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GlossaryImmunocytochemistry

technique using antibodies to visualize proteins in cells

Immunocytochemistry (ICC) is a laboratory technique used to detect specific proteins or antigens in cells by using antibodies that bind to them. These antibodies are often linked to a fluorescent dye or an enzyme, which allows scientists to visualize the location and distribution of the target proteins under a microscope. This method is widely used in research and diagnostics to study cell biology, disease mechanisms, and the effects of treatments.

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research Mitochondrial Oxygen Consumption and Immunocytochemistry of Human Dental Pulp Stem Cell Following 808 nm PBM Therapy: A 3D Cell Culture Study

April 2025 in “Journal of Biophotonics”

PBM therapy improves mitochondrial function and promotes tissue regeneration in dental pulp stem cells.

Fine Structure and Immunocytochemistry of Monotreme Hairs, with Emphasis on the Inner Root Sheath and Trichohyalin-Based Cornification During Hair Evolution

research Fine structure and immunocytochemistry of monotreme hairs, with emphasis on the inner root sheath and trichohyalin‐based cornification during hair evolution

15 citations , July 2004 in “Journal of morphology”

Monotreme hair structure and protein distribution are similar to other mammals, but their inner root sheath cornifies differently, suggesting a unique evolution from reptile skin.

research Ultrastructural Localization of Hair Keratins in Human Scalp Hair Shafts as Revealed by Rapid-Freezing Immunocytochemistry.

3 citations , January 1998 in “ACTA HISTOCHEMICA ET CYTOCHEMICA”

Hair keratins are mainly on macrofibrils in the cortex and in the endocuticle in the cuticle.

research Ultrastructural Localization of S100A3, a Cysteine-rich, Calcium Binding Protein, in Human Scalp Hair Shafts Revealed by Rapid-freezing Immunocytochemistry

40 citations , April 1999 in “Journal of Histochemistry & Cytochemistry”

S100A3 protein is mainly found in specific parts of human hair cells.

research Erythematous cutaneous nodules caused by adulterated cocaine

5 citations , September 1989 in “Journal of The American Academy of Dermatology”

Talc in street cocaine can cause immune-reactive skin nodules where injected.

research Highly Efficient Neural Differentiation of CD34-Positive Hair-Follicle-Associated Pluripotent Stem Cells Induced by Retinoic Acid and Serum-Free Medium

4 citations , January 2016 in “Methods in molecular biology”

Hair follicle stem cells can become nerve cells using specific treatments.

research Effects of biomaterials derived from germinated hemp seeds for stressed hair stem cells and immune cells

June 2024

Germinated hemp seed extracts help prevent hair loss and promote hair growth.

research EBS in Children with De Novo Pathogenic Variants Disturbing Krt14

March 2024 in “International journal of molecular sciences”

Three specific genetic variants cause severe skin issues in children with EBS, highlighting the need for early genetic screening.

research Lenalidomide Augments Differentiation of Cultured Hair Follicle Derived Melanocyte Stem Cells Into Functional Melanocytes

April 2023 in “Dermatology practical & conceptual”

Lenalidomide helps hair follicle stem cells turn into melanocytes, which may improve repigmentation in vitiligo.

research Transdifferentiation of rat hair follicle stem cells to epithelium-like cells induced by stroma of limbus corneae

January 2008 in “Di-san junyi daxue xuebao”

Rat hair follicle stem cells can become corneal epithelium-like cells when exposed to rabbit corneal limbal stroma.

Immunocytochemical Localization of Androgen Receptors in the Scalp of the Stumptail Macaque Monkey, a Model of Androgenetic Alopecia

research Immunocytochemical Localization of Androgen Receptors in the Scalp of the Stumptail Macaque Monkey, a Model of Androgenetic Alopecia

13 citations , April 1994 in “Journal of Investigative Dermatology”

Androgen receptors found in monkey scalps, similar to humans, affect hair growth.

research Relationships between hair-follicle afferent terminations and glutamic acid decar☐ylase-containing boutons in the cat's spinal cord

46 citations , April 1987 in “Brain Research”

Hair-follicle nerves in cats' spinal cords can be inhibited by GABA-related connections.

research Distribution of P2X₃‐immunoreactive fibers in hairy and glabrous skin of the rat

41 citations , April 2009 in “Journal of comparative neurology”

P2X₃-IR fibers are widespread in rat skin and likely help detect pain.

research Comparative aspects of the inner root sheath in adult and developing hairs of mammals in relation to the evolution of hairs

20 citations , September 2004 in “Journal of Anatomy”

The inner root sheath evolved to help hair grow safely through the skin in mammals.

