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GlossaryU2HR protein

truncated protein inhibiting hair growth gene, affecting follicles

The U2HR protein is a truncated form of the U2HR (U2 Hairless Repressor) gene product, which plays a role in hair growth regulation. It acts as an inhibitor of the hairless (HR) gene, which is crucial for hair follicle cycling and maintenance. By interfering with the HR gene's function, the U2HR protein can potentially lead to conditions like alopecia, where hair growth is disrupted.

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research Poly(rC) binding protein 2 acts as a negative regulator of IRES-mediated translation of Hr mRNA

3 citations , February 2018 in “Experimental and Molecular Medicine/Experimental and molecular medicine”

A protein called PCBP2 controls the production of a hair growth protein by interacting with its genetic message and is linked to hair loss when this control is disrupted.

research The “Bald Mill Hill” Mutation in the Mouse Is Associated with an Abnormal, Mislocalized HR bmh Protein

1 citations , July 2007 in “Journal of Investigative Dermatology”

The mutation causes hairless mice due to mislocalized and dysfunctional HR protein.

research The abnormal, mis-localizated HR bmh protein associates with members of the protein processing machinery in the cytoplasm

January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

The mutant HR bmh protein mis-localizes in cells, affecting skin and hair development.

research In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis

May 2023 in “Pharmaceuticals”

Three specific mutations in the LIPH gene can cause hair loss by damaging the protein's structure and function.

research Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers

15 citations , May 2017 in “Journal of Cellular Biochemistry”

The hairless protein is important for skin, hair, and may influence cancer development.

Diagnostic Value of VDR in Bone Metastasis and Prognosis of Patients with Breast Cancer and Expression Correlation Between Vitamin D Receptor and Hairless Protein

research Diagnostic Value of VDR in Bone Metastasis and Prognosis of Patients with Breast Cancer and Expression Correlation between Vitamin D Receptor and Hairless Protein

6 citations , November 2021 in “Oncology Research and Treatment”

Low Vitamin D receptor levels in breast cancer are linked to worse outcomes and more bone metastases, and could be a marker for prognosis.

research The Mammalian Hairless Protein as a DNA Binding Phosphoprotein

6 citations , June 2016 in “Journal of cellular biochemistry”

The Hr protein binds to DNA, interacts with p53, and affects cell cycle genes.

research Mechanism of JmjC-containing protein Hairless in the regulation of vitamin D receptor function

5 citations , September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease”

Hairless protein helps control hair growth by regulating vitamin D receptor activity.

research Transgenic mice display hair loss and regrowth overexpressing mutant Hr gene

January 2017 in “Jikken doubutsu ihou/Jikken doubutsu/Experimental animals/Jikken Dobutsu”

Mice with a changed Hr gene lose and regrow hair due to changes in the gene's activity.

research Relationship of a Novel c.429delC Deletion in Hairless Gene HR with Alopecia in Two Families from Southern Punjab, Pakistan

August 2020 in “Pakistan Journal of Zoology”

A new mutation in the Hairless gene causes hair loss in two Pakistani families.

research Hairless protein of Jumonji family and hair loss

January 2009

Mutations in the hairless protein gene cause hair loss.

research Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

Vitamin D receptor and hairless protein are essential for hair growth.

research Hairless triggers reactivation of hair growth by promoting Wnt signaling

137 citations , September 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

78 citations , November 2005 in “Endocrinology”

Hairless protein can block vitamin D activation in skin cells.

research Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation

74 citations , September 2006 in “Cell Cycle”

The HR protein's role as a repressor is essential for controlling hair growth.

research Novel Hairless Mutations in Two Kindreds with Autosomal Recessive Papular Atrichia

66 citations , December 1999 in “Journal of Investigative Dermatology”

New mutations in the hairless gene may cause hair loss and affect bone development.

research Thehairless gene of the mouse: Relationship of phenotypic effects with expression profile and genotype

52 citations , October 1999 in “Developmental Dynamics”

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.

research Interactions of the Vitamin D Receptor with the Corepressor Hairless

42 citations , July 2007 in “Journal of Biological Chemistry”

Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.

research Atrichia with papular lesions resulting from a novel insertion mutation in the human hairless gene

19 citations , May 2006 in “Clinical and Experimental Dermatology”

Researchers found a new mutation causing total hair loss from birth.

research A novel missense mutation in the mouse hairless gene causes irreversible hair loss: Genetic and molecular analyses of Hrm1Enu

18 citations , February 2006 in “Genomics”

A new genetic mutation in mice causes permanent hair loss and skin wrinkling.

research Marie Unna hereditary hypotrichosis: A Turkish family with loss of eyebrows and a U2HR mutation

11 citations , September 2010 in “American Journal of Medical Genetics - Part A”

A Turkish family with sparse hair and eyebrow loss has a mutation in the U2HR gene linked to Marie Unna hereditary hypotrichosis.

research Kyoto Rhino Rats Derived by ENU Mutagenesis Undergo Congenital Hair Loss and Exhibit Focal Glomerulosclerosis

9 citations , January 2011 in “EXPERIMENTAL ANIMALS”

A new rat strain with a specific gene mutation causes hair loss and kidney issues.

research Commentary on: Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis

5 citations , October 2013 in “Experimental Dermatology”

The commentary explains that a balance of HR protein and putrescine is important for normal hair growth.

research Hairless: A nuclear receptor corepressor essential for skin function

January 2006 in “Advances in developmental biology”

The Hairless gene is crucial for healthy skin and hair growth.

research The role of vitamin D receptor mutations in the development of alopecia

109 citations , June 2011 in “Molecular and Cellular Endocrinology”

Vitamin D receptor mutations can cause alopecia by affecting hair growth genes.

research Genetics of Structural Hair Disorders

17 citations , November 2012 in “Journal of Investigative Dermatology”

The document concludes that over 500 genes are linked to hair disorders and this knowledge is important for creating new treatments.

research Analyse de la régulation du gène Hairless et identification des voies de signalisation affectées chez les mutants «bald Mill Hill».

January 2008 in “HAL (Le Centre pour la Communication Scientifique Directe)”

The mutant HR bmh protein affects hair follicle formation by failing to repress vitamin D receptor activity.

research A unique insertion/duplication in the VDR gene that truncates the VDR causing hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia

37 citations , October 2006 in “Archives of Biochemistry and Biophysics”

A unique gene mutation causes vitamin D-resistant rickets without causing hair loss.

research Unveiling the Roots of Monogenic Genodermatoses: Genotrichoses as a Paradigm

26 citations , December 2011 in “Journal of Investigative Dermatology”

New gene identification techniques have improved the understanding and classification of inherited hair disorders.

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

17 citations , March 2012 in “Journal of biological chemistry/The Journal of biological chemistry”

Hairless protein affects hair follicle structure by regulating the Dlx3 gene.