153 citations
,
October 2012 in “Skin Pharmacology and Physiology” Caffeine in cosmetics may reduce cellulite, protect skin, and stimulate hair growth, but more research is needed on its use and effects.
35 citations
,
February 2002 in “Journal of Radiological Protection” Caffeine reduces radiation skin damage but doesn't affect tumor treatment.
May 2025 in “International Journal of Innovative Technologies in Social Science” Caffeine causes sleep problems in many medical students.
December 2020 in “Journal of Cosmetic Science” The caffeine content in anticellulite gels is 0.7-1.7% and in hair-care products is about 1.0%.
August 2024 in “Cosmetics” Caffeine is beneficial for skin and hair treatments but needs better delivery methods to penetrate deeper skin layers.
42 citations
,
July 2014 in “European journal of pharmaceutics and biopharmaceutics” Caffeine nanocrystals for skin products stay stable with the right stabilizer, but grow in size at higher temperatures.
1 citations
,
March 2025 in “Biomedical Journal of Scientific & Technical Research” Caffeine can effectively treat hair loss and skin issues.
November 2021 in “Research Square (Research Square)” The new caffeine cream works better for hair growth than existing products.
15 citations
,
October 2020 in “European journal of pharmaceutics and biopharmaceutics” Caffeine penetrates skin quickly through open hair follicles, but less through closed ones, with levels becoming equal after 22 hours.
4 citations
,
February 2022 in “Journal of Pharmaceutical and Biomedical Analysis” The conclusion is that a new method can measure caffeine and drugs in hair, finding caffeine abusers have 70 times more caffeine than normal, with a proposed cut-off value for abuse.
46 citations
,
January 2008 in “Journal of cosmetic dermatology” Caffeine and siloxanetriol alginate caffeine in emulsion form can reduce fatty cell size and number, potentially treating cellulite effectively.
Nanoparticles with caffeine can be used for slow, continuous hair growth stimulation.
61 citations
,
May 2014 in “International journal of pharmaceutics” Nanocrystals improve skin penetration and stability of caffeine, suggesting a new method for delivering similar substances through the skin.
May 2026 in “Jurnal Riset Kefarmasian Indonesia” Robusta coffee beans have high caffeine content, useful for products like hair growth stimulants.
33 citations
,
September 2006 in “International Journal of Cosmetic Science” Caffeine improves male skin's barrier function.
21 citations
,
January 2017 in “Skin Pharmacology and Physiology” Caffeine-based liquid 0.2% is as effective as minoxidil 5% for treating male hair loss.
24 citations
,
February 2007 in “Laser Physics Letters” Caffeine shampoo penetrates hair follicles deeply and stays for up to 48 hours.
October 2025 in “Journal of Drugs in Dermatology” Topical caffeine can help with hair growth and reduce hair loss safely.
4 citations
,
September 1999 in “Journal of Clinical Forensic Medicine” Caffeine in hair might help identify people, but it's not always reliable.
August 2019 in “Journal of the American Academy of Dermatology” Ginseng and Albizia extracts help prevent hair thinning with age.
The optimal concentration for caffeine release in gel form is 0.2% caffeine and 2.3% chitosan.
26 citations
,
December 2009 in “Laser Physics” Caffeine from shampoo penetrates hair follicles quickly and stays for at least 24 hours.
1 citations
,
July 2023 in “Cosmetics” The new shampoo effectively delivers caffeine to hair follicles to help keep hair, especially as people age.
2 citations
,
January 2022 in “Materials today: proceedings” Caffeine may be good for hair growth and skin care because it binds well with keratin.
182 citations
,
December 2007 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Hair follicles significantly increase the speed and amount of caffeine absorbed through the skin.
December 2024 in “PubMed”
May 2026 in “International Journal of Drug Delivery Technology” Adrenaline infiltration improves hair transplant efficiency and safety.
10 citations
,
July 2021 in “European journal of pharmaceutics and biopharmaceutics” Nanoparticles sized between 470 and 750 nm are best for delivering substances like caffeine into hair follicles for absorption.
September 2023 in “Journal of The American Academy of Dermatology” Caffeine may help hair grow better.