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research Human Trichohyalin Gene Is Clustered with the Genes for Other Epidermal Structural Proteins and Calcium-Binding Proteins at Chromosomal Locus 1q21

January 1993

The trichohyalin gene is located at chromosomal region 1q21 with other skin-related protein genes.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix

30 citations , April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research Modulation of sonic hedgehog, patched and patched-2 expression by epidermal growth factor signaling in mouse hair follicle formation

January 2000 in “Medical Entomology and Zoology”

Comparison of Ruxolitinib and a Collagen-Targeted PTH-Based Hair Cycle Stimulant on Hair Follicle Counts and Hair Growth in the C3H/HeJ Engrafted Mouse Model of Alopecia Areata

research 1108 Comparison of ruxolitinib and a collagen-targeted PTH-based hair cycle stimulant on hair follicle counts and hair growth in the C3H/HeJ engrafted mouse model of alopecia areata

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

A PTH-based treatment improved hair regrowth better than ruxolitinib in a mouse model of hair loss.

research 707 Hypoxia induced Multipotent Stem Cell-Secreted Proteins Induce Hair Growth in a Phase 1a/2b trial in Male Pattern Baldness

April 2021 in “Journal of Investigative Dermatology”

A trial showed that a new treatment is safe and effective for male pattern baldness, with most participants growing new hair.

research LB1045 Inhibition of pyruvate oxidation activates human hair follicle stem cells ex vivo

July 2024 in “Journal of Investigative Dermatology”

PP405 may help hair growth by activating hair follicle stem cells.

research Interactions of the Vitamin D Receptor with the Corepressor Hairless

42 citations , July 2007 in “Journal of Biological Chemistry”

Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.

research 518 Nutrient and stress sensing as novel physiological regulator of human hair pigmentation and greying: Role of mTORC1 activity

November 2022 in “Journal of Investigative Dermatology”

Blocking mTORC1 activity could increase hair pigmentation and potentially reverse greying.

research Comparative analysis of stemness between dermal papilla cells and human dermalstem/progenitor cells

April 2025 in “Cellular and Molecular Biology”

Human dermal stem/progenitor cells can divide and differentiate more than hair follicle dermal papilla cells.

research Trans glutaminase-mediated cross-linking in mammalian epidermis

44 citations , January 1984 in “Molecular and Cellular Biochemistry”

research The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles

September 2025 in “Science Advances”

PADI4 enzyme slows down cell growth in developing hair follicles.

research Serine-rich ultra high sulfur protein gene expression in murine hair and skin during the hair cycle.

26 citations , December 1990 in “Journal of Biological Chemistry”

Two specific genes are more active during hair growth in mice.

research Glucagon-like peptide-1 receptor and proglucagon expression in mouse skin

37 citations , March 2006 in “Regulatory Peptides”

Mice skin has components that could help with hair growth and might be used for diabetes treatment.

research Keratin 17 modulates hair follicle cycling in a TNFα-dependent fashion

169 citations , May 2006 in “Genes & Development”

Keratin 17 is crucial for normal hair growth by regulating hair cycle transitions with TNFα.

Methanol Extract of Peach Kernel Induces Human Hair Follicle Dermal Papilla Cell Proliferation via the Extracellular Signal-Regulated Kinase Signaling Pathway

research Methanol Extract of Peach Kernel Induces Human Hair Follicle Dermal Papilla Cell Proliferation via the Extracellular Signal-Regulated Kinase Signaling Pathway

January 2024 in “Indian Journal of Pharmaceutical Sciences”

Peach kernel extract may promote hair growth by boosting cell growth in hair follicles.

research iε-(γ^-Glutamyl) lysine cross-linkage in citrulline-containing protein fractions from hair

125 citations , February 1971 in “Biochemistry”

Specific cross-linkages help make hair proteins stable and strong.

research P-13 Some biomechanical properties of human hair keratin (HHK) artificial tendon

December 2000 in “日本組織細胞化学会総会プログラムおよび抄録集”

research Studies on basal cell carcinoma with emphasis on the role of the human homologue of the Drosophila patched gene

November 1997 in “Open Archive (Karolinska Institutet)”

PTCH gene mutations contribute to basal cell carcinoma development.

research Mrp3, a Mitogen-Regulated Protein/Proliferin Gene Expressed in Wound Healing and in Hair Follicles*

34 citations , May 2001 in “Endocrinology”

Mrp3 helps in wound healing and hair growth.

research VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK

120 citations , May 2012 in “Experimental Cell Research”

VEGF promotes hair follicle cell growth through the VEGFR-2/ERK pathway.

research Pre-receptor regulation of the androgen receptor

56 citations , November 2007 in “Molecular and cellular endocrinology”

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

research Three cDNA sequences of mouse type I keratins. Cellular localization of the mRNAs in normal and hyperproliferative tissues.

57 citations , January 1987 in “Journal of Biological Chemistry”

Different keratins have unique expression patterns in mouse skin cells.

research Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis

65 citations , November 2013 in “The EMBO Journal”

HDAC1 is crucial for skin development and preventing tumors.

research 061 Selective inhibition of tyrosine kinase 2 prevents and restores interleukin-12-induced hair follicle immune privilege collapse: a novel approach to alopecia areata therapy?

October 2021 in “Journal of Investigative Dermatology”

Blocking IL-12 can help treat alopecia areata by preventing hair follicle immune issues.

research Stimulation of Hair Growth by Topical Application of FK506, a Potent Immunosuppressive Agent

54 citations , February 1994 in “Journal of Investigative Dermatology”

research 700 Tyrosine kinase 2 inhibition rescues hair follicles from IL-12–mediated immune privilege collapse and reverses the induction of human alopecia areata in a humanized mouse model

July 2022 in “Journal of Investigative Dermatology”

Inhibiting TYK2 can restore hair growth in alopecia areata.

research Phosphatase Regulator NIPP1 Restrains Chemokine-Driven Skin Inflammation

7 citations , January 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

NIPP1 is important for healthy skin and could help treat skin inflammation.

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) Inhibits SCF/c-kit Signaling in 501mel Human Melanoma Cells and Abolishes Melanin Production in Mice and Brownish Guinea Pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , July 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice

January 2026 in “PLoS Biology”

ARHGEF3 is essential for proper hair follicle development in mice.

research 200 The relationship between the expression of cytokeratin 5/6 and clinicopathologic factors in invasive breast carcinoma

March 2010 in “Ejc Supplements”

CK 5/6 expression in breast cancer is linked to negative hormone receptor status and higher tumor grade.

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