Search

for
Search:

GlossaryHLA Class I

proteins on cell surfaces presenting peptides to immune T cells

HLA Class I, also known as Human Leukocyte Antigen Class I, refers to a group of proteins found on the surface of almost all cells in the body. These proteins play a crucial role in the immune system by presenting fragments of proteins (peptides) from inside the cell to T cells, which helps the immune system recognize and respond to infected or abnormal cells, such as those infected by viruses or transformed into cancer cells.

Related Terms

Sort by

Research

30 / 1000+ results

Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A*33:01; B*14:02; C*08:02 as a Genetic Marker

research Study of Human Leukocyte Antigen ( HLA ) in 13 cases of familial frontal fibrosing alopecia: CYP 21A2 gene p.V281L mutation from congenital adrenal hyperplasia linked to HLA class I haplotype HLA ‐ A33:01 ; B14:02; C*08:02 as a genetic marker

7 citations , January 2019 in “Australasian Journal of Dermatology”

A genetic marker linked to a type of hair loss was found in most patients studied.

research Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata

36 citations , July 2007 in “Journal of Investigative Dermatology”

Certain HLA class II alleles increase or decrease the risk of alopecia areata.

research Major Histocompatibility Complex Class I Chain-Related Gene A Polymorphisms and Extended Haplotypes Are Associated with Familial Alopecia Areata

44 citations , December 2005 in “Journal of Investigative Dermatology”

Certain genetic markers, especially the MICA gene, are linked to alopecia areata.

research Cell Surface B2m-Free Human Leukocyte Antigen (HLA) Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?

3 citations , July 2023 in “Biomolecules”

B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.

research Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege

March 2024 in “International Journal of Cosmetic Science”

Dandruff is linked to increased T cells and weakened immune protection in hair follicles.

Exacerbation of Alopecia Areata During Pegylated Interferon Alpha-2b and Ribavirin Therapy, Possibly Due to the Collapse of Hair Follicle Immune Privilege

research Exacerbation of alopecia areata during pegylated interferon alpha-2b and ribavirin therapy, possibly due to the collapse of hair follicle immune privilege

10 citations , September 2014 in “European Journal of Dermatology”

A woman's hair loss worsened after starting hepatitis C treatment due to immune changes in her hair follicles.

research Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata

32 citations , March 2015 in “The Journal of Clinical Endocrinology & Metabolism”

Alopecia areata is linked to thyroid autoimmunity but not type 1 diabetes.

research Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege

27 citations , January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Somatostatin may help protect hair follicles from immune attacks.

research The role of somatostatin expression in hair follicle immune privilege

January 2012

Somatostatin helps hair follicles suppress immune responses, which might aid in treating certain hair loss conditions.

research Alopecia areata update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

Alopecia Areata: Clinical Review and Treatment Approaches

research Alopecia Areata

50 citations , March 2000 in “American Journal of Clinical Dermatology”

Alopecia Areata has no guaranteed treatment for hair regrowth, but options like corticosteroids and minoxidil are used, with future research focusing on genetic and immune therapies.

research Alopecia areata update

49 citations , April 2000 in “Journal of The American Academy of Dermatology”

Despite progress in treatment, the exact cause of Alopecia areata is still unknown.

Alopecia Areata: Pathogenesis, Genetic Factors, and Treatments Using Mouse Models

research Alopecia Areata

24 citations , January 2008 in “KARGER eBooks”

The document concludes that ongoing research using animal models is crucial for better understanding and treating Alopecia Areata.

The Etiology and Pathogenesis of Alopecia Areata

research The aetiology and pathogenesis of alopecia areata

17 citations , July 1994 in “Journal of Dermatological Science”

The cause of alopecia areata is likely a mix of genetics, immune system issues, and environmental factors, with more research needed to understand it fully.

research Alopecia Areata: A Comprehensive Review of Pathogenesis, Diagnosis, and Emerging Therapeutics

February 2026 in “Journal of Advances in Biology & Biotechnology”

Alopecia areata causes unpredictable hair loss and requires personalized treatment.

research Genetics of Alopecia

April 2012 in “Encyclopedia of Life Sciences”

Different genes are linked to various types of hair loss.

research Pathophysiology of Alopecia Areata in the Pediatric Patient

5 citations , March 2025 in “Pediatric Dermatology”

Alopecia areata in children is caused by the immune system attacking hair follicles due to genetic factors.

research A comparative analysis of immune privilege in pregnancy and cancer in the context of checkpoint blockade immunotherapy

16 citations , March 2018 in “Seminars in Oncology”

The document concludes that pregnancy and cancer share immune evasion tactics, but more research is needed before using checkpoint blockade immunotherapy in pregnant cancer patients to avoid harm to the placenta.

research 307 Computer-assisted epitope prediction revealed potential autoantigens associated with human alopecia areata

April 2018 in “Journal of Investigative Dermatology”

Melanogenesis-related proteins may trigger immune responses in alopecia areata patients.

