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GlossaryIn Vivo Studies

experiments conducted within living organisms

In vivo studies refer to experiments conducted within a living organism, such as a human, animal, or plant. These studies are crucial for understanding biological processes in their natural context, allowing researchers to observe the effects of treatments, drugs, or genetic modifications in a complex, real-life environment.

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Application of Validated UV Spectrophotometric and Colorimetric Method to Quantify Minoxidil in the Development of Trilayer Dissolving Microneedle: Proof of Concept in Ex Vivo and In Vivo Studies in Rats

research Application of validated UV spectrophotometric and colorimetric method to quantify minoxidil in the development of trilayer dissolving microneedle: Proof of concept in ex vivo and in vivo studies in rats

December 2023 in “Annales Pharmaceutiques Françaises”

The UV–Vis Spectrophotometry method effectively measures minoxidil in rat skin for alopecia treatment.

research In-vivo studies to determine Hair Growth Potential of Poly Herbal Medicated Hair Oil in Female Swiss Albino Mice

March 2023 in “Research journal of pharmacy and technology”

The herbal hair oil helped hair grow in mice.

Development and Ex-Vivo Skin Permeation Studies of Finasteride–Poly(Lactic Acid-Co-Glycolic Acid) and Minoxidil–Chitosan Nanoparticulate Systems

research Development and ex-vivo skin permeation studies of finasteride–poly(lactic acid-co-glycolic acid) and minoxidil–chitosan nanoparticulate systems

12 citations , March 2020 in “Journal of Bioactive and Compatible Polymers”

Nanoparticles show potential for controlled release of hair loss drugs, improving treatment effectiveness.

research In vivo and in vitro studies of anti-aging properties of Dendrobium sabin flower

November 2016 in “Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)”

Dendrobium sabin flower extract may help reduce skin aging from UV exposure.

research New multi-targeting strategy in hair growth promotion: in vitro and in vivo studies

3 citations , May 2018 in “Italian journal of dermatology and venereology”

The lotion with N1-methylspermidine and Sandalore® effectively reduces hair loss and promotes hair growth.

research 593 Low versus high fluence light-induced hair removal: How hair follicle ex vivo studies translate into clinical results

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Higher fluence in hair removal damages hair follicles more, while lower fluence mimics natural hair regression, with long-term IPL treatments effectively reducing hair.

research 3D-SeboSkin Model for Human ex vivo Studies of Hidradenitis Suppurativa/Acne Inversa

4 citations , June 2021 in “Dermatology”

Scientists created a 3D skin model to study a chronic skin disease and test treatments.

Anti-Alopecia Activity of Alkaloids from Noni Fruit Against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In Silico Studies

research Anti-Alopecia Activity of Alkaloids Group from Noni Fruit against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In Silico Studies

1 citations , December 2022 in “Pharmaceuticals”

Noni fruit extract, specifically the FEA-3 sub-fraction, can increase hair growth and reduce baldness in male rabbits, potentially acting like common hair loss treatments.

research A topical product for the loss of volume due to hair ageing: Results of in vivo and ex vivo studies

August 2019 in “Journal of the American Academy of Dermatology”

The product effectively improves hair volume in aging individuals.

research Differences in activity of minoxidil and cyclosporin A on hair growth in nude and normal mice. Comparisons of in vivo and in vitro studies.

35 citations , January 1990 in “PubMed”

Cyclosporin A boosts hair growth in nude mice, but minoxidil does not.

research Topical delivery of meropenem via spanlastic carbopol gel: in-vitro studies and in-vivo application in pressure ulcers

September 2025 in “Frontiers in Pharmacology”

The gel shows strong potential for effectively treating pressure ulcers.

research Anti-cancer properties of olive oil secoiridoid phenols: a systematic review of in vivo studies

104 citations , January 2016 in “Food & Function”

Olive oil compounds may help prevent cancer in animals, but human results are mixed.

research Investigation of Wrightia tinctoria extract activity on Alopecia using In-silco and In-vivo studies

1 citations , February 2022 in “Research journal of pharmacy and technology”

Wrightia tinctoria extract may promote hair growth better than minoxidil.

