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GlossaryInsulin-like Growth Factor Binding Protein 1

regulates insulin-like growth factors' availability and activity in the body

Insulin-like Growth Factor Binding Protein 1 (IGFBP-1) is a protein that binds to insulin-like growth factors (IGFs), which are hormones that play a crucial role in growth and development. By binding to IGFs, IGFBP-1 regulates their availability and activity in the body, influencing processes such as cell growth, differentiation, and metabolism. Elevated levels of IGFBP-1 can be associated with conditions like insulin resistance and metabolic disorders.

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research Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts**This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundacao Coordenacao de Aperfeicoa mento de Pessoal de Nivel Superior (CAPES), Universidade de Sao Paulo (Sao Paulo, Brazil).

43 citations , January 1999 in “Endocrinology”

Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.

Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

research Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

54 citations , November 2017 in “Scientific Reports”

The study found that certain microRNAs are higher in the cells and lower in the fluid of women with a specific type of polycystic ovary syndrome, and one microRNA could potentially help diagnose the condition.

research Skin Deep and Deeper: Multiple Pathways in Basal Cell Carcinogenesis

5 citations , September 2010 in “Cancer Prevention Research”

The research suggests new treatments for skin cancer could target specific cell growth pathways.

research Effects of oxytocin on the hair growth ability of dermal papilla cells

October 2023 in “Scientific Reports”

Oxytocin may help hair grow by increasing hair growth-related genes and factors.

research Involvement of DKK1 secreted from adipose‐derived stem cells in alopecia areata

November 2023 in “Cell Proliferation”

A protein from fat-derived stem cells, DKK1, is linked to hair loss and blocking it may help treat alopecia areata.

research CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata

January 2024 in “International Journal of Molecular Sciences”

Blocking the protein CXCL12 with a specific antibody can increase hair growth in common hair loss conditions.

Hair Thickness Growth Effect of Adenosine Complex in Male and Female Patterned Hair Loss via Inhibition of Androgen Receptor Signaling

research Hair Thickness Growth Effect of Adenosine Complex in Male-/Female-Patterned Hair Loss via Inhibition of Androgen Receptor Signaling

June 2024 in “International journal of molecular sciences”

Adenosine complex helps increase hair thickness and density in hair loss.

research Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome

53 citations , November 2021 in “Molecular Human Reproduction”

N-acetylcysteine may help treat uterine and placental issues in PCOS.

Effects of Glucagon-Like Peptide-1 Receptor Agonists on Skin Homeostasis and Aging Processes

research Effects of Glucagon-like Peptide-1 Receptor Agonists on Skin Homeostasis and Skin Aging Processes

April 2026 in “Journal of Clinical Medicine”

GLP-1 RAs may help wound healing but can also cause faster facial aging and skin issues.

research Polycystic ovary syndrome patients with high BMI tend to have functional disorders of androgen excess: a prospective study

23 citations , January 2016 in “Journal of Nanjing Medical University”

Overweight women with PCOS are more likely to have excess male hormones.

research Polysaccharides from the Sargassum and Brown Algae Genus: Extraction, Purification, and Their Potential Therapeutic Applications

2 citations , June 2023 in “Plants”

Sugars from Sargassum and brown algae may have health benefits like fighting viruses and helping with wound healing, but there are challenges in using them.

research Human Follicular Papilla Cells Carry Out Nonadipose Tissue Production of Leptin

37 citations , December 2001 in “Journal of Investigative Dermatology”

Leptin may play a role in hair growth and hair follicle health.

research Anabolic androgenic steroids and carcinogenicity focusing on Leydig cell: a literature review

65 citations , April 2018 in “Oncotarget”

Anabolic androgenic steroids can increase cancer risk and disrupt hormones.

Minoxidil Prevents MDMA-Induced Serotonin Depletions: Role of Mitochondrial ATP-Sensitive Potassium Channels, Akt, and ERK

research Minoxidil prevents 3,4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK

22 citations , February 2008 in “Journal of Neurochemistry”

Minoxidil prevents serotonin loss from MDMA by affecting potassium channels and increasing Akt phosphorylation.

research Industry update: the latest developments in the field of therapeutic delivery, July 2018

1 citations , November 2018 in “Therapeutic Delivery”

New partnerships, clinical trials, and drug approvals marked progress in therapeutic delivery in July 2018.

Guava Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

research Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

7 citations , December 2022 in “Plants”

Guava leaf extract may help treat hair loss and protect cells by blocking certain genes and fighting damaging molecules.

research Dermo-Cosmetic Benefits of Marine Macroalgae-Derived Phenolic Compounds

9 citations , November 2022 in “Applied sciences”

Marine algae compounds may improve skin health and promote hair growth.

research Green tea: Health benefits

86 citations , January 2008 in “Journal of nutritional & environmental medicine”

Green tea may help with health issues like cancer, heart disease, and weight loss due to its high catechin content.

research Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway

March 2023 in “International Journal of Molecular Sciences”

ADSC-Exos with miR-122-5p can help treat hair loss by promoting hair growth.

research Alopecia and Thyroid Disease

January 2008 in “Springer eBooks”

Thyroid disease can cause hair loss and treating thyroid problems might help with hair disorders.

research Hair growth-promoting effects of Sargassum glaucescens oligosaccharides extracts

8 citations , March 2022 in “Journal of The Taiwan Institute of Chemical Engineers”

Extracts from a type of brown seaweed can help promote hair growth.

Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp

research Stress-sensing in the human greying hair follicle: Ataxia Telangiectasia Mutated (ATM) depletion in hair bulb melanocytes in canities-prone scalp

14 citations , October 2020 in “Scientific reports”

Hair greying is linked to reduced ATM protein in hair cells, which protects against stress and damage.

research Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts

11 citations , July 2004 in “Journal of Investigative Dermatology”

Certain tyrosine kinases may regulate hair growth and could help develop hair loss treatments.

research Modulation of Hair Growth Promoting Effect by Natural Products

7 citations , December 2021 in “Pharmaceutics”

Natural products like plant extracts can help promote hair growth and could be used to treat hair loss.

research Hair growth-promotion effects at the cellular level and antioxidant activity of the plant-based extract Phyllotex™

7 citations , August 2021 in “Heliyon”

Phyllotex™ extract was found to significantly promote hair growth and protect against hair loss.

Mesenchymal Stem Cell Secretome for Dermatology Application: A Review

research Mechanotransduction unifies healthy non-diabetic wound healing over time by promoting a Cd14+/C1qa+ fibroblast subpopulation

April 2026 in “Journal of Investigative Dermatology”

Mechanotransduction aids healthy wound healing by promoting specific fibroblasts.

research Dermatosis associated with menopause

10 citations , January 2014 in “Journal of Mid-life Health”

Menopause can cause skin issues, and seeing a dermatologist helps.