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GlossaryHuman Outer Root Sheath Cells

cells in hair follicle's outer layer aiding growth and regeneration

Human Outer Root Sheath Cells are a type of cell found in the outer layer of the hair follicle. These cells play a crucial role in the growth and regeneration of hair, as they provide structural support and house stem cells that can differentiate into various cell types needed for hair production.

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Wnt/β-Catenin and ERK Pathway Activation: A Possible Mechanism of Photobiomodulation Therapy with Light-Emitting Diodes That Regulate the Proliferation of Human Outer Root Sheath Cells

research Wnt/β‐catenin and ERK pathway activation: A possible mechanism of photobiomodulation therapy with light‐emitting diodes that regulate the proliferation of human outer root sheath cells

43 citations , September 2017 in “Lasers in Surgery and Medicine”

LED light therapy may help hair growth by activating certain cell pathways.

research VEGF upregulates VEGF receptor-2 on human outer root sheath cells and stimulates proliferation through ERK pathway

23 citations , June 2012 in “Molecular Biology Reports”

VEGF stimulates hair cell growth and increases growth receptor levels through a specific signaling pathway.

research Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles

14 citations , April 2021 in “International journal of molecular sciences”

Mesenchymal stem cells may help treat hair loss by improving hair cell growth and reducing inflammation.

Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways

research 705 Particulate matter induces inflammatory response in human outer root sheath cells via oxidative stress-dependent MAPK and JAK-STAT signaling pathways

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Particulate matter causes inflammation in hair cells, potentially harming hair growth.

Wnt/β-Catenin and ERK Pathway Activation: The Possible Mechanism of Various LED Light Regulating the Proliferation of Human Outer Root Sheath Cells

research Wnt/β-catenin and ERK pathway activation: The possible mechanism of various light-emitting diode light regulates the proliferation of human outer root sheath cells

May 2017 in “Journal of The American Academy of Dermatology”

LED light helps human hair root cells grow and move by activating certain cell pathways.

research P140 Light-emitting diode light regulates the proliferation of human outer root sheath cells via Wnt/β -catenin and ERK pathway

January 2016 in “프로그램북(구 초록집)”

LED light promotes hair growth by stimulating cell proliferation and reducing cell death.

research Trichilemmoma.Cell biology of the normal human outer root sheath.

January 1995 in “Skin Cancer”

The outer root sheath in hair follicles changes during growth, with different keratinization processes in its layers.

research FORMATION OF A REGULAR NEO-EPIDERMIS BY CULTURED HUMAN OUTER ROOT SHEATH CELLS GRAFTED ON NUDE MICE

14 citations , April 1995 in “Transplantation”

Human hair follicle cells can be used to help heal and replace skin.

Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cells

research Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cell

9 citations , June 2020 in “Tissue Engineering and Regenerative Medicine”

HHORSC exosomes and PL improve hair growth treatment outcomes.

research Differentiation of nestin-negative human hair follicle outer root sheath cells into neurons in vitro

5 citations , January 2017 in “Molecular Medicine Reports”

Human hair follicle cells can be turned into neural stem cell-like cells, which might help treat brain diseases.

research A new in vitro culture system to produce a fully differentiated epidermis from human hair follicle outer root sheath cells

2 citations , January 1989

Researchers developed a method to grow skin-like tissue from hair cells.

research Organotypic culture of outer root sheath cells from human hair follicles using a new culture device

35 citations , August 1987 in “In Vitro Cellular & Developmental Biology - Plant”

The new device improves human hair follicle cell growth and differentiation.

MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations , December 2020 in “Frontiers in cell and developmental biology”

miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.

research Immunolocalization of telomerases in human hairs identifies proliferating cells in the bulb matrix and outer root sheath

March 2024 in “Tissue and cell/Tissue & cell”

Telomerase-positive cells are mainly in the bulb matrix and outer root sheath of hair follicles.

research Interferon β Secreted from Human Hair Dermal Papilla Cells Inhibits the Growth of Outer Root Sheath Cells Cultured in Vitro

13 citations , January 2002 in “Biochemical and biophysical research communications”

Interferon β from hair cells stops the growth of other hair cells.

research Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro

135 citations , November 1987 in “Differentiation”

Outer root sheath cells consistently express certain keratins influenced by their environment.

research VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro

35 citations , October 2013 in “Journal of Dermatological Science”

VEGF165 influences hair follicle cell growth and movement through VEGFR-2 activation.

research Human hair follicle cells of outer root sheath maintain their genuine keratin expression in vitro

1 citations , June 1986

research Effect of thioredoxin reductase 1 on glucocorticoid receptor activity in human outer root sheath cells

34 citations , March 2007 in “Biochemical and Biophysical Research Communications”

Thioredoxin reductase 1 does not affect glucocorticoid receptor activity in hair follicle cells.

Novel ALK5 Inhibitor TP0427736 Reduces TGF-β Induced Growth Inhibition in Human Outer Root Sheath Cells and Elongates Anagen Phase in Mouse Hair Follicles

research Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles

14 citations , January 2017 in “Pharmacological Reports”

TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.

research Effect of Minoxidil Sulfate on the Growth of Human Anagen Hair Follicles Grown in Collagen Gels, and on the Colony Growth of Human Cultured Outer Root Sheath Cells in vitro.

1 citations , January 1992 in “The Nishinihon Journal of Dermatology”

Minoxidil sulfate did not enhance hair growth or cell proliferation at tested levels.

research [An immunohistochemical study on cell differentiation in the outer root sheath of the normal human anagen hair follicles with antikeratin monoclonal antibodies].

6 citations , December 1990 in “PubMed”

Keratinocytes in hair follicles differentiate similarly to skin cells, with specific patterns in different regions.

research Sex hormones and antiandrogens influence in vitro growth of dermal papilla cells and outer root sheath keratinocytes of human hair follicles

9 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Sex hormones and antiandrogens can either stimulate or inhibit human hair follicle cell growth depending on the dose.

research Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells

16 citations , July 1994 in “Journal of Dermatological Science”

Minoxidil sulfate and pinacidil may promote hair growth through increased blood flow, not by activating potassium channels.

research Melanocyte Chitosan/Gelatin Composite Fabrication with Human Outer Root Sheath-Derived Cells to Produce Pigment

5 citations , March 2019 in “Scientific Reports”

The technique can isolate cells to help treat skin pigmentation issues.

research Outer root sheath (ORS) cells organize into epidermoid cyst-like spheroids when cultured inside Matrigel: a light-microscopic and immunohistological comparison between human ORS cells and interfollicular keratinocytes

36 citations , January 1994 in “Cell and Tissue Research”

Conditioned Media Obtained from Human Outer Root Sheath Follicular Keratinocyte Culture Activates Signalling Pathways That Contribute to Maintenance of Hair-Inducing Capacity and Increases Trichogenicity of Cultured Dermal Cells

research Conditioned media obtained from human outer root sheath follicular keratinocyte culture activates signalling pathways that contribute to maintenance of hair-inducing capacity and increases trichogenicity of cultured dermal cells

6 citations , July 2012 in “Experimental Dermatology”

The substance from human hair root cells can help maintain hair growth and make skin cells more capable of growing hair.

Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles

research Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles.

12 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Certain sex hormones and antiandrogens can either slow down or speed up the growth of human hair follicle cells depending on their concentration.

research Improved isolation of outer root sheath cells from human hair follicles and their proliferation behavior under serum-free condition

13 citations , February 2007 in “Biotechnology and Bioprocess Engineering”

research Soluble factors from human hair papilla cells and dermal fibroblasts dramatically increase the clonal growth of outer root sheath cells

62 citations , June 1993 in “Archives of Dermatological Research”