Adrenal 21-Hydroxylase Gene Mutations in Slovenian Hyperandrogenic Women: Evaluation of Corticotrophin Stimulation and HLA Polymorphisms in Screening for Carrier Status

research Adrenal 21-hydroxylase gene mutations in Slovenian hyperandrogenic women: evaluation of corticotrophin stimulation and HLA polymorphisms in screening for carrier status

19 citations , August 1999 in “European journal of endocrinology”

The study concluded that testing hormone levels after stimulation is not reliable for identifying carriers of 21-hydroxylase deficiency; genetic testing is necessary.

research Linking allergy to mercury to HLA and burning mouth syndrome

6 citations , January 2007 in “Journal of the European Academy of Dermatology and Venereology”

Mercury allergy linked to specific genes may contribute to burning mouth syndrome, and silicon might play a role in maintaining healthy hair.

Cutaneous Lupus Erythematosus: Overview and Treatment

research Cutaneous Lupus Erythematosus

January 2017 in “Springer eBooks”

The document concludes that Cutaneous Lupus Erythematosus has different forms, is influenced by genetic and environmental factors, and can be treated with various medications, but more targeted therapies are needed.

Human Gene Correlation Analysis: A Tool for the Identification of Transcriptionally Co-Expressed Genes

research Human gene correlation analysis (HGCA): A tool for the identification of transcriptionally co-expressed genes

24 citations , June 2012 in “BMC Research Notes”

The HGCA tool helps identify genes that work together by analyzing their co-expression patterns.

research Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

115 citations , March 2019 in “Nature Communications”

Frontal fibrosing alopecia is linked to four genetic areas, especially the HLA-B*07:02 allele.

Endocrinology and Auxology of Siblings with Non-Classical Congenital Adrenal Hyperplasia

research Endocrinology and auxology of sibships with non-classical congenital adrenal hyperplasia.

13 citations , May 1996 in “Archives of Disease in Childhood”

Siblings with signs of virilization should be tested for non-classical congenital adrenal hyperplasia, which does not affect adult height but may impact fertility and well-being if untreated.

Urinary 5-Ene-Steroid Excretion in Non-Classical Congenital Adrenal Hyperplasia Due to 3β-Hydroxysteroid Dehydrogenase Deficiency

research Urinary 5-ene-steroid excretion in non-classical congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency (NC-3BHSD)

3 citations , May 1990 in “Journal of Steroid Biochemistry”

Some women with excess hair growth have a hormone condition that can't be diagnosed by blood or urine tests alone.

Non-Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Revisited: An Update with a Special Focus on Adolescent and Adult Women

research Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency revisited: an update with a special focus on adolescent and adult women

117 citations , May 2017 in “Human Reproduction Update”

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Search

for
Search:

Related Terms

Research

research Study of Human Leukocyte Antigen ( HLA ) in 13 cases of familial frontal fibrosing alopecia: CYP 21A2 gene p.V281L mutation from congenital adrenal hyperplasia linked to HLA class I haplotype HLA ‐ A33:01 ; B14:02; C*08:02 as a genetic marker

research Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata

research Major Histocompatibility Complex Class I Chain-Related Gene A Polymorphisms and Extended Haplotypes Are Associated with Familial Alopecia Areata

research Cell Surface B2m-Free Human Leukocyte Antigen (HLA) Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?

research Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege

research Exacerbation of alopecia areata during pegylated interferon alpha-2b and ribavirin therapy, possibly due to the collapse of hair follicle immune privilege

research Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata

research Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege

research The role of somatostatin expression in hair follicle immune privilege

research Alopecia areata update

research Alopecia Areata

research Alopecia areata update

research Alopecia Areata

research The aetiology and pathogenesis of alopecia areata

research Alopecia Areata: A Comprehensive Review of Pathogenesis, Diagnosis, and Emerging Therapeutics

research Genetics of Alopecia

research Pathophysiology of Alopecia Areata in the Pediatric Patient

research A comparative analysis of immune privilege in pregnancy and cancer in the context of checkpoint blockade immunotherapy

research 307 Computer-assisted epitope prediction revealed potential autoantigens associated with human alopecia areata

research Adrenal 21-hydroxylase gene mutations in Slovenian hyperandrogenic women: evaluation of corticotrophin stimulation and HLA polymorphisms in screening for carrier status

research Linking allergy to mercury to HLA and burning mouth syndrome

research Cutaneous Lupus Erythematosus

research Human gene correlation analysis (HGCA): A tool for the identification of transcriptionally co-expressed genes

research Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

research Endocrinology and auxology of sibships with non-classical congenital adrenal hyperplasia.

research Urinary 5-ene-steroid excretion in non-classical congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency (NC-3BHSD)

research Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency revisited: an update with a special focus on adolescent and adult women

research Non-classic congenital adrenal hyperplasia

research Classic Sweet sydrome: A case report

research Homoeopathic intervention in classic case of alopecia areata: A case study