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GlossaryInflammatory Mediators

substances released to initiate and regulate inflammation

Inflammatory mediators are substances released by immune cells and other tissues in response to injury or infection, which help to initiate and regulate the inflammatory response. These can include cytokines, prostaglandins, and histamines, among others, and they play crucial roles in signaling pathways that lead to symptoms like redness, swelling, and pain. Understanding these mediators is essential for developing treatments for conditions like alopecia, where inflammation can contribute to hair loss.

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research Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways

9 citations , February 2025 in “Journal of Nanobiotechnology”

Biomimetic nanovesicles can speed up diabetic wound healing by regulating immune cell behavior and metabolism.

research New insights into inflammatory memory of epidermal stem cells

2 citations , May 2023 in “Frontiers in immunology”

Skin stem cells remember past inflammation, helping them respond better to future injuries and possibly aiding in treating skin issues.

research Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

245 citations , October 2015 in “Nature medicine”

Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.

Neuroprotective and Immunomodulatory Effects of Human Hair Follicle Stem Cells on Streptozotocin-Induced Memory Impairment in Rats: Insights into Inflammation and Neurotrophic Mechanisms

research Neuroprotective and immunomodulatory effects of human hair follicle stem cells on streptozotocin-induced memory impairment in rats: insights into inflammation and neurotrophic mechanisms

May 2025

Human hair follicle stem cells improved memory and brain health in rats.

research Skin in the Game: Stem Cells in Repair, Cancer, and Homeostasis

2 citations , March 2020 in “Cell”

Elaine Fuchs' research shows how skin stem cells maintain health, aid in healing, and are involved in cancer.

research Autoimmune skin disease pathogenesis: a chronological immune cascade and multi-hit model

January 2026 in “Immunity & Inflammation”

Autoimmune skin diseases result from genetic and environmental factors disrupting immune checkpoints.

research 046 Analysing the mechanistic basis of Ritlecitinib’s therapeutic effects in Alopecia Areata

November 2025 in “Journal of Investigative Dermatology”

Ritlecitinib effectively treats severe Alopecia Areata by reducing harmful immune activity in the skin.

research The Dynamics of the Skin’s Immune System

306 citations , April 2019 in “International Journal of Molecular Sciences”

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

research An Overview on Ethanopharmacological Profile of Bacopa Monniera

March 2025

Bacopa monniera promotes hair growth, enhances memory, and helps with inflammation and stomach issues.

research Physiological and pharmacological features of the non-saponin components in Korean Red Ginseng

67 citations , February 2020 in “Journal of Ginseng Research”

Korean Red Ginseng has beneficial components that help with stress, immunity, fatigue, memory, blood flow, and disease protection.

research In Quest of the Mysterious Holistic Vedic Herb Bacopa monnieri (L.) Pennell

1 citations , June 2023 in “Pharmacognosy Research”

Bacopa monnieri, or Brahmi, is a traditional herb that may improve memory and treat various conditions, but more research is needed.

research 0960 Evidence for resident memory T cells and necroptosis as drivers of fibrosis in eosinophilic fasciitis and morphea

July 2025 in “Journal of Investigative Dermatology”

Resident memory T cells and necroptosis may drive fibrosis in eosinophilic fasciitis and morphea.

research Single-cell sequencing combined with spatial transcriptomics reveals the characteristics of follicle-targeted inflammation patterns in primary cicatricial alopecia

July 2025 in “Cell & Bioscience”

Specific immune cells and pathways contribute to hair follicle inflammation and hair loss, suggesting potential treatments for lichen planopilaris.

research Pathological sequelae of long-haul COVID

353 citations , February 2022 in “Nature Immunology”

Long-haul COVID can cause lasting symptoms affecting many body systems and may be linked to ongoing inflammation and immune system issues.

research Volatile organic compounds: A proinflammatory activator in autoimmune diseases

18 citations , July 2022 in “Frontiers in Immunology”

Volatile organic compounds can cause inflammation and increase the risk of autoimmune diseases.

research Serum sickness–like reaction in children: A retrospective review

1 citations , February 2009 in “Journal of The American Academy of Dermatology”

Children's Serum Sickness-Like Reaction is often linked to antibiotics, especially amoxicillin, and involves symptoms like rash, fever, and joint issues.

research Choreographing Immunity in the Skin Epithelial Barrier

57 citations , March 2019 in “Immunity”

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

research Nutritional and therapeutic importance of Daucus carota- A review

60 citations , June 2017 in “IOSR Journal of Pharmacy (IOSRPHR)”

Carrots are nutritious and offer many health benefits, including antioxidant and anti-inflammatory effects.

research Progress on study of pharmacological effects of procyanidins

1 citations , March 2009 in “China Journal of Chinese Matera Medica”

Procyanidins may have antioxidant, heart health, cancer-fighting, anti-inflammatory, anti-diabetic, liver-protective, and other health benefits with high efficiency and low toxicity.

research IL-15 in T-Cell Responses and Immunopathogenesis

48 citations , January 2024 in “Immune Network”

IL-15 is key for T cell function and could help improve treatments for immune-related diseases.

research Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra

119 citations , June 2021 in “Heliyon”

Licorice has many health benefits but should be used carefully due to possible side effects.

research The Potential of Ginkgo biloba as a Source of Biologically Active Compounds—A Review of the Recent Literature and Patents

70 citations , May 2023 in “Molecules”

Ginkgo biloba has health benefits but also contains toxic compounds, driving interest in its use in medicine and food.

research Immune-Epithelial Cross Talk in Regeneration and Repair

52 citations , January 2023 in “Annual Review of Immunology”

Immune-epithelial interactions are crucial for tissue repair, but unchecked can cause diseases.

research Fibroblasts in Diabetic Foot Ulcers

33 citations , February 2024 in “International Journal of Molecular Sciences”

Understanding fibroblast issues in diabetic foot ulcers is key to creating better treatments.

research Wonders of Leafy Spices: Medicinal Properties Ensuring Human Health

22 citations , September 2013 in “Science international”

Leafy spices like basil and mint are very healthy and can help with digestion, hair loss, and inflammation.

research A REVIEW ON PHYTOPHARMACOLOGICAL SIGNIFICANCE OF ECLIPTA ALBA

1 citations , January 2020 in “International journal of research in pharmacy and chemistry”

Eclipta alba has many health benefits and potential for medical and nutritional use.

research A review on phytochemistry and pharmacology of Eclipta alba L.: A valuable medicinal plant

February 2022 in “Research Journal of Biotechnology”

Eclipta alba L. is a medicinal plant with many health benefits, including treating diseases and promoting hair growth.

research Local heroes or villains: tissue-resident memory T cells in human health and disease

67 citations , January 2020 in “Cellular & Molecular Immunology/Cellular & molecular immunology”

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

research Inflammatory loops in the epithelial–immune microenvironment of the skin and skin appendages in chronic inflammatory diseases

3 citations , September 2023 in “Frontiers in immunology”

Chronic inflammatory skin diseases are caused by disrupted interactions between skin cells and immune cells.

research The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases

70 citations , October 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.