October 2010 in “Journal of Men's Health” Some patients may experience lasting sexual dysfunction, depression, and other side effects from 5α-reductase inhibitor therapy.
11 citations
,
October 2020 in “General and comparative endocrinology” Male C57BL/6 mice show age-related fluctuations in certain hormones and their ratios in both blood and hair.
April 2020 in “Journal of the Endocrine Society” A woman's severe hirsutism was caused by Leydig cell tumors in her ovaries, which improved after surgery.
24 citations
,
September 2001 in “Journal of The American Academy of Dermatology” Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.
April 2010 in “The Journal of Urology” Human prostate cells produce more WISP1/CCN4 when there's not enough oxygen.
Testosterone's health effects are complex and not definitively understood.
July 2011 in “British Journal of Dermatology” Hormone treatment caused hair loss, finasteride helped regrowth.
11 citations
,
January 1991 in “Urology” New hormonal treatments for enlarged prostate show promise for safer, effective non-surgical options.
37 citations
,
November 2002 in “Biology of Reproduction” Prenatal antiandrogen treatment altered hormone levels in adult spotted hyenas, affecting males and females differently.
Testosterone therapy can safely and effectively treat symptoms like low libido and fatigue in women, especially after menopause.
February 2025 in “Cureus” Early diagnosis and treatment of NCCAH can improve symptoms and fertility.
1 citations
,
January 2010 in “Endocrine abstracts”
17 citations
,
February 2020 in “Journal of Pediatric and Adolescent Gynecology” Early medical support for transgender youth is important for their health, with low regret for gender-affirming hormone use and a need for knowledgeable care providers.
2 citations
,
June 2024 in “Anti-Aging Eastern Europe” PCOS symptoms vary by age, affecting diagnosis and treatment.
February 2016 in “PubMed” Properly administered testosterone therapy is safe and effective but often not covered by insurance.
2 citations
,
January 2012 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” Hirsutism and alopecia during menopause can be diagnosed and treated with specific hormonal and topical therapies.
October 2025 in “Zenodo (CERN European Organization for Nuclear Research)” Hormonal imbalances in women can cause acne, excess hair growth, and hair loss, needing combined medical and mental health care.
October 2023 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Hyperandrogenism increases heart disease risk in premenopausal women, but this risk is linked to obesity in postmenopausal women.
9 citations
,
January 2009 in “PubMed” Finasteride treatment can decrease certain steroids and increase others, possibly leading to depression symptoms in some cases.
4 citations
,
December 2022 in “Frontiers in Endocrinology” Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.
April 2020 in “Journal of the Endocrine Society” Non-classic congenital adrenal hyperplasia (NCCAH) can mimic PCOS and requires genetic testing for proper diagnosis and treatment.
March 2004 in “Current Sexual Health Reports” Testosterone's role in women's sex drive is unclear and needs more research, as low levels don't always mean less sexual interest and high levels can cause side effects.
14 citations
,
September 2015 in “Expert Opinion on Therapeutic Targets” The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.
January 2021 in “touchREVIEWS in Endocrinology” Surgery successfully treated a hidden ovarian tumor causing hair loss and excess hair growth in a postmenopausal woman.
82 citations
,
May 2016 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.
April 2015 in “The FASEB Journal” Blocking androgens at birth reduces sexual motivation in male rats.
6 citations
,
January 1984 in “PubMed” Spironolactone treatment reduced hair growth and androgen levels in hirsute women, but the overall effectiveness was just adequate.
6 citations
,
June 2017 in “Reproductive Biomedicine Online” Chinese women with PCOS have higher androgen levels, which change with age and weight.
2 citations
,
March 2012 in “Nature Reviews Endocrinology” The body's change of testosterone into DHT is not necessary for testosterone's muscle and sexual effects.
9 citations
,
June 2014 in “European Journal of Obstetrics & Gynecology and Reproductive Biology” Blood AMH levels are higher in women with PCOS than in those with other similar conditions.