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Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

Certain alkaloids could help create new coronavirus drugs.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

People with PCOS have higher levels of PAI-1, which may increase their risk of heart disease and fertility issues.

New compounds were made that are promising for prostate cancer therapy.

Mitochondrial Complex I reduces inflammation and increases bone breakdown by affecting certain immune cells.

Researchers found several compounds that could potentially treat Zika virus.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction, but the exact reasons are unclear.

Midazolam's seizure prevention is partly due to increased neurosteroid production.

Two existing drugs may help treat COVID-19 by inhibiting a key viral protein.

Researchers identified promising inhibitors for the BRD4 protein, including finasteride and amentoflavone.

The S9 fraction with GC-IDMS is effective for measuring 5α-reductase activity.

5-alpha reductase inhibitors might worsen lung recovery in COVID-19 patients, suggesting a pause in their use.

Testosterone increases acidification in the vas deferens by up-regulating V-ATPase.

Certain drugs like Dutasteride and Finasteride might help fight SARS-CoV-2 by increasing levels of a steroid called DHEA, which can protect the heart and increase nitric oxide to counteract the virus.

New nanoparticles deliver plant extracts to hair follicles to treat conditions like hair loss and acne.

Mefloquine, an antimalarial drug, is effective in killing melanoma cells resistant to other treatments by causing lethal stress in the cells.

5αR inhibitors help slow early prostate cancer cell growth, suggesting combined treatments are needed.

Inhibiting testosterone 5alpha-reductase may help treat benign prostatic hyperplasia.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

Certain substances that block a specific protein help promote hair growth.

Abietic acid from pine resin can effectively inhibit testosterone 5α-reductase.

Changing the 6-position on benzopyran molecules affects insulin release, with some compounds showing strong inhibitory effects.

New indole-based compounds, particularly cemtirestat, show promise as dual-function drugs for diabetic complications.

Metabolite 7 is a strong inhibitor for Alzheimer's disease management.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.

CS-891 may effectively treat hair loss by blocking enzymes in hair follicles.

Shallots may help lower blood sugar, but more research is needed.