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research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

research Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts**This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundacao Coordenacao de Aperfeicoa mento de Pessoal de Nivel Superior (CAPES), Universidade de Sao Paulo (Sao Paulo, Brazil).

43 citations , January 1999 in “Endocrinology”

Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.

research Carvone Decreases Melanin Content by Inhibiting Melanoma Cell Proliferation via the Cyclic Adenosine Monophosphate (cAMP) Pathway

12 citations , November 2020 in “Molecules”

Carvone helps treat skin issues by reducing melanin and stopping harmful cell growth.

research 17‐beta estradiol and prednisolone as potential stimulators of hair re‐growth in chemotherapy‐induced human hair follicle damage via ‘dystrophic catagen’ promotion?

June 2008 in “Experimental Dermatology”

17-beta estradiol and prednisolone may help regrow hair damaged by chemotherapy.

research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis

67 citations , September 2001 in “American Journal Of Pathology”

Inhibiting ODC can prevent UV-induced skin cancer.

research ВПЛИВ ІНОЗИТОЛУ НА ЖІНОК ІЗ СИНДРОМОМ ПОЛІКІСТОЗНИХ ЯЄЧНИКІВ ТА ОЖИРІННЯМ: МЕТАБОЛІЧНІ ТА РЕПРОДУКТИВНІ АСПЕКТИ

April 2024 in “Актуальні питання педіатрії акушерства та гінекології”

Inositol improves metabolism, hormone balance, and reproductive health in women with PCOS and obesity.

research Fluorouracil-Induced Reactive Follicular Squamous Cell Carcinoma

1 citations , July 2016 in “Dermatologic surgery”

research Analysis of Dermal Papilla Cell Interactome Using STRING Database to Profile the ex Vivo Hair Growth Inhibition Effect of a Vinca Alkaloid Drug, Colchicine

23 citations , February 2015 in “International Journal of Molecular Sciences”

Colchicine can inhibit hair growth by affecting cell activity and protein expression in hair follicles.

research P33 Quantification of metabolic pathways in human hair follicles and their response to caffeine and N,N-dimethylglycine

January 2026 in “British Journal of Dermatology”

Caffeine and DMG increase calcium influx in hair follicle cells without being toxic.

research In vivo microautoradiography of [3H]1,24(OH)2D3 (tacalcitol) following topical application to normal rats and in vitro metabolism in human keratinocytes

7 citations , April 1996 in “Archives of dermatological research”

Topical tacalcitol can treat psoriasis by acting directly on skin cells.

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin

45 citations , March 1997 in “Journal of Investigative Dermatology”

research 193 Unveiling the role of estradiol in the pathogenesis of female pattern hair loss

August 2016 in “Journal of Investigative Dermatology”

research Novel aldo-keto reductase 1C3 inhibitor affects androgen metabolism but not ovarian function in healthy women: a phase 1 study

8 citations , June 2023 in “European Journal of Endocrinology”

The inhibitor affects androgen metabolism but not ovarian function.

research The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route

3 citations , October 1994 in “Journal of Labelled Compounds and Radiopharmaceuticals”

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

research Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes

9 citations , January 2018 in “Acta dermato-venereologica”

A substance called poly(I:C) increases a protein called carbonic anhydrase II in skin cells, which might help with skin defense and healing.

research Drug-Induced Alopecia

3 citations , January 2015

Epidermal Growth Factor Receptor Mutant T790M-L858R-V948R Inhibitor from Calophyllum Inophyllum L. Leaf as Potential Non-Small Cell Lung Cancer Drugs

research Epidermal growth factor receptor mutant T790M-L858R-V948R inhibitor from Calophyllum inophyllum L. leaf as potential non-small cell lung cancer drugs

April 2024 in “Journal of pharmacy & pharmacognosy research”

A compound from Calophyllum inophyllum L. leaf may help treat non-small cell lung cancer.

research Abstract SS02-02: Chemoprevention: Poised for Success

November 2008 in “Cancer Prevention Research”

Chemoprevention can significantly lower cancer risks and needs more research and collaboration.

research A HISTOCHEMICAL TEST FOR CITRULLINE ADAPTATION OF THE CARBAMIDO DIACETYL REACTION TO HISTOLOGIC SECTIONS WITH POSITIVE RESULTS IN PILOMATRIXOMAS (CALCIFYING EPITHELIOMAS)

20 citations , February 1968 in “Journal of Histochemistry & Cytochemistry”

A new test more accurately detects citrulline in hair follicles and pilomatrixomas.

Does Active Form of Vitamin D3 Prevent Hair Follicles from Radiation Toxicity?

research 635 poster Does active form of vitamin D3 prevent hair follicules from radiation toxicity?

October 2004 in “Radiotherapy and oncology”

Active vitamin D3 might protect hair follicles from radiation damage.

research Virilizing insulinoma

August 2025 in “Endokrynologia Polska”

Evaluating Combined Therapy With Myoinositol and D-Chiro-Inositol in Infertility Management Across PCOS Phenotypes: A Comprehensive Retrospective Data Analysis

research Evaluating combined therapy with myoinositol and D-chiro-inositol in infertility management across PCOS phenotypes: a comprehensive retrospective data analysis

October 2025 in “International Journal of Reproduction Contraception Obstetrics and Gynecology”

The combined therapy improved fertility in women with PCOS, especially in certain types.

research A possible solution for hair loss by inhibiting corticotropin-releasing factor (CRF) receptor from traditional Chinese medicine

4 citations , September 2013 in “Journal of biomolecular structure and dynamics/Journal of biomolecular structure & dynamics”

Caribine from traditional Chinese medicine may help treat hair loss.

Intraethnic Variation in Steroid-5-Alpha-Reductase Polymorphisms in Prostate Cancer Patients: A Potential Factor Implicated in 5-Alpha-Reductase Inhibitor Treatment

research Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment

4 citations , June 2015 in “Journal of Genetics/Journal of genetics”

Genetic differences within ethnic groups may affect prostate cancer treatment effectiveness.

research Synthesis and Evaluation of 2‘-Substituted 4-(4‘-Carboxy- or 4‘-carboxymethylbenzylidene)-N-acylpiperidines: Highly Potent and in Vivo Active Steroid 5α-Reductase Type 2 Inhibitors

22 citations , June 2002 in “Journal of Medicinal Chemistry”

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

Bioactivity Guided Isolation and Characterization of the Phytoconstituents from Tridax Procumbens

research Bioactivity guided isolation and characterization of the phytoconstituents from the Tridax procumbens

9 citations , February 2011 in “Revista Brasileira de Farmacognosia”

Tridax procumbens plant parts boost immune response in mice.

Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2

research Antroquinonol Exerts Immunosuppressive Effect on CD8⁺ T Cell Proliferation and Activation to Resist Depigmentation Induced by H₂O₂

11 citations , January 2017 in “Oxidative medicine and cellular longevity”

Antroquinonol may help prevent skin depigmentation by suppressing certain immune cells.

research Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts

57 citations , April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology”

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

Benzo[c]quinolizin-3-ones Theoretical Investigation: SAR Analysis and Application to Untested Compounds

research Benzo[c]quinolizin-3-ones Theoretical Investigation: SAR Analysis and Application to Nontested Compounds

6 citations , August 2004 in “Journal of Chemical Information and Computer Sciences”

The research found a link between certain molecular features and the biological activity of BC3, which can help identify or create new active compounds.

research Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids

November 2023

New steroid derivatives show promise as anticancer agents, even against resistant cells.

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