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Both oral contraceptives reduced hirsutism in PCOS patients, but adding metformin showed no extra benefit.

Testosterone therapy for transmasculine individuals is generally safe with medical supervision, improves mental health, and has mixed effects on physical health.

Cross-sex hormone treatment in transsexual individuals helps understand how sex hormones affect diseases like heart disease and diabetes.

Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Normal levels of DHT can reduce belly fat and increase muscle, but too much can lead to hair loss, prostate issues, and possibly heart disease.

Anabolic steroids may help prevent aging effects by reducing toxicity, not by their usual functions.

Testosterone therapy for postmenopausal women appears safe and may protect against heart disease, but requires constant monitoring and more research for long-term effects.

Sex hormone treatments can increase muscle mass in older adults but have inconsistent effects on muscle function and may carry cardiovascular risks.

HPT axis hormones boost mitochondrial function and growth in hair follicles, potentially aiding hair health.

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Modified steroidal inhibitors showed promise in treating hormone-dependent cancers.

Lifestyle changes are more effective than medication for reducing type 2 diabetes risk.

MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.

Hirsutism in women is linked to PCOS and can cause health issues if untreated.

Menopause and aging can affect women's quality of life and sexuality, but hormone therapies may help alleviate these issues.

Cyproterone acetate with estradiol improved women's self-confidence and emotional well-being without a difference between oral or transdermal methods, but younger women preferred the oral method.

Phytoconstituents from Cyperus Rotundus may help treat hirsutism by interacting with the 5 α reductase enzyme.

Dihydrotestosterone boosts inflammation in fat cells more than testosterone.

Heart-specific steroid metabolism is crucial in cardiac hypertrophy.

Estrogen may help improve COVID-19 outcomes, especially in women.

New male hormonal contraceptives show promise but need more research on long-term effects and funding for larger trials.

Gender-affirming hormone therapy affects metabolism differently based on treatment type.

Certain natural ingredients and lifestyle changes can help manage PCOS symptoms by balancing hormones and improving insulin sensitivity.

Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.

The document concludes that low-dose oral contraceptives and hormonal therapies can manage perimenopause symptoms and reduce some health risks, but lifestyle changes and disease screening are also important.

Lifestyle changes are more effective than medication for reducing type 2 diabetes risk.