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Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models

research Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

38 citations , June 2018 in “Archives of Toxicology”

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

research Endogenous human skin equivalent promotes in vitro morphogenesis of follicle-like structures

36 citations , May 2016 in “Biomaterials”

Endo-HSE helps grow hair-like structures from human skin cells in the lab.

research Skin organoids: A new human model for developmental and translational research

31 citations , January 2021 in “Experimental Dermatology”

Skin organoids are a promising new model for studying human skin development and testing treatments.

Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

research Review of Hair Follicle Dermal Papilla cells as in vitro</i> screening model for hair growth

76 citations , August 2018 in “International Journal of Cosmetic Science”

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

research Penetration and distribution of three lipophilic probes in vitro in human skin focusing on the hair follicle
54 citations , October 2002 in “Journal of controlled release”

Medium lipophilic substances penetrate skin best, and adding ethanol can increase delivery to hair follicles.

research Effects of non-ablative fractional erbium glass laser treatment on gene regulation in human three-dimensional skin models
24 citations , January 2016 in “Lasers in Medical Science”

Erbium glass laser treatment may help with skin remodeling, reduce inflammation, and improve skin cell maturation.

research Permeation of topically applied caffeine through human skin – a comparison of in vivo and in vitro</i> data
82 citations , May 2009 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

Caffeine penetrates human skin in lab tests similarly to real-life conditions, but actual skin use is still essential for accurate results.

research JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia
8 citations , November 2024 in “EMBO Molecular Medicine”

Targeting JAK-STAT1 can reduce inflammation and promote hair growth in conditions linked to EGFR deficiency.

research Pigment epithelium‑derived factor short peptides facilitate full‑thickness cutaneous wound healing by promoting epithelial basal cell and hair follicle stem cell proliferation
6 citations , September 2017 in “Experimental and Therapeutic Medicine”

Shortened PEDF peptides speed up skin wound healing by boosting cell growth.

research Neonatal murine skin-derived cells transplanted using a mini-chamber model produce robust and normal hair
9 citations , August 2013 in “Journal of Tissue Engineering and Regenerative Medicine”

Transplanted baby mouse skin cells grew normal hair using a new, efficient method.

research Establishing a robust preclinical model to investigate early and late radiation-induced skin reactions
February 2026 in “Scientific Reports”

The model effectively mimics radiation-induced skin damage for future research.

research Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice
86 citations , March 2018 in “ACS Biomaterials Science & Engineering”

MDP hydrogel heals wounds faster and better than other treatments in diabetic mice.

research Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum copticum (L.) Link Seeds
August 2018

Ajwain seed extract improved skin healing and hair growth in a mouse skin irritation model.

research Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury
19 citations , February 2017 in “Journal of radiation research”

High-dose radiation speeds up aging in skin stem cells.

research Clinical efficacy of silk sericin dressing with collagen for split-thickness skin graft donor site treatment
January 2021

Silk sericin dressing with collagen heals wounds faster and improves scar quality better than Bactigras.

research Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In vitro Human Skin Studies
35 citations , January 2018 in “Skin pharmacology and physiology”

Nanoemulsion creams with certain enhancers can greatly increase caffeine delivery through skin.

research Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro
55 citations , June 2009 in “Journal of Pharmaceutical Sciences”

Minoxidil promotes hair growth by penetrating skin, with ethanol-containing formulas working best.

research Effects of Periplaneta americana extracts on the growth and proliferation of cutaneous interstitial cells in cutaneous-wound healing
9 citations , August 2022 in “Frontiers in Pharmacology”

Kangfuxin (KFX) extract speeds up wound healing and improves skin regeneration.

research Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration
August 2024 in “Life Science Alliance”

Helminth protein helps wounds heal better by reducing scarring and promoting tissue growth.

research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With an Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability
17 citations , June 2017 in “Journal of pharmaceutical sciences”

Researchers developed a nanomedicine for acne treatment that delivers medication with less irritation and is non-irritating for oily skin.

research Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and after Transplantation
120 citations , August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

research Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment
July 2024 in “Pharmaceutics”

The new hydrogel treatment promotes faster hair growth and better skin health for hair loss.

research The role of hair follicles and Edar signalling in cutaneous wound healing
January 2016 in “Research Explorer (The University of Manchester)”

Activating the Eda/Edar pathway improves wound healing by enhancing hair follicle growth.

research Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro</i>
37 citations , March 2010 in “British Journal of Dermatology”

Oestrogen and thyrotropin-releasing hormone affect prolactin and its receptor in human skin and hair, suggesting new treatment options for related conditions.

research Hair Dermal papilla maintain its hair inducing characteristics via autocrine exosomal miR-23a-3p
July 2025

Hair growth is maintained by specific cell signals.

research Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

A protein called EGFR protects hair follicle stem cells, and when it's disrupted, hair follicles can be damaged, but blocking certain pathways can restore hair growth.

research In vitro and in vivo evaluation of biologically synthesized silver nanoparticles for topical applications: effect of surface coating and loading into hydrogels
130 citations , January 2017 in “International journal of nanomedicine”

Silver nanoparticles coated with substances like PEG showed strong antibacterial effects and improved wound healing when used in hydrogels.

research 3D-SeboSkin Model for Human ex vivo Studies of Hidradenitis Suppurativa/Acne Inversa
4 citations , June 2021 in “Dermatology”

Scientists created a 3D skin model to study a chronic skin disease and test treatments.

research Hair morphogenesisin vitro</i>: formation of hair structures suitable for implantation
43 citations , August 2008 in “Regenerative Medicine”

Scientists created early-stage hairs from mouse cells that grew into normal, pigmented hair when implanted into other mice.

research Skin Regeneration
January 2016 in “Springer eBooks”

New materials and methods could improve skin healing and reduce scarring.

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Search:

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research Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

research Endogenous human skin equivalent promotes in vitro morphogenesis of follicle-like structures

research Skin organoids: A new human model for developmental and translational research

research Review of Hair Follicle Dermal Papilla cells as in vitro</i> screening model for hair growth

research Penetration and distribution of three lipophilic probes in vitro in human skin focusing on the hair follicle

research Effects of non-ablative fractional erbium glass laser treatment on gene regulation in human three-dimensional skin models

research Permeation of topically applied caffeine through human skin – a comparison of in vivo and in vitro</i> data

research JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia

research Pigment epithelium‑derived factor short peptides facilitate full‑thickness cutaneous wound healing by promoting epithelial basal cell and hair follicle stem cell proliferation

research Neonatal murine skin-derived cells transplanted using a mini-chamber model produce robust and normal hair

research Establishing a robust preclinical model to investigate early and late radiation-induced skin reactions

research Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice

research Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum copticum (L.) Link Seeds

research Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury

research Clinical efficacy of silk sericin dressing with collagen for split-thickness skin graft donor site treatment

research Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In vitro Human Skin Studies

research Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro

research Effects of Periplaneta americana extracts on the growth and proliferation of cutaneous interstitial cells in cutaneous-wound healing

research Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration

research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With an Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

research Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and after Transplantation

research Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment

research The role of hair follicles and Edar signalling in cutaneous wound healing

research Thyrotropin-releasing hormone and oestrogen differentially regulate prolactin and prolactin receptor expression in female human skin and hair follicles in vitro</i>

research Hair Dermal papilla maintain its hair inducing characteristics via autocrine exosomal miR-23a-3p

research Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege

research In vitro and in vivo evaluation of biologically synthesized silver nanoparticles for topical applications: effect of surface coating and loading into hydrogels

research 3D-SeboSkin Model for Human ex vivo Studies of Hidradenitis Suppurativa/Acne Inversa

research Hair morphogenesisin vitro</i>: formation of hair structures suitable for implantation

research Skin Regeneration