2 citations
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October 2016 in “Nutrition in clinical practice” Vitamin B12 deficiency can cause facial dark spots that go away with treatment.
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January 1963 in “PubMed” 16 citations
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February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
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November 2003 in “Journal of the American Academy of Dermatology” Iron therapy cured the boy's hair color issue.
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January 2009 in “World Journal of Gastroenterology” A woman with both Cronkhite-Canada syndrome and myelodysplastic syndrome improved significantly with corticosteroid treatment.
January 2024 in “Australasian journal of dermatology (Print)” A boy's hair turned red because of genetic mutations, not lack of zinc.
January 2021 in “Biomedical Research-tokyo” Reticulocyte hemoglobin content is the best indicator of iron deficiency causing hair loss in women.
January 1996 in “Journal of Investigative Dermatology” 9 citations
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June 2017 in “The American journal of dermatopathology/American journal of dermatopathology” The study found increased skin pigmentation and variable melanocyte density in a patient with Addison's disease.
12 citations
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November 1970 in “Postgraduate Medical Journal” Some skin diseases and anaemia are related, and treating the skin condition can often improve the anaemia.
April 2015 in “Archives of disease in childhood” A chubby child can still be malnourished.
66 citations
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November 1997 in “Nutrition” One-third of patients on home nutrition had micronutrient deficiencies, with iron deficiency being most common, but serious issues were rare.
74 citations
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July 1995 in “PubMed” Lowering homocyst(e)ine levels can reverse skin and hair lightening by restoring enzyme activity needed for pigmentation.
January 1994 in “中医杂志:英文版” Hair trace element levels can guide new treatments for aplastic anemia.
October 2019 in “European Journal of Dermatology” The boy's hair and skin color differences are due to a pigmentation disorder.
1 citations
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May 2012 in “Clinical and Experimental Dermatology” Iron can be present in hair color changes without overall iron deficiency.
January 2026 in “JCEM Case Reports” A rare case of Cushing's syndrome and pheochromocytoma requires careful re-evaluation to avoid complications.
6 citations
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July 2019 in “Experimental Dermatology” Skin can produce blood cells, often due to disease, which might lead to new treatments for skin and blood conditions.
August 2023 in “Gastroenterology” A 78-year-old man with Cronkhite-Canada syndrome improved significantly after treatment and remains symptom-free.
2 citations
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March 2023 in “JAAD case reports” Hair repigmentation can indicate malignancy and should be investigated.
1 citations
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February 2023 in “Pediatrician (St Petersburg)” Early iron deficiency can lead to anemia during puberty, so it's important to address it early.
21 citations
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June 1991 in “Journal of Inherited Metabolic Disease” Selenium deficiency caused symptoms in a child, which improved with selenium supplements.
June 2025 in “British Journal of Dermatology” Segmented hair color changes can indicate active alopecia areata.
3 citations
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December 1956 in “PubMed” 11 citations
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July 2014 in “Clinical Rheumatology” Cyclophosphamide often causes gastrointestinal issues, hair loss, and low blood cell counts in Chinese patients with autoimmune diseases.
12 citations
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June 2006 in “Pediatric blood & cancer” A 16-year-old boy had pernicious anemia, autoimmune hemolytic anemia, and later developed alopecia areata.
5 citations
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August 2012 in “Archives of Dermatology” The immune system can cause permanent skin and hair whitening by attacking pigment cells.
2 citations
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March 2017 in “Sultan Qaboos University medical journal” An infant had two different natural hair colors on the scalp with no health issues.
June 2017 in “Journal of clinical and investigative dermatology” Red blood cell folate levels are reliable indicators of long-term folate status in alopecia areata patients.
1 citations
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July 2017 in “PubMed” Two patients with Cronkhite-Canada syndrome achieved remission after treatment.