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research Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature

15 citations , June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mice with extra human KLK14 had hair and skin problems, including weaker cell bonds and inflammation, linked to Netherton syndrome.

research Trichocyte Keratin-Associated Proteins (KAPs)

17 citations , January 2018 in “Advances in experimental medicine and biology”

research Ontogeny and regional variability of keratin 2e (K2e) in developing human fetal skin: a unique spatial and temporal pattern of keratin expression in development

19 citations , April 1999 in “British Journal of Dermatology”

Keratin 2e shows a unique pattern in developing fetal skin, different from other keratins.

research Activated Kras Alters Epidermal Homeostasis of Mouse Skin, Resulting in Redundant Skin and Defective Hair Cycling

29 citations , October 2010 in “Journal of Investigative Dermatology”

Activating Kras in mouse skin causes excess skin and hair loss.

research Insights on the mechanical behavior of keratin fibrils

13 citations , May 2016 in “International journal of biological macromolecules”

Keratin's mechanical properties are influenced by hydrogen bonds and secondary structure, and can be improved with the SPD-2 peptide.

Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

research Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

98 citations , June 2001 in “Journal of biological chemistry/The Journal of biological chemistry”

A cluster of sulfur-rich hair protein genes was found on chromosome 17.

Manipulation of Stem Cell Divisional Behavior: Selectively Promoting Asymmetric and Symmetric Keratinocyte Divisions In Vitro

research 876 Manipulation of stem cell divisional behavior: Selectively promoting asymmetric and symmetric keratinocyte divisions in vitro

April 2017 in “Journal of Investigative Dermatology”

Scientists can control how skin stem cells divide by using different treatments.

research Keratin 17 in disease pathogenesis: from cancer to dermatoses

62 citations , October 2018 in “Journal of pathology”

Keratin 17 is linked to various diseases, including cancer and skin conditions, and may be a target for diagnosis and treatment.

research Expression of type I hair keratins in follicular tumours

26 citations , May 2001 in “British Journal of Dermatology”

Pilomatrixomas likely originate from the hair matrix due to changes in hair keratin expression.

research Immunolocalization of junctional proteins in human hairs indicates that the membrane complex stabilizes the inner root sheath while desmosomes contact the companion layer through specific keratins

12 citations , January 2013 in “Acta Histochemica”

Junctional proteins stabilize the inner root sheath and connect the companion layer in human hair.

research A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21.

61 citations , September 1994 in “Journal of Medical Genetics”

Pachyonychia congenita is linked to a keratin gene on chromosome 17.

research The role of cathepsin E in terminal differentiation of keratinocytes

15 citations , April 2011 in “Biological Chemistry”

Cathepsin E is crucial for normal skin cell differentiation and development.

research The Fate of Trichohyalin

135 citations , October 1997 in “Journal of biological chemistry/The Journal of biological chemistry”

Trichohyalin is modified by enzymes to form strong structures in hair cells.

research Trans glutaminase-mediated cross-linking in mammalian epidermis

44 citations , January 1984 in “Molecular and Cellular Biochemistry”

research Familial congenital generalized hypertrichosis

1 citations , January 2013 in “Indian journal of dermatology, venereology, and leprology”

A girl inherited excessive body hair from her mother and grandmother.

research A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle

139 citations , December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

K6hf is a unique protein found only in a specific layer of hair follicles.

research Inducible cre-mediated N-ras activation and PTEN inactivation in transgenic mouse melanocytes requires keratinocyte hyperplasia to elicit a melanocyte pathology

January 2005 in “Enlighten: Publications (The University of Glasgow)”

Melanocyte pathology requires keratinocyte hyperplasia and regulation dysfunction.

research Catagen in the hairless house mouse

17 citations , November 1967 in “American Journal of Anatomy”

Hairless mice have longer hair follicles and abnormal structures during the catagen phase.

research Differentiation and Apoptosis in Pilomatrixoma

9 citations , January 2011 in “American Journal of Dermatopathology”

Pilomatrixoma involves abnormal hair keratin production and cell death, causing debris and cysts.

research Histopathological Analysis on keratin2-6 g Expression in Hair Mutant Mouse Hague

January 2002 in “Proceedings of The Japanese Society of Animal Models for Human Diseases”

Keratin2-6g is crucial for hair follicle development, with mutations causing cell degeneration and vacuolation.

research Transient expression of keratin 19 is induced in originally negative interfollicular epidermal cells by adhesion of suspended cells.

25 citations , October 2005 in “PubMed”

Keratin 19 expression in certain skin cells is temporary and not a reliable stem cell marker.

research AUTOSOMAL DOMINANT INHERITANCE OF ALOPECIA CONGENITA WITH KERATOSIS PALMO-PLANTARIS

April 1977 in “Pediatric Research”

research Investigating the role of keratin proteins and microbial associations in hereditary and pathogenic alopecia

October 2024 in “Archives of Dermatological Research”

research Clinical Findings, Cutaneous Pathology, and Response to Therapy in 21 Patients With Keratosis Pilaris Atrophicans

78 citations , April 1994 in “Archives of dermatology”

The study found that Keratosis Pilaris Atrophicans is a genetic skin condition that starts in childhood, involves inflammation and scarring, and current treatments are only somewhat effective.

research Is thyrotropin-releasing hormone a novel neuroendocrine modulator of keratin expression in human skin?

10 citations , February 2013 in “British Journal of Dermatology”

Thyrotropin-releasing hormone may help control skin and hair growth and could aid in treating related disorders.

research Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair

10 citations , December 2015 in “International Journal of Molecular Sciences”

PDCD4 is important for controlling skin cell growth and healing.

research Hair follicle neogenesis in adult skin

August 2018 in “The Molecular Biology Society of Japan”

research Regular expression of hair follicle keratins as crucial factors in tissue engineering of hair follicles

November 2011 in “International Society of Hair Restoration Surgery”

Keratins are key to developing and regenerating hair follicles for treating hair loss.

research Generalized hypertrichosis associated with the use of interleukin 17 blockers in 2 patients with psoriasis

3 citations , May 2020 in “JAAD Case Reports”

Two patients with psoriasis grew extra hair after using certain psoriasis medications.

research Skin Keratins

54 citations , November 2015 in “Methods in enzymology on CD-ROM/Methods in enzymology”

Keratins are important for skin cell health and their problems can cause diseases.

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