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11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro

research 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

7 citations , April 2019 in “The Journal of Steroid Biochemistry and Molecular Biology”

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

research Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes

4 citations , January 1998 in “Heterocycles”

Researchers made two new compounds that could be used for medicine.

research New approach to 3-oxo-4-aza-5α-androst-1-ene-17β-(--butylcarboxamide)

14 citations , May 2005 in “Steroids”

A new method was developed to make finasteride for treating hair loss.

research New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors

14 citations , June 2011 in “Steroids”

New compounds may help treat prostate issues without affecting androgen receptors.

research Synthesis, Characterization and Evaluation of 5α, 6β-Dihalo Androsterone Derivatives as 5α-Reductase Inhibitors

May 2022 in “Current Enzyme Inhibition”

Compound 7b is a promising candidate for treating benign prostatic hyperplasia and prostate cancer.

research Synthesis and Pharmacological Evaluation of New 16-Methyl Pregnane Derivatives.

18 citations , January 2002 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.

research Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes

45 citations , August 2005 in “Bioorganic & medicinal chemistry”

New compounds with carborane showed anti-androgen effects similar to flutamide.

research 519 Design of a new molecule proven to be safe and effective for topical depigmenting and antiaging method

November 2022 in “Journal of Investigative Dermatology”

A new molecule was found to be a safe and effective skin lightener and anti-aging product.

Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides and Their Effect on 5α-Reductase Isoform 2, Androgen Receptor, and Androgen-Dependent Glands

research Synthesis of novel andostane-N-cyclohexyl-17-carboxamides, and their effect on the 5α-reductase isoform 2, the androgen receptor, and androgen-dependent glands

November 2021 in “Pharmaceutical Sciences”

New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.

Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase

research Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase

8 citations , June 1995 in “Helvetica Chimica Acta”

Compound 15a was effective in inhibiting 5α-reductase.

research Die kontrazeptive Betreuung androgenisierter Frauen mit einem niedrig dosierten cyproteronacetathaltigen Einphasenpräparat

18 citations , September 1979 in “DMW - Deutsche Medizinische Wochenschrift”

Diane is effective for treating acne, seborrhoea, androgenic alopecia, and mild hirsutism in women.

research Estudio de la reactividad de los anillos A y C de olean-12-enos naturales para la obtención de sintones quirales

January 2003 in “Dialnet (Universidad de la Rioja)”

The study found ways to create important compounds for male health from olive waste.

research Intracrinology and The Skin

82 citations , January 2000 in “Hormone Research in Paediatrics”

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

research The Antiandrogenic Action of 4–Androsten–3–one–17β– Carboxylic Acid and Its Methyl Ester on Hamster Flank Organ1

87 citations , April 1973 in “Endocrinology”

The chemicals 17βC and its methyl ester can block the effects of testosterone on hamster skin but not the effects of DHT.

research Dehydroepiandrosterone- and glucose-6-phosphate-dehydrogenases in the hair cycle of the rat

7 citations , January 1971 in “Archives of Dermatological Research”

research A Convenient Synthesis of (16S,20S)-3β-Hydroxy-5α-pregnane-20,16-carbolactam and Its N-alkyl Derivatives

2 citations , May 2020 in “Molecules”

A new, efficient method was developed to synthesize a specific compound and its derivatives.

research Breaking the “rule-of-five” to access Bridged Bicyclic Heteroaromatic Bioisosteres

3 citations , May 2025

A new method creates valuable compounds for drug discovery by breaking traditional chemical rules.

research Patent Evaluation: Δ-4,6-Steroids as Potent 5α-Reductase Inhibitors

April 1992 in “Current opinion in therapeutic patents”

New steroids were patented as effective for treating acne, hair loss, and other conditions related to hormones.

research Functional characterization and unraveling the structural determinants of novel steroid hydroxylase CYP154C7 from Streptomyces sp. PAMC26508

4 citations , October 2024 in “Heliyon”

CYP154C7 enzyme can effectively modify steroids and is promising for commercial use.

research Effect of Hataedock Treatment on Epidermal Structure Maintenance through Intervention in the Endocannabinoid System

2 citations , January 2020 in “Evidence-based Complementary and Alternative Medicine”

Hataedock treatment improved skin health and reduced atopic dermatitis symptoms by enhancing the skin barrier and reducing inflammation.

research [Anti-androgens. Their use in dermatology].

January 1981 in “PubMed”

Cyproterone acetate with ethynyl estradiol significantly improved acne and seborrhea in women, but was less effective for hair loss and excessive hair growth.

research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations , October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

research Synthesis and Pharmacological Evaluation of New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors

13 citations , January 2005 in “Chemical and Pharmaceutical Bulletin”

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

research Hyperbranched glycerol-based core-amphiphilic branched shell nanotransporters for dermal drug delivery

10 citations , May 2016 in “Polymer”

New nanocarriers improve skin drug delivery with low toxicity at certain concentrations.

research Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone

8 citations , October 2013 in “Chemistry Central Journal”

Metabolite 7 is a strong inhibitor for Alzheimer's disease management.

research Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics

December 2022 in “Scientific Reports”

Compound 4 is a promising treatment for hair loss with low toxicity.

research Is dehydroepiandrosterone a hormone?

403 citations , November 2005 in “Journal of Endocrinology”

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

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