November 2025 in “SKIN The Journal of Cutaneous Medicine” Upadacitinib effectively treats severe alopecia areata and is safe.
November 2017 in “Asian journal of pharmaceutical and clinical research” Three compounds from Dadap leaves may help treat hair loss.
50 citations
,
August 1999 in “Experimental dermatology” The control system for hair growth cycles is not well understood and needs more research.
474 citations
,
January 2012 in “Chemistry & biology” Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.
179 citations
,
July 2016 in “Nature Reviews Molecular Cell Biology” Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.
161 citations
,
August 2013 in “Journal of experimental botany” Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.
111 citations
,
August 2002 in “Journal of Medicinal Chemistry” New compounds were made that block an enzyme linked to breast cancer better than existing treatments.
103 citations
,
November 2014 in “Journal of Cell Biology” MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.
81 citations
,
September 2005 in “The American journal of pathology” Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.
51 citations
,
June 2021 in “Signal Transduction and Targeted Therapy” The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.
41 citations
,
November 2013 in “Experimental Dermatology” Leptin, a hormone, is important for starting hair growth.
34 citations
,
August 2011 in “Journal of Natural Medicines” Puerariae Flos extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.
28 citations
,
February 2019 in “Genes” Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.
25 citations
,
November 2015 in “Journal of Ethnopharmacology” Certain Chinese herbs, especially Cacumen platycladi, can promote hair regrowth and reduce hair loss-related hormone levels in mice.
25 citations
,
March 2014 in “Experimental Dermatology” Leptin helps start the growth phase of hair.
22 citations
,
April 2015 in “Current problems in dermatology” Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.
12 citations
,
June 2013 in “The Prostate” Dutasteride and finasteride affect different cell types differently.
8 citations
,
December 2018 in “Journal of Dermatological Treatment” The PRP-like cosmetic with biomimetic peptides is potentially effective and safe for treating alopecia areata.
5 citations
,
January 2021 in “Journal of Cosmetic Dermatology” Topical cetirizine 1% promotes hair growth in male androgenetic alopecia patients.
5 citations
,
November 2016 in “Experimental and Therapeutic Medicine” BeauTop improves hair growth in androgenetic alopecia patients.
5 citations
,
February 1997 in “Bioorganic & Medicinal Chemistry” New compounds were made that effectively block a specific enzyme related to androgen conditions.
2 citations
,
November 2018 in “Indian Journal of Pharmaceutical Education” The developed model can predict effective 5-alpha-reductase enzyme inhibitors.
August 2023 in “Malaysian Journal of Medicine and Health Sciences/Malaysian journal of medicine and health sciences” Pueraria mirifica extract may help treat benign prostatic hyperplasia.
September 2022 in “Research Square (Research Square)” Probiotics and synbiotics may help with PCOS symptoms, but more research is needed.
November 2020 in “Elsevier eBooks” Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.
42 citations
,
November 2018 in “Archives of dermatological research” Apremilast was not effective in treating moderate-to-severe alopecia areata.
180 citations
,
November 1991 in “American Journal of Psychiatry” Fluoxetine was not effective in treating hair-pulling disorder in the short term.
147 citations
,
June 2011 in “New England journal of medicine/The New England journal of medicine” 5α-reductase inhibitors may prevent prostate cancer but could also raise the risk of more severe cancers.
56 citations
,
January 2019 in “Lancet” JAK inhibitors help regrow hair in alopecia areata patients, improving their quality of life.
37 citations
,
January 2009 in “Sexual Development” Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.