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ASLAN004 was safe and well-tolerated, supporting further development for treating certain diseases.

pCLCA2 protein may help maintain skin structure and function.

A mutation in the IKZF1 gene causes immune system overactivity, linked to autoimmune diseases like lupus.

LSD1 is essential for healthy skin development and creating the skin's protective barrier.

UC.145 may be a new biomarker for predicting gastric cancer.

Cutaneous lupus patients have higher levels of certain immune cells in their blood and skin.

IL-3 worsens lupus nephritis and blocking it improves kidney health.

Ift20 is essential for hair follicle function and skin cell movement.

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

Ichthyosis with confetti is a genetic skin disorder with consistent ectodermal malformations and various KRT10 gene mutations.

High levels of the protein Flightless I worsen ulcerative colitis symptoms in mice.

CD8+ T cells attack hair follicle stem cells, causing scarring and hair loss.

All parts of the CLASI-A score are important for assessing skin activity in cutaneous lupus erythematosus.

Icariin can regulate macrophages and may help treat inflammation, cancer, bone disorders, and fibrotic diseases.

LRIG1 protein affects hair growth by regulating skin receptors, leading to hair loss when overexpressed.

IL-1β inhibits human hair follicle growth.

The boy's severe skin disorder is caused by two new mutations in his TGM1 gene.

Lower GATA3 levels in mice help hair regrow by changing certain immune cells.

Lrig1 marks a unique group of stem cells in mouse skin that can become different skin cell types.

Laminin-511 is essential for proper melanocyte movement and development in mice.

Delta1 is crucial for controlling skin cell growth and preventing tumors in mice.

Mechanical stress causes ligament thickening through WISP-1 and Hedgehog signaling.

IL-18 signaling helps mature Tregs move into the thymus.

Lipin-1 is important for skin cell differentiation and skin barrier function.

CENPV, a new partner of CYLD, helps regulate ciliary acetylated tubulin and is overexpressed in certain skin tumors.

A substance called poly(I:C) increases a protein called carbonic anhydrase II in skin cells, which might help with skin defense and healing.

IL-9 increases skin cell movement but decreases their ability to invade, and this effect is controlled by cell contractility, not by MMPs.

Polycomb Repressive Complex 1 is crucial for keeping stem cells stable and maintaining healthy adult tissues.

Ixekizumab may be an effective first treatment for a rare skin condition causing hair loss.

miRNAs in the Dlk1-Gtl2 region may improve lamb fur quality.