Recent Developments in Luteolin-Loaded Nanoformulations for Enhanced Anti-Carcinogenic Activities: Insights from In Vitro and In Vivo Studies

research Recent Developments in Luteolin-Loaded Nanoformulations for Enhanced Anti-Carcinogenic Activities: Insights from In Vitro and In Vivo Studies

October 2024 in “Sci”

Nanoformulations improve luteolin's effectiveness as a cancer treatment.

research Recent developments in luteolin-loaded nanoformulations for enhanced anti-carcinogenic activities: insights from in vitro and in vivo studies

January 2024 in “Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)”

Luteolin-loaded nanoformulations could improve cancer treatment by enhancing luteolin's effectiveness.

research Preparation, Optimization, In vitro Evaluation and Ex vivo Permeation Studies of Finasteride loaded gel Formulations Prepared by using Response SurfaceMethodology

3 citations , September 2018 in “Current Drug Delivery”

The combination of propylene glycol and Tween® 80 improves finasteride gel effectiveness.

Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-Loaded Nano Lipidic Carriers-Infused Topical Gel - In Vitro and In Vivo Skin Permeation Studies

research Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-loaded Nano Lipidic Carriers-infused Topical Gel - In vitro and In vivo Skin Permeation Studies

February 2024 in “International journal of pharmaceutical sciences and nanotechnology”

Nanocarriers in gel may reduce side effects of oral hair loss treatments.

research Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-loaded Nano Lipidic Carriers-infused Topical Gel - In vitro and In vivo Skin Permeation Studies

November 2023

The new gel with Zinc Oxide nanoparticles and finasteride shows promise for treating hair loss when applied to the skin.

Drug Repositioning Approach to Target Viral and Host Cells for COVID-19 Treatment: A Review of In Vivo Experiments and Clinical Studies

research Drug repositioning approach to target ‎viral and host cells in terms of COVID-19 treatment: A review of ‎in vivo experiments and clinical studies

October 2022 in “Journal of experimental and clinical medicine”

Repurposing existing drugs for COVID-19 shows promise but requires more research to confirm effectiveness.

research Pectin Nanoparticle-Loaded Soft Coral Nephthea sp. Extract as In Situ Gel Enhances Chronic Wound Healing: In Vitro, In Vivo, and In Silico Studies

10 citations , July 2023 in “Pharmaceuticals”

The gel with coral extract and pectin nanoparticles helps heal chronic wounds.

research Hydroxychloroquine modulates the progression of experimentally induced benign prostatic hyperplasia in rats via targeting EGFR/ERK/STAT3 and AR/FOXO1/TRAIL pathways: computational and in vivo studies

1 citations , June 2025 in “Scientific Reports”

Hydroxychloroquine may help treat benign prostatic hyperplasia by reducing inflammation and promoting cell death.

research [Epididymis in an experimental model of DHT deficiency: immunolocalization of ERalpha and ERbeta in rat epididymal epithelial cells. In vivo and in vitro studies].

4 citations , January 2006 in “PubMed”

DHT deficiency may disrupt rat epididymis function by affecting estrogen receptors.

research Hair growth promoting effects of andrographolide from Andrographis paniculata (Burm.f.) Wall. ex Nees : In vitro, in vivo, and molecular docking studies

October 2025 in “Journal of Ethnopharmacology”

Andrographolide from Andrographis paniculata promotes hair growth and could be a natural treatment for hair loss.

research The Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines

11 citations , December 2024 in “Wound Repair and Regeneration”

The WRAHPS Guidelines standardize reporting in wound healing studies to improve research quality and therapy development.

research 614 Humanized mouse model for hair follicle studies

September 2019 in “Journal of Investigative Dermatology”

Researchers successfully used nude mice to study human hair growth, which could help with future hair research.

Self-Microemulsifying Systems of Finasteride with Enhanced Oral Bioavailability: Multivariate Statistical Evaluation, Characterization, Spray-Drying and In Vivo Studies in Human Volunteers

research Self-microemulsifying systems of Finasteride with enhanced oral bioavailability: multivariate statistical evaluation, characterization, spray-drying and in vivo studies in human volunteers

39 citations , November 2015 in “Nanomedicine”

Improved Finasteride delivery for hair loss treatment.

research Roxithromycin-loaded lipid nanoparticles for follicular targeting

35 citations , October 2015 in “International Journal of Pharmaceutics”

Tiny particles carrying roxithromycin can effectively target and deliver the drug to hair follicles without irritation.

research Limitations of human occipital scalp hair follicle organ culture for studying the effects of minoxidil as a hair growth enhancer

30 citations , September 2004 in “Experimental Dermatology”

Scalp hair follicle culture has limits for testing minoxidil's hair growth effects.

research Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases

26 citations , January 2024 in “Gels”

Nanoemulgels could effectively treat skin diseases and may replace or complement current therapies.

research Niosomes as Vesicular Nanocarriers in Cosmetics: Characterisation, Development and Efficacy

14 citations , February 2025 in “Pharmaceutics”

Niosomes improve delivery and effectiveness of cosmetic ingredients.