2003 in “Journal of Investigative Dermatology”

Thrombospondin-1 is crucial for hair follicle regression and reduced blood vessel growth during the catagen phase.

research Preferential Crosstalk between Perifollicular Capillary Vessels and Dermal Papilla Cells during Hair Cycling Homeostasis

October 2025 in “Research Square (Research Square)”

Enhancing blood vessel interactions with hair cells may help treat hair loss and skin aging.

research Conditioned media-integrated microneedles for hair regeneration through perifollicular angiogenesis

12 citations , August 2022 in “Journal of Controlled Release”

A new microneedle patch effectively promotes hair growth by increasing blood vessel formation around hair follicles.

research Alterations in Hair Follicle Morphology and Hair Shaft Production After Follicular Unit Transplantation

8 citations , February 2016 in “The American Journal of Dermatopathology”

Hair transplants can make hair follicles larger and hair shafts thicker.

research Angiopoietin-1 induces survival and proliferation of hair follicle dermal papilla cells through integrin α5β1 signaling

September 2025 in “Frontiers in Medicine”

Angiopoietin-1 helps hair cells survive and grow, making it a potential treatment for hair loss.

research Data Sheet 1_Angiopoietin-1 induces survival and proliferation of hair follicle dermal papilla cells through integrin α5β1 signaling.pdf

September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Angiopoietin-1 helps hair follicle cells survive and grow, potentially treating hair loss.

research The effect and mechanism of Yangxue Shengfa Capsules on hair growth in mice

January 2010 in “Xiandai yaowu yu linchuang”

Yangxue Shengfa Capsules promote hair growth by increasing blood flow and hair follicles.

research Scalp vascularization as a marker of topical minoxidil treatment efficacy in patients with androgenetic alopecia

March 2021 in “Postepy Dermatologii I Alergologii”

Minoxidil works equally well for hair growth regardless of scalp blood flow.

research Paracrine crosstalk between human hair follicle dermal papilla cells and microvascular endothelial cells

35 citations , February 2015 in “Experimental Dermatology”

Cells from the base of hair follicles help blood vessel cells survive and grow, which is important for healthy hair.

research Vascular endothelial cells: Targets for studying the activity of hair follicle cell-produced VEGF

9 citations , December 1996 in “Cell Biology and Toxicology”

Hair follicle cells produce VEGF, which can promote blood vessel cell growth and movement.

Effects of the Biomimetic Peptide Sh-Polypeptide 9 (CG-VEGF) on Cocultures of Human Hair Follicle Dermal Papilla Cells and Microvascular Endothelial Cells

research Effects of the biomimetic peptide Sh-Polypeptide 9 (CG-VEGF) on cocultures of human hair follicle dermal papilla cells and microvascular endothelial cells

7 citations , December 2015 in “Experimental Dermatology”

Sh-Polypeptide 9 may be better than minoxidil for hair growth and protection against damage.

research Tissue engineering of human hair follicles using a biomimetic developmental approach

184 citations , December 2018 in “Nature Communications”

Researchers created human hair follicles using a new method that could help treat hair loss.

research Peppermint Oil Promotes Hair Growth without Toxic Signs

30 citations , December 2014 in “Toxicological Research”

Peppermint oil can effectively promote hair growth without being toxic.

research From Hair to Cornea: Toward the Therapeutic Use of Hair Follicle-Derived Stem Cells in the Treatment of Limbal Stem Cell Deficiency

135 citations , October 2010 in “Stem Cells”

Hair follicle stem cells can help treat eye surface issues by becoming corneal cells.

research Transcriptome Sequencing Reveals Differences between Primary and Secondary Hair Follicle-derived Dermal Papilla Cells of the Cashmere Goat (Capra hircus)

81 citations , September 2013 in “PLoS ONE”

Primary and secondary hair follicle cells in Cashmere goats have different gene expressions affecting hair growth and size.

Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

research Impact of the Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma (A-PRP) and Activated Platelet-Rich Plasma (AA-PRP) in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

58 citations , January 2020 in “International Journal of Molecular Sciences”

Different methods of preparing Platelet-Rich Plasma (PRP) can affect wound healing and hair regrowth in plastic surgery. Using a kit with specific standards helps isolate PRP that meets quality criteria. Non-Activated PRP and Activated PRP have varying effects depending on the tissue and condition treated. For hair regrowth, Non-Activated PRP increased hair density more than Activated PRP. Both treatments improved various aspects of scalp health.

Angiogenin Is Expressed in Human Dermal Papilla Cells and Stimulates Hair Growth

research Mechanisms and clinical progress of adipose-derived stem cells and their derivatives in the treatment of hair loss

3 citations , August 2025 in “Stem Cell Research & Therapy”

Adipose-derived stem cells show promise in treating hair loss by promoting hair regrowth and improving hair follicle function.