TLDR Immune-epithelial interactions are crucial for tissue repair, but unchecked can cause diseases.
The document explores the critical role of immune-epithelial interactions in tissue regeneration and repair, particularly in the skin and gut. It highlights how immune cells, such as macrophages and regulatory T cells (Tregs), influence hair follicle stem cells (HFSCs) and intestinal stem cells (ISCs) through various signaling pathways, promoting proliferation, differentiation, and maintaining homeostasis. The study emphasizes the importance of immune signals in re-epithelialization and the potential for leveraging these interactions in therapeutic strategies for regenerative medicine and treating epithelial inflammatory diseases. It also discusses the concept of inflammatory memory in epithelial stem cells and its implications for repair functions, suggesting that understanding these interactions could lead to new therapies for inflammatory diseases and enhance regenerative medicine.
488 citations
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July 2021 in “Cell” Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.
124 citations
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June 2020 in “Cell Stem Cell” Fat cells in the skin help start healing and form important repair cells after injury.
101 citations
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March 2019 in “Cell Stem Cell” Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.
45 citations
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August 2018 in “Haematologica” Macrophage iron release is crucial for hair growth and wound healing.
117 citations
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March 2017 in “Nature Communications” Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.
363 citations
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March 2017 in “Nature Communications” 175 citations
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December 2014 in “PLoS Biology” Macrophages help activate hair follicle stem cells, affecting hair growth and skin repair.
426 citations
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August 2014 in “Nature Medicine” Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
286 citations
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June 2012 in “Nature Immunology” Hair follicles help attract immune cells to the skin during stress.
10 citations
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January 2019 in “International Immunology” Immune cells help keep skin healthy and repair it, but imbalance can cause disease.
57 citations
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March 2019 in “Immunity” The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.
9 citations
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April 2021 in “Frontiers in Immunology” Unconventional lymphocytes are important for quick immune responses and healing of skin and mucosal barriers.
8 citations
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January 2022 in “Burns and trauma” Skin cell-derived vesicles can help heal skin injuries effectively.
41 citations
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July 2019 in “Clinical Cosmetic and Investigational Dermatology” The skin's immune system helps it regenerate and fight infections.
