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2-DG reduces seizures by enhancing brain inhibition through specific receptor activation.

Some natural compounds from Iris plants can block enzymes related to certain disorders, with a few affecting both targeted enzymes.

D'orenone stops root hair growth by disrupting auxin transport, but adding auxin can reverse this.

Different PADI isoforms help cells develop diverse functions.

The OVOL1-OVOL2 axis is important for hair follicle differentiation and can help diagnose certain hair-related tumors.

TPA strongly increases ODC activity in certain skin cells, potentially aiding tumor growth.

N-oxides are important in medicine for improving drug properties and targeting.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

PH-762 shows promise in treating skin cancer by effectively targeting and silencing PD-1 in tumors with minimal side effects.

Mutants of CYP154C2 enzyme significantly improved steroid conversion efficiency.

Inhibiting ODC can prevent UV-induced skin cancer.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

A new antiandrogen compound was made and its detailed three-dimensional shape was described.

Blocking certain receptors in the lungs might help treat a specific type of asthma.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

K6/ODC transgenic mice are effective for quickly identifying cancer-causing chemicals.

A new method efficiently modifies alkenes to create useful medicinal compounds.

The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.

The ID2 gene can help distinguish between sensitizers and irritants in skin cells.

This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Increased ODC expression makes normally tumor-resistant mice more prone to tumor development.

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

A new treatment using a DNA aptamer can promote hair growth by targeting a specific receptor.

Near-infrared probes can safely and effectively image cysteine protease activity for disease diagnosis.

Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.

Myo-inositol and D-chiro-inositol improve hormonal and physical symptoms in teenage girls with PCOS.

The research helps understand how finasteride works and aids drug development.