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Did you mean Hair Follicle Mesenchymal Stem Cells?

GlossaryHair Follicle Mesenchymal Stem Cells

cells in hair follicles that can become various tissue types

Hair Follicle Mesenchymal Stem Cells (HF-MSCs) are a type of stem cell found within the hair follicle that have the ability to differentiate into various cell types, including those that form skin, hair, and connective tissues. These cells play a crucial role in hair growth, wound healing, and tissue regeneration, making them a significant focus in regenerative medicine and treatments for conditions like alopecia.

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Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis

26 citations , August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

research Engineered Hair Follicle Mesenchymal Stem Cells Overexpressing Controlled-Release Insulin Reverse Hyperglycemia in Mice with Type l Diabetes

17 citations , May 2014 in “Cell transplantation”

Genetically modified stem cells from human hair follicles can lower blood sugar and increase survival in diabetic mice.

research A Potential Differentiation of Adipose and Hair Follicle-derived Mesenchymal Stem Cells to Generate Neurons Induced with EGF, FGF, PDGF and Forskolin

14 citations , January 2020 in “Research Journal of Pharmacy and Technology”

Fat and hair follicle stem cells can become neurons, useful for treating brain diseases.

research Hair follicle mesenchymal stem cell exosomal lncRNA H19 inhibited NLRP3 pyroptosis to promote diabetic mouse skin wound healing

13 citations , February 2023 in “Aging”

A substance from hair follicle stem cells helps heal skin wounds in diabetic mice by promoting cell growth and preventing cell death.

research The Angiogenic Potential of Mesenchymal Stem Cells from the Hair Follicle Outer Root Sheath

8 citations , February 2021 in “Journal of Clinical Medicine”

Hair follicle stem cells are promising for blood vessel formation and tissue repair.

research The homing of exogenous hair follicle mesenchymal stem cells into hair follicle niches

6 citations , November 2023 in “JCI Insight”

Exogenous stem cells can effectively integrate into hair follicles, promoting hair growth.

research Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischemia–reperfusion injury via intrinsic and paracrine mechanisms in a rat model

6 citations , October 2022 in “Frontiers in Cell and Developmental Biology”

Transplanted hair follicle stem cells can heal damaged rat intestines.

research The Potential of a Hair Follicle Mesenchymal Stem Cell-Conditioned Medium for Wound Healing and Hair Follicle Regeneration

6 citations , April 2020 in “Applied sciences”

Hair growth medium helps heal wounds and regrow hair in mice.

research The role and mechanism of engineered nanovesicles derived from hair follicle mesenchymal stem cells in the treatment of UVB‐induced skin photoaging

5 citations , May 2024 in “Journal of Cosmetic Dermatology”

Engineered nanovesicles from hair follicle stem cells can effectively treat UVB-induced skin aging.

research From hair to liver: emerging application of hair follicle mesenchymal stem cell transplantation reverses liver cirrhosis by blocking the TGF-β/Smad signaling pathway to inhibit pathological HSC activation

4 citations , February 2022 in “PeerJ”

Hair follicle stem cell transplants can reverse liver cirrhosis by blocking harmful cell activation.

Transplanted Hair Follicle Mesenchymal Stem Cells Alleviated Small Intestinal Ischemia–Reperfusion Injury via Intrinsic and Paracrine Mechanisms in a Rat Model

research Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischaemia–reperfusion injury via intrinsic and paracrine mechanisms in a rat model

June 2022 in “Research Square (Research Square)”

Hair follicle stem cells can help heal intestinal injuries in rats.

Ficoll Density Gradient Sedimentation Isolation of Pelage Hair Follicle Mesenchymal Stem Cells from Adult Mouse Back Skin: A Novel Method for Hair Follicle Mesenchymal Stem Cells Isolation

research Ficoll density gradient sedimentation isolation of pelage hair follicle mesenchymal stem cells from adult mouse back skin: A novel methods for hair follicle mesenchymal stem cells isolation.

