24 citations
,
January 2020 in “JAAD Case Reports” Topical metformin helped regrow hair in two women with a hard-to-treat scarring hair loss condition.
16 citations
,
March 1981 in “PubMed” Minoxidil significantly lowers blood pressure in patients with hard-to-treat hypertension, but can cause fluid retention and excessive hair growth.
15 citations
,
November 1998 in “Australasian Journal of Dermatology” Cicatricial pemphigoid rarely affects the scalp but is hard to treat when it does.
14 citations
,
January 2014 in “Journal of Cutaneous and Aesthetic Surgery” Scalp Roller therapy helped improve hair growth in patients with hard-to-treat alopecia areata.
12 citations
,
January 2013 in “Indian Journal of Dermatology” Monilethrix is a rare genetic hair disorder that's hard to treat.
8 citations
,
November 1990 in “Archives of Dermatology” A woman with EMS showed unusual skin mucinosis without the typical hard skin syndrome, suggesting EMS can cause skin mucinosis.
6 citations
,
June 2016 in “Experimental Dermatology” Frontal Fibrosing Alopecia is a poorly understood condition that is hard to treat and causes distressing hair loss.
2 citations
,
October 2018 in “Skin appendage disorders” A boy's hair that was frizzy and hard to comb returned to normal after 9 months, possibly due to genetic factors.
2 citations
,
April 2015 in “Dermatology practical & conceptual” Daily use of antifungal shampoo can hide symptoms and make it hard to diagnose fungal scalp infections.
2 citations
,
May 2000 in “International Society of Hair Restoration Surgery” Scarring alopecias are a complex type of hair loss that are hard to treat and often can't be fixed with hair transplants.
2 citations
,
October 1985 in “Pediatrics in review” Scalp diseases change with age and can be hard to tell apart from hair disorders.
1 citations
,
July 2021 in “Journal of Skin and Sexually Transmitted Diseases” Lipedema is a painful fat disorder in women that's hard to treat, often worsens with hormonal changes, and requires symptom-focused therapies.
1 citations
,
April 1990 in “PubMed” Alopecia areata causes unpredictable hair loss and is hard to treat.
May 2025 in “Journal of Clinical Images and Medical Case Reports” Hair transplants can trigger a rare scarring hair loss that is hard to treat.
January 2024 in “Wiadomości Lekarskie” CAR-T therapy offers hope for children with hard-to-treat blood cancers.
April 2023 in “IP Indian journal of clinical and experimental dermatology” Lichen planus is a chronic autoimmune disease that is hard to treat and more common in women.
January 2023 in “Pharma innovation” Polycystic ovary syndrome affects health and can be hard to diagnose, with treatments ranging from drugs to herbal remedies.
June 2020 in “Journal of Investigative Dermatology” Getting insurance to cover the hair loss treatment tofacitinib is hard because it's not officially approved for that use.
June 2020 in “Italian journal of gynaecology & obstetrics” The document concludes that PCOS in teenagers is hard to diagnose, influenced by various factors, and should be managed with lifestyle changes and medication.
May 2014 in “Nursing Made Incredibly Easy!” Pancreatic cancer had a very low survival rate and was hard to treat effectively.
February 2013 in “Pediatrics in Review” The girl's symptoms suggest a complex condition that's hard to diagnose despite normal test results.
143 citations
,
June 1983 in “Archives of dermatology” Mental and social factors greatly affect skin conditions and doctors find it hard to deal with these aspects.
31 citations
,
April 2005 in “CRC Press eBooks” The document explains that Polycystic Ovary Syndrome is a complex condition that is hard to diagnose and manage, but it doesn't talk about hair loss or hair growth.
5 citations
,
January 2022 in “Scientific reports” The research identified two types of keratinocytes in chicken scales: one for hard scales and another for soft skin, with similarities to human skin differentiation.
November 2025 in “International Journal of Research in Medical Sciences” Unani medicine may help treat a rare, hard-to-treat hair loss pattern in children.
April 2023 in “IntechOpen eBooks” Neuropathic pruritus is a commonly overlooked and wrongly diagnosed type of chronic itching that is hard to treat.
December 2021 in “International Journal of Research in Dermatology” The study concluded that female pattern hair loss is linked to psychological distress and is hard to diagnose and treat, with its causes still not fully understood.
May 2020 in “International Journal of Dermatology and Venereology” Calcified epidermal cysts are rare, hard skin nodules that are best treated with surgical removal.
December 2014 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” Hair removal with intense pulsed light can cause rare skin lesions that are hard to fully treat.
January 2014 in “European Geriatric Medicine” A postmenopausal woman's virilization was caused by a rare ovarian tumor that was hard to detect but was successfully treated with surgery.