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GlossaryInflammatory Disorders

body's immune system mistakenly attacks its own tissues

Inflammatory disorders are conditions where the body's immune system mistakenly attacks its own tissues, leading to inflammation, pain, and damage. Examples include rheumatoid arthritis, psoriasis, and inflammatory bowel disease. These disorders can affect various organs and systems, causing symptoms that range from mild to severe, and often require medical management to control inflammation and prevent long-term damage.

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research Physiological Doses of Red Light Induce IL‐4 Release in Cocultures between Human Keratinocytes and Immune Cells

9 citations , August 2017 in “Photochemistry and Photobiology”

Red light at 627 nm can safely trigger IL-4 release in skin cells, potentially helping treat inflammatory skin conditions.

research The role of somatostatin expression in hair follicle immune privilege

January 2012

Somatostatin helps hair follicles suppress immune responses, which might aid in treating certain hair loss conditions.

research Does collapse of immune privilege in the hair-follicle bulge play a role in the pathogenesis of primary cicatricial alopecia?

39 citations , November 2009 in “Clinical and Experimental Dermatology”

Immune privilege collapse in hair follicles may cause permanent hair loss in certain conditions.

research Dermatologic Disorders

June 2018 in “CRC Press eBooks”

Foals can have various skin issues, some genetic, immune-related, or due to infections and allergies.

research Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

115 citations , March 2019 in “Nature Communications”

Frontal fibrosing alopecia is linked to four genetic areas, especially the HLA-B*07:02 allele.

Frontal Fibrosing Alopecia: Clinical Patterns and Associations

research Frontal Fibrosing Alopecia

1 citations , September 2021 in “CRC Press eBooks”

Frontal Fibrosing Alopecia is a hair loss condition mainly affecting postmenopausal women, with unclear causes and various clinical patterns.

Comparative Evaluation of Superficial Cryotherapy Versus Intralesional Triamcinolone in Alopecia Areata at a Tertiary Care Center: A Dermoscopic and Clinical Study in Middle-Aged Adults

research Comparative Evaluation of Superficial Cryotherapy vs Intralesional Triamcinolone in Alopecia Areata at a Tertiary Care Center: A Dermoscopic and Clinical Study in Middle-aged Adults

November 2025 in “The Journal of Medical Sciences”

Intralesional triamcinolone is more effective than cryotherapy for treating alopecia areata in middle-aged adults.

research DataSheet2_Vitiligo: An Autoimmune Skin Disease and its Immunomodulatory Therapeutic Intervention.PDF

December 2021 in “OPAL (Open@LaTrobe) (La Trobe University)”

New therapies like JAK inhibitors and stem cells show promise in treating vitiligo.

Modern Perspectives on Etiopathogenesis of Alopecia Areata and Promising Treatment Approaches

research Modern рerspectives on еtiopathogenesis of аlopecia аreata and рromising treatment аpproaches (Review)

March 2025 in “Ukrainian Journal of Dermatology Venerology Cosmetology”

Alopecia areata may be treated by targeting immune system imbalances.

research The Potential Relevance of the Microbiome to Hair Physiology and Regeneration: The Emerging Role of Metagenomics

11 citations , February 2021 in “Biomedicines”

Bacteria in our hair can affect its health and growth, and studying these bacteria could help us understand hair diseases better.

research Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair

124 citations , June 2020 in “Cell Stem Cell”

Fat cells in the skin help start healing and form important repair cells after injury.

research Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis

51 citations , August 2013 in “The Journal of experimental medicine/The journal of experimental medicine”

Loss of a specific protein in skin cells causes symptoms similar to psoriasis.

Tyrosine Kinase Inhibitors in Dermatology: A Systematic Review

research Tyrosine kinase Inhibitors in Dermatology: A Systemic Review

1 citations , June 2021 in “Journal of dermatology and dermatitis”

Tyrosine kinase inhibitors show promise in treating some skin diseases but their definitive role in dermatology is still unclear.

research Report from the Cicatricial Alopecia Colloquium

15 citations , February 2006 in “Journal of Investigative Dermatology”

More research is needed to understand and treat cicatricial alopecias.

research Phospholipase's role in maintaining and restoring skin and hair health

1 citations , January 2023 in “Elsevier eBooks”

Phospholipases help maintain and restore skin and hair health, potentially leading to new treatments for related conditions.

research Nerve growth factor and burn wound healing: Update of molecular interactions with skin cells

11 citations , August 2023 in “Burns”

Nerve growth factor helps improve healing time and scar quality in burn wounds.

research Does Complement Have a Role in the Pathogenesis of Alopecia Areata?

1 citations , January 2018 in “Skin appendage disorders”

The complement system might be involved in the development of alopecia areata and could lead to new treatments.

research Beyond hair loss: Exploring the link between alopecia areata and non-alcoholic fatty liver disease

March 2026 in “Tropical Doctor”

Alopecia areata and non-alcoholic fatty liver disease might be linked, but more research is needed.

The Impact of HIV-Related Diseases on Pigmented Skin Types

research The impact of human immunodeficiency virus-related diseases on pigmented skin types

7 citations , October 2013 in “British Journal of Dermatology”

HIV can cause skin disorders, which are often the first sign of infection, especially in people with darker skin.

research Reflectance Confocal Microscopy of Adult Periorificial Dermatitis: A Case Report

July 2023 in “Clinical, cosmetic and investigational dermatology”

Reflectance confocal microscopy helped tell periorificial dermatitis apart from similar skin conditions.

research Immune‐Mediated Disorders in Patients With Alopecia Areata: Systematic Review and Meta‐Analysis

7 citations , July 2025 in “International Journal of Dermatology”

Alopecia areata patients have a higher risk of other immune-related diseases.

research Risk of autoimmune diseases in patients with RASopathies: systematic study of humoral and cellular immunity

11 citations , October 2021 in “Orphanet journal of rare diseases”

Patients with RASopathies are at risk for autoimmune disorders and should be routinely screened.

$Lichen Planus – A Refractory Autoimmune Disorder$

research Lichen planus – A refractory autoimmune disorder

April 2023 in “IP Indian journal of clinical and experimental dermatology”

Lichen planus is a chronic autoimmune disease that is hard to treat and more common in women.

Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

research Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

22 citations , June 2012 in “PLOS ONE”

Cholesterol-related compounds can stop hair growth and cause inflammation in a type of scarring hair loss.

research 0041 Comparative multi-omics highlights inflammatory monocyte-derived dendritic cells as key mediators of UVB-induced photosensitivity

July 2025 in “Journal of Investigative Dermatology”

Monocyte-derived dendritic cells play a key role in UVB-induced skin sensitivity and inflammation.

research Markers of inflammation, metabolic disorders, and principles of treatment for alopecia areata in children

January 2025 in “Voprosy praktičeskoj pediatrii”

Janus kinase inhibitors show promise for treating alopecia areata in children.