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research MHC Class I-Like MILL Molecules Are β2-Microglobulin-Associated, GPI-Anchored Glycoproteins That Do Not Require TAP for Cell Surface Expression

16 citations , September 2006 in “The Journal of Immunology”

MILL molecules are unique immune proteins in mice that don't need TAP to appear on cell surfaces.

research Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

81 citations , November 2012 in “Journal of the National Cancer Institute”

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

Analysis of Long Non-Coding and Messenger RNA Expression Profiles in the Skin Tissue of Super Merino and Small-Tailed Han Sheep

research Analysis of the Long Non-Coding and Messenger RNA Expression Profiles in the Skin Tissue of Super Merino and Small-Tailed Han Sheep

August 2024 in “Current Issues in Molecular Biology”

Key genes and RNAs related to hair growth in sheep were identified, aiding future breeding improvements.

research Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis

102 citations , August 2008 in “Genes & Development”

Laminin-511 is crucial for early hair growth and maintaining important hair development signals.

research The distributions of type IV collagen .ALPHA. chains in basement membranes of human epidermis and skin appendages

36 citations , January 2007 in “Archives of Histology and Cytology”

Type IV collagen chains vary in different parts of human skin, with specific patterns linked to melanocytes.

A New Mutation Resulting in the Truncation of the TRAF6-Interacting Domain of XEDAR: A Possible Novel Cause of Hypohidrotic Ectodermal Dysplasia

research A new mutation resulting in the truncation of the TRAF6-interacting domain of XEDAR: a possible novel cause of hypohidrotic ectodermal dysplasia: Figure 1

17 citations , August 2012 in “Journal of Medical Genetics”

A new mutation in the XEDAR gene might cause a rare skin condition called hypohidrotic ectodermal dysplasia.

research Jagged-1+ Skin Tregs Modulate the Innate Immune Response to Wound Healing

June 2024 in “Research Square (Research Square)”

Jagged-1 in skin Tregs is crucial for timely wound healing by recruiting specific immune cells.

research Oxygen, Metabolism, and Regeneration: Lessons from Mice

35 citations , October 2017 in “Trends in Molecular Medicine”

Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.

research 496 Understanding the mechanism of action of secukinumab using lesional hidradenitis suppurativa skin organ culture

November 2024 in “Journal of Investigative Dermatology”

Secukinumab reduces immune activity in hidradenitis suppurativa skin.

research Ligand‐independent Regulation of the hairless Promoter by Vitamin D Receptor^†

10 citations , February 2008 in “Photochemistry and photobiology”

Vitamin D receptor can control the hairless gene linked to hair loss even without vitamin D.

research Group IID, IIE, IIF and III secreted phospholipase A2s

23 citations , August 2018 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

research 0034 Cross-species insights into hair follicle-T cell interactions in discoid lupus erythematosus: A comparison of human, canine and mouse models using spatial transcriptomics

July 2025 in “Journal of Investigative Dermatology”

Discoid lupus erythematosus involves immune activation and fibrosis around hair follicles, with shared pathways across humans, dogs, and mice, suggesting potential treatments for both humans and animals.

research Skin γδ T cell subsets have distinct functions in alopecia areata 3844

November 2025 in “The Journal of Immunology”

Different γδ T cell types have unique roles in causing alopecia areata.

research Resequencing Analyses Revealed Genetic Diversity and Selection Signatures during Rabbit Breeding and Improvement

March 2024 in “Genes”

Genetic analysis of rabbits identified key genes for traits like coat color, body size, and fertility.

research Interactions of the Vitamin D Receptor with the Corepressor Hairless

42 citations , July 2007 in “Journal of Biological Chemistry”

Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.

CYLD Cutaneous Syndrome Tumors Demonstrate Increased NF-kB Signaling and Diminished Collagen Organization

research O19 CYLD cutaneous syndrome tumours demonstrate increased NF-κB signalling and diminished collagen organisation.

July 2023 in “British journal of dermatology/British journal of dermatology, Supplement”

Skin tumors with CYLD cutaneous syndrome show more NF-κB activity and less organized collagen.

research Differential expression of type I IRS keratin genes in three breeds of sheep

January 2012 in “Zhongguo shouyi xuebao”

Sheep breeds show different keratin gene expression in the groin, linked to hair follicle density.

research lncRNAs UC.145 and PRKG1-AS1 Determine the Functional Output of DKK1 in Regulating the Wnt Signaling Pathway in Gastric Cancer

7 citations , May 2022 in “Cancers”

UC.145 may be a new biomarker for predicting gastric cancer.

research 092 Novel biallelic RIPK4 mutations cause ectodermal dysplasia with cutaneous syndactyly

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

New RIPK4 gene mutations were found to cause a type of skin and limb birth defect.

research Expression of Type II Collagen at the Middle Stages of Chick Embryonic and Human Fetal Skin Development

11 citations , June 1994 in “Journal of Investigative Dermatology”

research 560 Isolation of an “early” transit amplifying keratinocyte population in interfollicular human epidermis: a role for CD271 receptor

November 2022 in “Journal of Investigative Dermatology”

Scientists found a new type of skin cell that could help with skin repair and these cells work better with a certain protein.

research The cDNA-deduced amino acid sequence for trichohyalin, a differentiation marker in the hair follicle, contains a 23 amino acid repeat.

39 citations , February 1990 in “The journal of cell biology/The Journal of cell biology”

Trichohyalin, a hair follicle protein, has a part with repeating patterns of 23 amino acids.

research Delta‐6 desaturase knockout mouse illustrates previously undocumented pathology

1 citations , April 2007 in “The FASEB Journal”

Lack of certain fatty acids causes skin, immune, and fertility issues in mice.

research Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

221 citations , July 2012 in “Proceedings of the National Academy of Sciences of the United States of America”

BMAL1 controls skin cell growth and UV damage risk, peaking at night.

research KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia

4 citations , January 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

A faulty KLHL24 gene leads to hair loss by damaging hair follicle stem cells.

research Shifting IRES versus Cap-initiated translation during homeostatic stem cell differentiation and stress

May 2026 in “Science Advances”

The study explores the shift between internal ribosome entry site (IRES) and cap-dependent translation during stem cell differentiation and stress, using an IRES/Cap reporter mouse model. It reveals that caloric stress increases IRES/Cap translation across tissues, and this increase also occurs during normal differentiation of hematopoietic and hair follicle cells. Low IRES utilization is linked to higher multipotent capability, suggesting that cap-dependent translation is associated with greater stemness. The RNA processing protein PTBP1 regulates this translation preference, indicating that modulation of translation initiation is crucial for cell differentiation. The findings underscore the role of IRES-mediated translation in tissue differentiation and regeneration, with potential implications for understanding stem cell function and therapeutic strategies for conditions like hair loss.

The Effect of DNMTs and MBPs on Hypomethylation in Systemic Lupus Erythematosus

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