A Study of the Expression of Small Conductance Calcium-Activated Potassium Channels (SK1-3) in Sensory Endings of Muscle Spindles and Lanceolate Endings of Hair Follicles in the Rat

research A Study of the Expression of Small Conductance Calcium-Activated Potassium Channels (SK1-3) in Sensory Endings of Muscle Spindles and Lanceolate Endings of Hair Follicles in the Rat

17 citations , September 2014 in “PLoS ONE”

SK2 channels help control sensory signals in rat muscle spindles and hair follicles.

research Fine structure of marsupial hairs, with emphasis on trichohyalin and the structure of the inner root sheath

8 citations , July 2004 in “Journal of morphology”

Marsupial hair structure and keratin distribution are similar to placental mammals.

research Protective Effect of Retinoic acid preconditioning on H2O2-induced Apoptosis in Hair Cell-like Cells

February 2022 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Retinoic acid reduces cell damage from oxidative stress.

Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

research Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase

5 citations , July 2021 in “Endocrinology, diabetes & metabolism”

Glioblastoma cells can make androgens, which might help the tumor grow.

research 778 Designing and utilizing a c-Rel specific bioassay in drug repurposing screen for HNSCC

July 2024 in “Journal of Investigative Dermatology”

A new test helps find drugs to treat head and neck cancer by targeting c-Rel.

research 268 Use of ultra-fast one-step CK5 ihc for identifying bcc and scc during mohs surgery

1 citations , April 2017 in “Journal of Investigative Dermatology”

A new one-step test can quickly identify skin cancer during surgery.

Immunofluorescence Tomography: High-Resolution 3D Reconstruction by Serial-Sectioning of Methacrylate Embedded Tissues and Alignment of 2D Immunofluorescence Images

research Immunofluorescence Tomography: High-resolution 3-D reconstruction by serial-sectioning of methacrylate embedded tissues and alignment of 2-D immunofluorescence images

8 citations , February 2019 in “Scientific Reports”

Immunofluorescence tomography is a cost-effective method for creating detailed 3-D images of tissues.

research Further Immunocytochemical Characterization of Cultured Hair Apparatus Cells

March 1995 in “The Journal of Dermatology”

Immature hair cells can grow and change into different types of hair cells over time.

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations , July 2019 in “International Journal of Molecular Sciences”

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

research CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations

6 citations , August 2016 in “Journal of Visualized Experiments”

The CUBIC protocol allows detailed 3D visualization of proteins in mouse skin biopsies.

research A Fluorescence-based Lymphocyte Assay Suitable for High-throughput Screening of Small Molecules

9 citations , March 2017 in “Journal of Visualized Experiments”

The assay effectively identifies compounds that affect immune cell activation.

25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

research 25 Hydroxyvitamin D 1 α-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

140 citations , April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.

research Intracrinology and The Skin

82 citations , January 2000 in “Hormone Research in Paediatrics”

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

Promotion of Hair Follicle Development and Trichogenesis by Wnt-10b in Cultured Embryonic Skin and Reconstituted Skin

research Promotion of hair follicle development and trichogenesis by Wnt-10b in cultured embryonic skin and in reconstituted skin

27 citations , May 2006 in “Biochemical and Biophysical Research Communications”

Wnt-10b is important for starting hair growth and developing hair follicles.

research Bulge cells of human hair follicles: segregation, cultivation and properties

27 citations , January 2006 in “Colloids and Surfaces B: Biointerfaces”

Researchers found that bulge cells from human hair can grow quickly in culture and have properties of hair follicle stem cells, which could be useful for skin treatments.

Combination of Media, Biomaterials, and Extracellular Matrix Proteins to Enhance the Differentiation of Neural Stem/Precursor Cells into Neurons

research Combination of media, biomaterials and extracellular matrix proteins to enhance the differentiation of neural stem/precursor cells into neurons

25 citations , April 2012 in “Acta Biomaterialia”

Using certain small proteins with a growth factor and specific materials can increase the creation of neurons from stem cells.