research In Situ Self-Assembling Liver Spheroids with Synthetic Nanoscaffolds for Preclinical Drug Screening Applications
PCL nanoscaffold-based liver spheroids are effective for drug screening and studying liver toxicity.
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180-210 / 1000+ resultsresearch New hyaluronan-based biomatrix for 3-D follicle culture yields functionally competent oocytes
A new hyaluronan-based biomatrix successfully supports the growth of mouse ovarian follicles, producing healthy eggs.
research Comparative analysis of 3D and 2D cell-culturing methods in hair follicle spheroid morphogenesis and drug responsiveness
3D cultures respond better to minoxidil, while 2D cultures respond better to DHT.
research Innovative strategies for the discovery of new drugs against androgenetic alopecia
New drug strategies are needed for better hair loss treatments.
research Microfluidic Technology for the Generation of Cell Spheroids and Their Applications
Microfluidic technology improves cell spheroid creation for better drug testing and tissue engineering.
research Metabolic Teamwork in the Stem Cell Niche
Paneth cells and intestinal stem cells work together metabolically for stem cell function and regeneration.
research Effects of Periplaneta americana extracts on the growth and proliferation of cutaneous interstitial cells in cutaneous-wound healing
Kangfuxin (KFX) extract speeds up wound healing and improves skin regeneration.
research A Chemically Defined Culture for Tooth Reconstitution
A new culture system can grow tooth-like structures from dental cells but can't yet develop roots.
research RSPO1, a potent inducer of pancreatic β cell neogenesis
RSPO1 could help create new diabetes treatments by increasing pancreatic β cells.
research Author response: Generation of inner ear hair cells by direct lineage conversion of primary somatic cells
Four transcription factors can convert mouse cells into hair cell-like cells, aiding hearing loss research and treatment.
research Stem cell niche: from concept to reality
Stem cell niches are crucial for maintaining stem cells, with Paneth cells and TGF-beta playing key roles.
research High-Throughput 3D Spheroid Production with Photocurable Polyurethane Microwell Arrays via LCD 3D Printing
The method effectively creates uniform, viable cell spheroids for 3D cell culture.
research Overcoming Curcumin's Limitations: Synthetic Derivatives in Diabetes and Cancer Management
Synthetic curcumin derivatives improve treatment for diabetes and cancer.
research Study of thin films and nanoparticles obtained by self-assembly of block copolymers and their interactions with an oligo / polysaccharide
The research found that nanoparticles coated with chitosan improved the skin penetration of the drug finasteride.
research Tracking adult stem cells
A combined approach is needed to fully understand adult stem cells, with genetic lineage-tracing being crucial.
research Fabrication of Bilayer Nanofibrous-Hydrogel Scaffold from Bacterial Cellulose, PVA, and Gelatin as Advanced Dressing for Wound Healing and Soft Tissue Engineering
The scaffold is a promising material for wound healing and tissue engineering.
research A review for cell-based screening methods in drug discovery
Cell-based screening methods are useful and cost-effective for drug discovery but have pros and cons.
research Advances in single-cell transcriptomics in animal research
Single-cell transcriptomics helps improve animal health and productivity by studying gene expression in individual cells.
research Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19
A standardized drug development platform is essential for efficient and effective drug repurposing, especially during pandemics.
research Advances in 3D printing for the repair of tympanic membrane perforation: a comprehensive review
3D printing shows promise for repairing eardrum perforations but needs more research on materials.
research Antiandrogens as Therapies for COVID-19: A Systematic Review
Antiandrogens don't help with COVID-19 and aren't recommended.
research Volume imaging to interrogate cancer cell-tumor microenvironment interactions in space and time
Advanced imaging methods have improved understanding of cancer cell interactions and treatment strategies.
research Prediction of cell states and key transcription factors of the human cornea through integrated single-cell omics analyses
A new tool accurately identifies human cornea cell states and key factors.
research Exosomal miRNA-218–5p derived from low-passage dermal papilla cells modulates hair follicle growth and development
Exosomal miRNA-218-5p promotes hair growth and development.
research Effects of oxytocin on the hair growth ability of dermal papilla cells
Oxytocin may help hair grow by increasing hair growth-related genes and factors.
research Mice Engrafted with Human Fetal Thymic Tissue and Hematopoietic Stem Cells Develop Pathology Resembling Chronic Graft-versus-Host Disease
Mice with human fetal thymic tissue and stem cells developed symptoms similar to chronic graft-versus-host disease.
research ISX-9 Promotes KGF Secretion From MSCs to Alleviate ALI Through NGFR-ERK-TAU-β-Catenin Signaling Axis
ISX-9 helps stem cells heal lung injury better by boosting growth factor secretion.
research Natural Compounds Targeting MAPK, PI3K/Akt, and JAK/STAT Signaling in Papillary Thyroid Cancer
Natural compounds may help treat advanced papillary thyroid cancer by targeting specific molecular pathways.
research Poly-D,L-Lactic Acid Filler Restores Hair Thickness and Shine by Ameliorating Age-Associated Follicular Decline
PDLLA filler can improve hair thickness and shine by reducing age-related hair decline.
research Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing
Leucocyte-rich platelet-rich plasma boosts cell activity and helps wound healing.