March 2022 in “Research Square (Research Square)”

The new method isolates more hair follicle stem cells from mice quickly and these cells help promote hair growth.

research Comparative Characterization of Hair Follicle Dermal Stem Cells and Bone Marrow Mesenchymal Stem Cells

151 citations , February 2006 in “Stem Cells and Development”

Hair follicles can be a good source of stem cells like those from bone marrow.

A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice

research A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice

36 citations , January 2017 in “Stem Cells International”

A special stem cell fluid can speed up wound healing and hair growth in mice.

research Effects of mesenchymal stem cell therapy on alopecia areata in cellular and hair follicle organ culture models

16 citations , October 2018 in “Experimental Dermatology”

Mesenchymal stem cell therapy may help treat alopecia areata by promoting hair growth and reducing inflammation.

research Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles

14 citations , April 2021 in “International journal of molecular sciences”

Mesenchymal stem cells may help treat hair loss by improving hair cell growth and reducing inflammation.

research OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases

57 citations , January 2019 in “Stem Cell Research & Therapy”

OCT4 helps hair stem cells renew and fight aging, potentially aiding hair regrowth.

research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

research Proteins from Stressed Mesenchymal Stem Cells Can Repair Hair Follicles and Promote Hair Regeneration

May 2025 in “ACS Pharmacology & Translational Science”

Proteins from stressed stem cells can help regrow hair.

research Mesenchymal stem cell exosomes enhance the development of hair follicle to ameliorate androgenetic alopecia

March 2025 in “World Journal of Stem Cells”

Stem cell exosomes may help treat hair loss by promoting hair growth.

Clonal Multipotency and Effect of Long-Term In Vitro Expansion on Differentiation Potential of Human Hair Follicle Derived Mesenchymal Stem Cells

research Clonal multipotency and effect of long-term in vitro expansion on differentiation potential of human hair follicle derived mesenchymal stem cells

73 citations , August 2011 in “Stem Cell Research”

Human hair follicle stem cells can turn into multiple cell types but lose some of this ability after being grown in the lab for a long time.

research Hair follicle-derived mesenchymal cells support undifferentiated growth of embryonic stem cells

7 citations , March 2017 in “Experimental and Therapeutic Medicine”

Hair follicle cells can help keep embryonic stem cells undifferentiated.

research Fully functional hair follicle organ regeneration using organ-inductive potential stem cells with an accessory mesenchymal cell population in an in vitro culture system

February 2026 in “Biochemical and Biophysical Research Communications”

Scientists successfully regenerated functional hair follicles using specific stem cells and mesenchymal cells.

Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells

research Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells

42 citations , February 2017 in “Scientific Reports”

Researchers found a way to create cells from stem cells that act like human cells important for hair growth and could be used for hair regeneration treatments.

research Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species

15 citations , September 2009 in “European Journal of Histochemistry”

CD90 is abundantly present on stem-like cells in dog hair follicles.

Application of Extracellular Vesicles From Mesenchymal Stem Cells Promotes Hair Growth by Regulating Human Dermal Cells and Follicles

research Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles

6 citations , July 2022 in “World journal of stem cells”

Using extracellular vesicles from stem cells can help hair grow by affecting scalp cells and hair follicles.

research Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species

6 citations , September 2009 in “European journal of histochemistry”

CD90 is present on specific cells in dog hair follicles.

research Bio-Pulsed Stimulation Effectively Improves the Production of Avian Mesenchymal Stem Cell-Derived Extracellular Vesicles That Enhance the Bioactivity of Skin Fibroblasts and Hair Follicle Cells

3 citations , November 2022 in “International journal of molecular sciences”

Bio-pulsed stimulation increases production of beneficial vesicles from bird stem cells that improve skin and hair cell functions.

research Mesenchymal Stem Cells from Mouse Hair Follicles Inhibit the Development of Type 1 Diabetes

May 2024 in “International Journal of Molecular Sciences”

Mouse hair follicle stem cells can help prevent Type 1 Diabetes.