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The enzyme RDH12 plays a role in vision and retinal disease, with mutations leading to early onset visual loss and blindness, but the exact disease mechanism is unclear and there are no treatments yet.

Targeting ornithine decarboxylase can help prevent skin cancer.

Restoring immune privilege in hair follicles could help treat certain types of hair loss.

The hr gene is crucial for skin and hair health, with mutations causing hair disorders.

TPA strongly increases ODC activity in certain skin cells, potentially aiding tumor growth.

The MBTPS2 gene variant c.970+5G>A is a common mutation causing IFAP syndrome.

Two siblings had a rare immune disorder caused by a FOXN1 gene mutation.

NIPP1 is important for healthy skin and could help treat skin inflammation.

New genetic variants linked to inherited ichthyoses were identified, offering insights for potential gene therapy.

Mutations in the DSG4 gene cause specific hair and scalp issues.

Immunotherapy for cancer caused a patient to develop a condition affecting hormone production, requiring ongoing hormone replacement therapy.

Intestinal intraepithelial lymphocytes are crucial for gut immunity and maintaining the mucosal barrier.

Hair samples can be used to create stem cells easily and non-invasively.

Type I and Type II keratin chains can form heterodimers despite sequence differences.

iPSCs help understand and treat neurodevelopmental disorders.

Type 1/17 inflammation in psoriasis increases skin cell growth due to a molecule that could be a new treatment target.

A man with KID syndrome developed a rare cancer in a long-term skin infection.

QLT0267 stops hair follicle cell growth and movement.

GLI2 activates GLI1, promoting skin tumor growth and hair development.

EZH1 and EZH2 are crucial for healthy hair growth and skin repair.

ILC1-like cells can cause alopecia areata by disrupting hair follicle immunity, suggesting a new treatment approach.

A new gene mutation causes insulin resistance in a girl and her mother.

ILC1-like cells can cause alopecia areata by themselves.

The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.

Dermal EZH2 controls skin cell growth and differentiation in mice.

ODC expression in mouse skin and tumors is varied and can be inhibited by retinoic acid or cycloheximide.

Overexpression of IKZF1 and Ikaros causes hair loss in mice similar to alopecia areata.

Future research on ectodysplasin should explore its role in diseases, stem cells, and evolution, and continue developing treatments for genetic disorders like hypohidrotic ectodermal dysplasia.

A specific gene mutation causes congenital hair loss.