113 citations
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June 2015 in “Stem Cell Research & Therapy” Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.
59 citations
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April 2016 in “Cell Reports” EdnrB signaling helps melanocyte stem cells regenerate and could be targeted to treat pigmentation issues.
59 citations
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November 2010 in “Circulation Research” Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.
56 citations
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March 2015 in “Cell death and differentiation” Older skin has higher cancer risk due to inflammation and stem cell issues.
51 citations
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March 2014 in “Nature Communications” Skin tumor regression is helped by retinoic acid signaling blocking Wnt signaling.
45 citations
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September 2012 in “Life Sciences” Aconiti Ciliare Tuber extract may help hair grow by activating a specific cell signaling pathway.
40 citations
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April 2014 in “Genes & Development” Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.
28 citations
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January 2018 in “Biochemical Society Transactions” Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.
27 citations
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June 2023 in “Nature” Senescent melanocytes can boost hair growth by activating hair stem cells.
26 citations
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December 2017 in “Journal of Investigative Dermatology” Disrupting Notch signaling in blood vessels increases scarring during wound healing in mice.
26 citations
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October 2016 in “Biomolecules & Therapeutics” 3-Deoxysappanchalcone helps human hair cells grow and stimulates hair growth in mice by affecting certain cell signaling pathways.
25 citations
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September 2018 in “Molecular Biology of the Cell” Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.
23 citations
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November 2024 in “Scientific Reports” Higher thyroid antibodies in Hashimoto's thyroiditis are linked to more inflammation and symptoms.
20 citations
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February 2017 in “International Journal of Dermatology” Honokiol helps protect skin from damage and aging caused by cigarette smoke.
18 citations
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July 2021 in “Molecular Medicine Reports” The WNT signaling pathway is crucial for mesenchymal stem cells' function and therapy success.
18 citations
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November 2020 in “Frontiers in Cell and Developmental Biology” Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.
14 citations
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June 2021 in “Expert Opinion on Therapeutic Patents” New patents show progress in developing drugs targeting the Wnt pathway for diseases like cancer and hair loss.
14 citations
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June 2018 in “Frontiers in pharmacology” Green tea compound EGCG helps mink hair follicles grow by affecting certain cell growth pathways.
6 citations
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January 2016 in “Evidence-based Complementary and Alternative Medicine” Boiling and fermenting certain herbs can help hair grow by activating hair growth genes and pathways.
5 citations
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October 2023 in “Aging” Sonic hedgehog signaling helps heal pressure ulcers by improving blood vessel growth.
2 citations
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November 2019 in “Cancer reports” The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.
1 citations
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March 2024 in “Cellular and Molecular Biology” The "simmer pus and grow flesh" method helps heal chronic wounds in rats.
1 citations
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June 2019 in “Food Research” Tempeh oil rich in linoleic acid may protect against skin aging caused by UV light.
January 2026 in “Frontiers in Bioscience-Landmark” Araliadiol protects skin cells from damage by boosting antioxidant defenses.
October 2025 in “Frontiers in Immunology” Platelet-rich plasma might help treat eczema by reducing inflammation and repairing the skin.
October 2025 in “Clinical Cosmetic and Investigational Dermatology” Targeting specific cell interactions may help treat skin fibrosis.
March 2024 in “Journal of Microbiology and Biotechnology” Phloroglucinol may help improve hair loss by promoting hair growth and reducing oxidative stress.
January 2024 in “Journal of cellular immunology” Hair follicle stem cells are important for maintaining healthy skin and interact with many signals.
September 2023 in “Research Square (Research Square)” TNC+ fibroblasts play a key role in skin inflammation by interacting with T cells.
L-PGDS has specific binding sites for its functions and could help in drug delivery system design.