research Diverse Role of OX40 on T Cells as a Therapeutic Target for Skin Diseases
OX40-targeted therapies may help treat skin diseases by reducing inflammation and balancing immune responses.
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research No evidence for the immunocompetence handicap hypothesis in male humans
Higher free testosterone levels in men are linked to a stronger immune response, not weaker.
research Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis
Skin cells control immune cell placement, helping the skin respond better to challenges.
research Treatment of Alopecia Areata with Anti-Interferon-γ Antibodies
Blocking interferon-gamma helps prevent and treat hair loss in Alopecia Areata.
research Epidermal growth factor receptor/mitogen-activated kinase inhibitor treatment induces a distinct inflammatory hair follicle response that includes collapse of immune privilege
EGFRi/MEKi treatments cause hair follicles to lose some immune protection, leading to inflammation.
research Hair care: Stem cells control immune response during wound repair
Stem cells help control the immune response to improve wound healing.
research Expression of Hypothalamic–Pituitary–Thyroid Axis RelatedGenes in the Human Skin
Thyroid-related genes are active in skin cells and may affect autoimmune conditions.
research Dermatologic Care of the Transplant Patient
Transplant patients on immunosuppressive medications have a higher risk of skin cancer, and managing this involves balancing medication with cancer risk.
research Immunological aspects of psychodermatology
The skin plays a key role in immune responses and reflects emotional and stress reactions.
research Epidermal γδ T cells, CD8 T cells and macrophages are increased in number in alopecia areata and express BST2 as part of an interferon-driven antiviral gene signature
In alopecia areata, certain immune cells increase and express a protein linked to immune activation.
research Author response: Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata
ILC1-like cells may contribute to hair loss in alopecia areata.
research Alopecia Areata and Atopic Dermatitis: Common Mechanisms and Emerging Therapeutics
Alopecia areata and atopic dermatitis share immune system issues, and treatments like JAK inhibitors can help both.
research The influence of interferon on healthy and diseased skin
Type I interferons play a key role in the development of various skin diseases.
research Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege
The nail matrix has a reduced immune response, protecting it from autoimmunity.
research 1349 Stimulation of hair follicle stem cell proliferation through an IL-1α dependent activation of γδT-cells
Certain immune cells, when activated by specific signals, can encourage hair growth.
research scRNA+TCR-seq Reveals the Proportion and Characteristics of Dual TCR Treg Cells in Mouse Lymphoid and Non-lymphoid Tissues
Dual TCR Treg cells are common in mouse tissues and vary by location.
research The protective role of FTY720 in promoting survival of allograft fat in mice
FTY720 helps transplanted fat survive better by reducing immune rejection and improving blood vessel growth.
research The role of skin macrophages under conditions of stress and injury: ultraviolet irradiation and wound healing
Inhibiting IL-17 and IL-23 improves wound healing in obese, diabetic mice by promoting healing macrophages.
research CD8-positive Lymphocytes in Graft-Versus-Host Disease of Humanized NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ Mice
CD8+ T cells play a key role in graft-versus-host disease in certain mice models.
research Maintenance of Barrier Tissue Integrity by Unconventional Lymphocytes
Unconventional lymphocytes are important for quick immune responses and healing of skin and mucosal barriers.
research Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.
research 516 Possible role of ILC1 in the pathogenesis of alopecia areata (AA)
ILC1 cells contribute to hair loss in alopecia areata.
research Composite biomaterials in immunomodulation: A new era in targeted therapy
Composite biomaterials can precisely control immune responses for better disease treatment.
research Understanding autoimmunity of vitiligo and alopecia areata
Both vitiligo and alopecia areata involve an immune response triggered by stress and specific genes, with treatments targeting this pathway showing potential.
research Unconventional haircare
Certain immune cells help hair growth by regulating iron in the skin.
research 396 Vδ1 + T-cells are stress-sentinels in human skin and are implicated in alopecia areata pathogenesis
Vδ1+ T-cells in the skin contribute to hair loss in alopecia areata and could be targeted for treatment.
research Supplementary Material for: Plasma proteome–driven identification of druggable immune regulators of alopecia areata, validated by transcriptome and single-cell mapping
CD28 is a promising target for treating alopecia areata with belatacept.
research Supplementary Material for: Plasma proteome–driven identification of druggable immune regulators of alopecia areata, validated by transcriptome and single-cell mapping
CD28 is a promising target for treating alopecia areata with belatacept.
research Macrophages as central mediators of sympathetic neuro-immune interplay in autoimmunity
Restoring nerve-macrophage communication may help treat autoimmune diseases.
research JAK-STAT pathway-associated skin diseases: a refined functional framework for inflammatory skin diseases
The JAK-STAT signaling pathway plays a crucial role in the development of various inflammatory and autoimmune skin diseases, including atopic dermatitis, psoriasis, alopecia areata, and vitiligo. Small molecule JAK inhibitors have shown significant effectiveness in treating these conditions, with specific drugs like abrocitinib, upadacitinib, and baricitinib already approved for certain diseases. The traditional classification of inflammatory skin diseases based on the T helper immune axis is inadequate for distinguishing cytokine signals reliant on the JAK-STAT pathway, limiting its use in targeted therapy. The article proposes a refined framework that incorporates JAK-dependent cytokine modules into the existing Th immune axis system, enhancing the understanding and clinical application of JAK inhibitors for better diagnosis and treatment of skin diseases.