research Janus kinase inhibitors in dermatology: A systematic review
JAK inhibitors help with skin conditions but need more research on dosing and safety.
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research Methotrexate in dermatology
Methotrexate is a key, cost-effective drug for skin conditions, but requires careful monitoring for side effects.
research An Overview of Alopecias
The document explains different types of hair loss, their causes, and treatments, and suggests future research areas.
research Azathioprine
Azathioprine's effectiveness and safety require careful monitoring and more research, especially regarding its use with corticosteroids and the role of TPMT status in patients.
research Tacrolimus in Dermatology
Tacrolimus is effective for various skin conditions with fewer side effects than cyclosporine.
research Decreased CD19+CD24hiCD38hi Regulatory B Cells in Alopecia Areata
Alopecia areata patients have fewer protective regulatory B cells, which may contribute to the disease.
research Immune privilege and alopecia areata
Restoring immune privilege in hair follicles could help treat certain types of hair loss.
research Tacrolimus in Dermatology
Tacrolimus is an effective treatment for several skin conditions with fewer side effects than cyclosporine.
research Pharmacotherapy of alopecia areata
JAK inhibitors and combination therapies show promise for treating severe alopecia areata.
research Jagged-1+ Skin Tregs Modulate the Innate Immune Response to Wound Healing
Jagged-1 in skin Tregs is crucial for timely wound healing by recruiting specific immune cells.
research Editors' Picks
Collagen VII helps skin heal and stay strong, sirolimus may lower skin cancer risk in kidney transplant patients, high-molecular-mass hyaluronan helps naked mole rats resist cancer, dermal γδ T cells aid in hair growth in rodents, and overexpression of IL-33 in mouse skin causes itchiness, offering a model for studying allergic inflammation treatments.
research The pharmacology of methotrexate
Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.
research Autoimmune Skin Disorders
The document concludes that autoimmune skin disorders are treated with corticosteroids and immunosuppressive drugs.
research Successful in situ 5-aminolevulinic acid photodynamic therapy in a 53-year-old female with cutaneous squamous cell carcinoma
Photodynamic therapy successfully treated skin cancer in a 53-year-old woman.
research The expanding impact of T-regs in the skin
T-regulatory cells are important for skin health and can affect hair growth and reduce skin inflammation.
research Dermatologic Changes Associated With Interleukin 2 Administration
IL-2 treatment causes skin eruptions and other reversible side effects, and may play a role in psoriasis.
research Understanding autoimmunity of vitiligo and alopecia areata
Both vitiligo and alopecia areata involve an immune response triggered by stress and specific genes, with treatments targeting this pathway showing potential.
research The role of lymphocytes in the development and treatment of alopecia areata
Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.
research Cystoid macular oedema in uveitis: An unsolved problem
Treating cystoid macular oedema in uveitis is difficult and risky.
research CLINICAL AND LABORATORY EVALUATION OF AIDS TRICHOPATHY
People with HIV and low T cell counts have more hair and scalp problems.
research Effects of cyclosporine A on clinical and histologic abnormalities in dogs with sebaceous adenitis
Cyclosporine A can reduce inflammation in dogs with sebaceous adenitis, but ongoing treatment is needed.
research CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment
CD80 on skin stem cells helps expand Treg cells to aid wound healing.
research Eavesdropping on the conversation between immune cells and the skin epithelium
Immune cells help keep skin healthy and repair it, but imbalance can cause disease.
research Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation
Cells from the lower part of hair follicles are a promising, less invasive option for immune system therapies.
research Hair(y) Matters in Melanoma Biology
The document concludes that the immune-inhibitory environment of the hair follicle may prevent melanoma development.
research Selective Expansion of Tregs Using the IL-2 Cytokine Antibody Complex Does Not Reverse Established Alopecia Areata in C3H/HeJ Mice
Increasing Treg cells in the skin does not cure hair loss from alopecia areata in mice.
research 691 Topical curcumin promotes induction of the murine hair cycle
Curcumin applied to the skin can start hair growth in mice.
research Janus Kinase Inhibitors in the Treatment of Alopecia Areata
JAK inhibitors, like baricitinib, are effective and safe for treating alopecia areata.
research Immune niches for hair follicle development and homeostasis
Immune cells are crucial for hair growth and preventing hair loss.
research Lichen planus – A refractory autoimmune disorder
Lichen planus is a chronic autoimmune disease that is hard to treat and more common in women.