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Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

research Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

1 citations , May 2022 in “Frontiers in Pharmacology”

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

research Pharmacological Activation of Thermo–Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

12 citations , June 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

Activating TRPV3 channels stops hair growth by killing hair follicle cells.

research Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata

2 citations , December 2022 in “PNAS nexus”

SCD-153 shows promise as an effective topical treatment for alopecia areata.

research Preparatory work to support the risk assessment for peri‐ and postmenopausal women taking food supplements containing isolated isoflavones

3 citations , October 2015 in “EFSA supporting publications”

Isoflavones may help with menopause symptoms but could be risky for women with hormone-sensitive cancers.

Biosynthetic Studies Through Feeding Experiments in Eclipta Prostrata Hairy Roots

research Biosynthetic studies through feeding experiments in Eclipta prostrata (L.) L. hairy roots

1 citations , July 2022 in “Plant Cell, Tissue and Organ Culture (PCTOC)”

The study found that in Eclipta prostrata roots, coumestans come from acetate and shikimate pathways, and phenylpropanoid is made only through the shikimate pathway.

In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus Spina-Christi

research In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus spina-christi

January 2024 in “Biochemistry Research International”

Compounds from Ziziphus spina-christi roots show strong antibacterial and antioxidant potential.

Progesterone-Induced Stimulation of Mammary Tumorigenesis Is Due to the Progesterone Metabolite, 5α-Dihydroprogesterone (5αP), and Can Be Suppressed by the 5α-Reductase Inhibitor, Finasteride

research Progesterone-induced stimulation of mammary tumorigenesis is due to the progesterone metabolite, 5α-dihydroprogesterone (5αP) and can be suppressed by the 5α-reductase inhibitor, finasteride

21 citations , January 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

research AVALIAÇÃO IN VITRO DO POTENCIAL CITOTÓXICO DOS ÓLEOS DE ALPINIA SPECIOSA, AGERATUM CONYZOIDES E DYSPHANIA AMBROSIOIDES EM LINHAGEM CELULAR DE CÂNCER DE PRÓSTATA, LINFOMA HISTIOCÍTICO E LEUCEMIA MIELOIDE CRÔNICA

January 2017 in “Anais do 5º Encontro Brasileiro para Inovação Terapêutica”

The oils showed potential to kill certain cancer cells, especially from Dysphania ambrosioides.

research Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole

28 citations , September 2021 in “EMBO reports”

Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.

Multicentric Parallel Phase II Trial of the Polo-Like Kinase 1 Inhibitor BI 2536 in Patients With Advanced Head and Neck Cancer, Breast Cancer, Ovarian Cancer, Soft Tissue Sarcoma, and Melanoma. The First Protocol of the European Organization for Research and Treatment of Cancer Network of Core Institutes

research Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research and Treatment of Cancer (EORTC) Network Of Core Institutes (NOCI)

93 citations , May 2010 in “European Journal of Cancer”

BI 2536 had limited effectiveness against several advanced cancers and caused significant side effects.

research Cinnamomum burmannii Leaves-Derived Carbon Dots Promote Angiogenesis and Stimulate Hair Follicle Regeneration by Reshaping the Microenvironment of Hair Follicles

February 2026 in “ACS Applied Materials & Interfaces”

Carbon dots from Cinnamomum burmannii leaves can promote hair growth and regeneration.

research The regenerative wound healing effects and molecular mechanism of Isaria cicadae Miquel rice fermentation extract

2 citations , February 2025 in “Applied Microbiology and Biotechnology”

Isaria cicadae Miquel rice fermentation extract helps heal wounds and regenerate hair follicles.

research Drug-induced postinfantile giant cell hepatitis

10 citations , October 2010 in “Hepatology”

Certain liver diseases respond well to specific treatments and have varying risks for liver cancer.

research Vitamin D3 and chemotherapy-induced alopecia

11 citations , June 1996 in “Nutrition”

Vitamin D3 may prevent hair loss from chemotherapy, but side effects and cancer cell protection are concerns.

research Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt

83 citations , October 2012 in “International Journal of Oncology”

Wedelolactone selectively kills prostate cancer cells without harming normal cells.

research Increased anxiety‐like phenotype in female guinea pigs following reduced neurosteroid exposure in utero

12 citations , February 2017 in “International journal of developmental neuroscience”

Female guinea pigs exposed to less allopregnanolone before birth showed more anxiety-like behavior.

research 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1

13 citations , August 2007 in “Bioorganic & medicinal chemistry letters”

A new compound effectively inhibits human 5α-reductase 1.

research Serum 3α-androstanediol-glucuronide is decreased in nonhirsute women with acne vulgaris

10 citations , December 1996 in “Fertility and Sterility”

Women with acne have lower levels of a specific hormone marker than women without acne.

research Ornithine decarboxylase activity in relation to DNA synthesis in mouse interfollicular epidermis and hair follicles

34 citations , October 1975 in “Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis”

Intraethnic Variation in Steroid-5-Alpha-Reductase Polymorphisms in Prostate Cancer Patients: A Potential Factor Implicated in 5-Alpha-Reductase Inhibitor Treatment

research Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment

4 citations , June 2015 in “Journal of Genetics/Journal of genetics”

Genetic differences within ethnic groups may affect prostate cancer treatment effectiveness.

research New potential chemotherapy for ovarian cancer — Combined therapy with WP 631 and epothilone B

12 citations , March 2016 in “Life Sciences”

The new chemotherapy combination of WP 631 and Epothilone B shows enhanced effectiveness against ovarian cancer but requires more research on its safety.