research Modulating the Antioxidant Response for Better Oxidative Stress-Inducing Therapies: How to Take Advantage of Two Sides of the Same Medal?
Enhancing antioxidant responses can improve treatments for various diseases.
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990-1000 / 1000+ resultsresearch Preliminary study on microR-148a and microR-10a in dermal papilla cells of Hu sheep
miR-148a and miR-10a affect hair growth in Hu sheep.
research CXXC5: A novel regulator and coordinator of TGF-β, BMP and Wnt signaling
CXXC5 is a protein that controls cell growth and healing processes, and changes in its activity can lead to diseases like cancer and hair loss.
research Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin
Prostasin has two roles in skin: one for normal skin development without needing activation, and another for proper hair growth that requires activation.
research Partial Purification and Characterization of Two Distinct Types of Caspases from Human Epidermis
Two distinct caspases in human skin help with cell death and skin formation.
research The role of WNT10B in physiology and disease: A 10-year update
WNT10B is important for body functions and linked to diseases like osteoporosis, obesity, and cancer.
research The Human Innate Immune Protein Calprotectin Elicits a Multimetal Starvation Response in Pseudomonas aeruginosa
The study examined the effects of the human innate immune protein calprotectin (CP) on Pseudomonas aeruginosa, focusing on its ability to induce a multimetal starvation response by sequestering essential metals such as iron (Fe), zinc (Zn), and manganese (Mn). CP treatment led to a robust Zn starvation response, characterized by the upregulation of Zn uptake systems, while the Fe response was incomplete. Despite CP's ability to sequester Mn, no significant Mn starvation response was observed. The study also found that CP treatment increased the expression of membrane-remodeling proteins, enhancing tolerance to polymyxin B, an antimicrobial peptide. These responses were distinct from those observed under single-metal limitations, suggesting that CP's multimetal withholding elicits a complex microbial response that affects P. aeruginosa's virulence potential. The research highlighted the intricate relationship between metal homeostasis and pathogen virulence.
research Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament
Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.
research Keratinocyte-Specific Onset of Serine Protease BSSP Expression in Experimental Carcinogenesis
BSSP may help skin tumors grow and could be a marker or target for skin cancer treatment.
research Mechanisms of ivermectin-induced wound healing
Ivermectin cream speeds up wound healing and reduces scarring.