January 1983 in “Elsevier eBooks” Masculinization in affected individuals occurs gradually after puberty due to hormone changes.
October 1984 in “Kidney international” The patient had complex urinary tract issues and ambiguous genitalia, with physical features suggesting a hormonal imbalance.
96 citations
,
September 1975 in “The Journal of Clinical Endocrinology & Metabolism” Hormone levels change during puberty, leading to physical developments like pubic hair and voice changes.
August 2021 in “Clinical and Experimental Dermatology” Children under 10 can experience hair thinning without hormone issues, and it may improve with treatment.
7 citations
,
January 1992 in “Adolescent and pediatric gynecology” Early diagnosis and treatment of PCOS in teenagers can help prevent more severe adult PCOS.
19 citations
,
December 2021 in “Endocrine Reviews” There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.
1 citations
,
November 2024 in “European Journal of Endocrinology” Higher childhood DHEAS levels are linked to advanced puberty and DNA changes.
January 2018 in “Elsevier eBooks” 5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.
16 citations
,
January 2005 in “Pediatric Dermatology” A 10-year-old girl with Fox Fordyce disease improved with treatment, suggesting the disease can occur before puberty and might be underdiagnosed in young girls.
July 2024 in “Journal of Pediatric Endocrinology and Metabolism” Ovarian hyperthecosis should be considered in young women with severe male-like symptoms and can be managed with hormone treatments.
50 citations
,
February 2007 in “Clinical obstetrics and gynecology” Early detection and treatment of PCOS in teenagers is important to manage symptoms and prevent severe issues.
28 citations
,
March 2000 in “Obstetrics and gynecology clinics of North America” Hirsutism in teen girls is common, usually harmless, but can sometimes signal serious issues and is treatable.
January 2023 in “Archives of Disease in Childhood Education & Practice” Hirsutism in teens is often due to polycystic ovarian syndrome and needs careful assessment and support.
August 2025 in “Journal of Pediatric Endocrinology and Metabolism” A rare ovarian tumor in a 2-year-old girl was successfully removed, normalizing her hormone levels.
116 citations
,
December 2013 in “The Journal of Pediatrics” Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.
83 citations
,
September 1993 in “Endocrinology and Metabolism Clinics of North America”
71 citations
,
August 2019 in “The journal of sexual medicine” Testosterone treatment effectively causes male physical development in transgender male adolescents but may lead to side effects like acne, higher BMI and blood pressure, lower good cholesterol, and decreased bone density.
20 citations
,
March 1975 in “Clinics in Endocrinology and Metabolism” October 2025 in “Environment International” Exposure to certain chemicals before birth and during childhood may affect puberty timing.
77 citations
,
September 1983 in “Acta Paediatrica” Dexamethasone effectively normalizes elevated steroid levels in girls with premature adrenarche.
January 2023 in “Pediatrics International” Non-classical 21-hydroxylase deficiency can be missed in newborn screenings and should be considered in cases of early puberty or virilization.
2 citations
,
October 2022 in “Frontiers in genetics” Late diagnosis of congenital adrenal hyperplasia can greatly affect physical development, gender identity, and sexual health.
1 citations
,
March 2012 in “Journal of pediatric & adolescent gynecology” A young girl with high testosterone was thought to have a tumor but actually had PCOS, which was treated with birth control pills.
April 2019 in “Journal of the Endocrine Society” A 12-year-old boy with PAIS successfully developed male characteristics using high-dose testosterone and anastrozole.
55 citations
,
August 2008 in “Reviews in endocrine and metabolic disorders” Nonclassic adrenal hyperplasia is a genetic condition that can cause early puberty and fertility problems, treated with specific steroids.
17 citations
,
February 2014 in “Pediatric Research” 37 citations
,
June 2011 in “Pediatrics in Review” Puberty is driven by hormonal changes, mainly influenced by genetics, nutrition, and body fat.
December 1981 in “Pediatric Research” 11 citations
,
January 2011 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism” Adolescents and young adults with Prader-Willi syndrome show a range of sexual interests and behaviors.
2 citations
,
March 2016 in “Serbian Journal of Dermatology and Venerology” A six-year-old boy with excessive hair growth and other symptoms may have a genetic link on chromosome 17q, requiring regular medical follow-ups.