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Synthesis and Structure–Activity Studies of Side-Chain Derivatized Arylhydantoins for Investigation as Androgen Receptor Radioligands

research Synthesis and structure–activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands

18 citations , April 2001 in “Bioorganic & Medicinal Chemistry Letters”

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

research Determination of rat 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines

4 citations , August 2010 in “Acta Biologica Hungarica”

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

research Synthesis, Biological Evaluation and in silico Studies of Novel 5α-aza-Bhomo-3,5-secosteroids as Potential 5-reductase Inhibitors

October 2016 in “Letters in Drug Design & Discovery”

research Olorofim Effectively Eradicates Dermatophytes In Vitro and In Vivo

7 citations , September 2021 in “Antimicrobial Agents and Chemotherapy”

Olorofim effectively treats fungal skin infections.

Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production

research Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production

17 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.

research Proceedings of the International Conference on Translational and Integrative Medicine

May 2018 in “Digital ProScholar Media eBooks”

The new fluoroquinolone effectively fights certain bacteria.

research N-methylformamide induces multiple organ toxicity in Fischer 344 rats

January 2023 in “Toxicological Research”

research DESIGN AND EVALUATION OF FLUCONAZOLE LOADED ANTIDANDRUFF HAIR GEL

April 2005 in “World Journal of Pharmaceutical and life sciences”

Fluconazole-loaded hair gel may offer a longer-lasting dandruff treatment.

research MICROBIAL OXIDATION OF FINASTERIDE WITH MACROPHOMINA PHASEOLINA(KUCC 730)

3 citations , November 2017 in “International Journal of Pharmacy and Pharmaceutical Sciences”

research Ion pairs of risedronate for transdermal delivery and enhanced permeation rate on hairless mouse skin

34 citations , July 2011 in “International journal of pharmaceutics”

Ion-paired risedronate significantly increases skin penetration without irritation compared to risedronate alone.

research Arginosuccinicaciduria

10 citations , May 1974 in “American journal of diseases of children”

The girl had a rare disorder causing mental and physical symptoms, with weak hair and unclear neurological issues.

(1R,2S)-4-(2-Cyano-Cyclohexyl-Oxy)-2-Trifluoromethyl-Benzonitrile, A Potent Androgen Receptor Antagonist For Stimulating Hair Growth And Reducing Sebum Production

research (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production

14 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.

research Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier

4 citations , December 2024 in “European Journal of Medicinal Chemistry”

New pyrazole-based inhibitors show promise for treating metabolic diseases and other conditions.

The Pharmaceutical Market as Reflected by Patents

research The Pharma Market as Reflected by Patents

December 2011 in “Drug Research”

The document shows the state of pharmaceutical patents as of 1999, focusing on treatments for various diseases.

research [Finasteride--ris of "unintentional doping"].

November 2005 in “PubMed”

research Metabolite screening of aromatic amine hair dyes usingin vitrohepatic models

16 citations , October 2009 in “Xenobiotica”

The tested hair dye ingredients do not form harmful oxidized metabolites in the liver.

research Metabolic pathway of Cis-UCA upon Ultraviolet B (UVB) exposure using ¹H Nuclear Magnetic Resonance (NMR) spectroscopy, Molecular Docking and cell viability of human keratinocytes (HaCaT) cell lines

February 2026 in “UiTM Institutional Repositories (Universiti Teknologi MARA)”

Cis-UCA can form new compounds without enzymes, and sulphide donors reduce its UVB-induced toxicity in skin cells.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

research Assessment of Antidermatophytic Activities of Urtica dioica L againstMicrosporum canis in a Guinea Pig Model

January 2014 in “TSpace”

Urtica dioica L. extract may help treat skin fungus but is less effective than standard treatment.

research The Localization of Dehydrogenase Activity and Sulphydryl Groups in Wool and Hair Follicles by the use of Tetrazolium Salts

17 citations , September 1953 in “Journal of Cell Science”

INT effectively shows enzyme activity and protein groups in wool and hair follicles.

research Direct access to novel chromeno-pyrimidine-N-oxides via tandem base catalyzed double nucleophilic addition/dehydration reaction

7 citations , March 2013 in “Tetrahedron Letters”

New method makes important drug ingredients more easily without needing extra purification steps.

Experimental Assessment of 3-Meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-Alpha-Reductase Inhibitors in Silico and in Vivo Models

research Experimental Assessment of 3-meta-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-α-Reductase Inhibitors in silico and in vivo Models

January 2023 in “Bioorganičeskaâ himiâ”

The new compound is a promising, less toxic alternative to finasteride for treating prostate issues.

research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes

186 citations , December 2011 in “Molecules”

Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.

research Minimum Structural Requirements for Minoxidil Inhibition of Lysyl Hydroxylase in Cultured Fibroblasts

20 citations , January 1994 in “Archives of Biochemistry and Biophysics”

Minoxidil needs specific structure to block lysyl hydroxylase; exploring alternatives may keep benefits without this effect.

Sustainable UV Approaches Supported by Greenness and Whiteness Assessments for Estimating a Recently FDA-Approved Combination for Managing Urologic Disorders: Tukey's Test

research Sustainable UV approaches supported by greenness and whiteness assessments for estimating a recently FDA-approved combination for managing urologic disorders: Tukey's test

October 2023 in “Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy”

New, eco-friendly methods accurately measure TDF and FNS in a new urologic medication.

research Urticarial rush due to finasteride

5 citations , October 2009 in “Allergy”

Finasteride can cause skin rash.

research Importance of Sebaceous Glands in Cutaneous Penetration of an Antiandrogen: Target Effect of Liposomes

62 citations , May 1997 in “Journal of Pharmaceutical Sciences”

Sebaceous glands in the skin play a key role in absorbing the antiandrogen drug RU 58841, especially when it's encapsulated in liposomes.

research Towards sustainable and scalable synthesis of amitriptyline hydrochloride, minoxidil, and pyrrolidinyl diaminopyrimidine oxide

1 citations , May 2025 in “Journal of the Indian Chemical Society”

research Finasteride

1 citations , July 2016 in “Reactions Weekly”

Finasteride can cause itching, burning, and other side effects that may not go away after treatment.

research Novel Quinazoline Derivative Induces Differentiation of Keratinocytes and Enhances Skin Barrier Functions against Th2 Cytokine-Mediated Signaling

2 citations , August 2023 in “Molecules”

SH-340 may improve skin barrier and help treat atopic dermatitis.

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