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Did you mean Insulin-like Growth Factor Binding Proteins?

GlossaryInsulin-like Growth Factor Binding Proteins

regulate insulin-like growth factors' activity and availability

Insulin-like Growth Factor Binding Proteins (IGFBPs) are a group of proteins that bind to insulin-like growth factors (IGFs), which are hormones involved in growth and development. By binding to IGFs, IGFBPs regulate their activity, availability, and interaction with IGF receptors, thereby playing a crucial role in cell growth, differentiation, and metabolism.

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research Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1

37 citations , June 1996 in “Journal of cellular physiology”

Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.

research Study on Expression of Insulin-like Growth Factor-binding Protein-3and -5(IGFBP-3 and IGFBP-5)in the Skin of Inner Mongolia Cashmere Goat

January 2013 in “China Animal Husbandry & Veterinary Medicine”

IGFBP-5 likely plays a key role in goat hair growth.

research Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts**This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundacao Coordenacao de Aperfeicoa mento de Pessoal de Nivel Superior (CAPES), Universidade de Sao Paulo (Sao Paulo, Brazil).

43 citations , January 1999 in “Endocrinology”

Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.

research Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3

26 citations , June 2000 in “Journal of The American Academy of Dermatology”

Men with balding at age 45 had higher IGF-1 and lower IGFBP-3, suggesting these factors might be important in male pattern baldness.

research Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3

3 citations , June 2000 in “Journal of The American Academy of Dermatology”

Men with balding at age 45 had higher IGF-1 and lower IGFBP-3 levels, suggesting these factors might influence male pattern baldness.

The Association Between Low Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 With Hair Loss in Women: A Case-Control Study in Basrah, Iraq

research The Association between Low (or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case-Control Study in Basrah, Iraq

April 2026 in “European Journal of Medical and Health Research”

Women with hair loss had lower IGF-1 levels.

research Insulin-like growth factor 1 and hair growth

98 citations , November 1999 in “Dermatology Online Journal”

IGF-1 can boost hair growth by promoting cell growth and preventing cell death.

research Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth

21 citations , January 2018 in “The Korean Journal of Physiology and Pharmacology”

Modified stem cells from umbilical cord blood can make hair grow faster.

Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

research Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts

20 citations , January 2019 in “Journal of dermatological science”

Male hormones indirectly affect skin cell development by increasing growth factor levels from skin fibroblasts.

Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD71 Positive Keratinocyte Cells

research Hair-Growth-Promoting Effect of Conditioned Medium of High Integrin α6 and Low CD 71 (α6bri/CD71dim) Positive Keratinocyte Cells

17 citations , February 2015 in “International Journal of Molecular Sciences”

A special mix from certain skin cells can help hair grow by making hair root cells grow faster and activating growth signals.

Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors to Improve Skin Regeneration

research Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors To Improve Skin Regeneration

5 citations , September 2019 in “ACS Applied Bio Materials”

The hydrogel with bioactive factors improves skin healing and regeneration.

research Subcutaneous injection of conditioned medium from photobiomodulation-treated adipose-derived stromal cells promotes hair growth and angiogenesis in mice

June 2025 in “Archives of Dermatological Research”

Light-treated cell medium boosts hair growth in mice.

Hair Growth-Promoting Activity of Citron Seed Oil: Induction of Premature Telogen-To-Anagen Transition of Hair Follicle in C57BL/6 Mouse Models

research Hair Growth-Promoting Activity of Citron Seed Oil: Induction of Premature Telogen-To-Anagen Transition of Hair Follicle in C57BL/6 Mouse Models

April 2021 in “Current Topics in Nutraceutical Research”

Citron seed oil may help prevent or treat hair loss by promoting hair growth and increasing hair density.

research (Neuro-)endocrinology of epithelial hair follicle stem cells

42 citations , March 2008 in “Molecular and Cellular Endocrinology”

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

20 citations , November 2020 in “Stem Cell Research & Therapy”

Enhanced stem cells from the placenta can help treat Graves' eye disease by stopping fat cell growth.

Intrauterine Botulinum Toxin A Administration Promotes Endometrial Regeneration Mediated by IGFBP3-Dependent OPN Proteolytic Cleavage in Thin Endometrium

research Intrauterine botulinum toxin A administration promotes endometrial regeneration mediated by IGFBP3-dependent OPN proteolytic cleavage in thin endometrium

9 citations , January 2023 in “Cellular and Molecular Life Sciences”

Botulinum toxin A can help improve thin endometrium and embryo implantation.

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

September 2020 in “Research Square (Research Square)”

Enhanced stem cells from the placenta can reduce fat buildup in eye tissue for Graves' disease.

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

August 2020 in “Research Square (Research Square)”

Enhanced stem cells can reduce fat buildup in eye tissue for Graves' disease.

Functionally Enhanced Placenta-Derived Mesenchymal Stem Cells Inhibit Adipogenesis in Orbital Fibroblasts With Graves’ Ophthalmopathy

research Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves’ ophthalmopathy

June 2020

Enhanced stem cells from the placenta can reduce fat cell formation in eye disease.

Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

research β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

research Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

20 citations , December 2020 in “Frontiers in Immunology”

The immune processes causing VKH and vitiligo are similar in dogs and humans.

Conditioned Media Obtained from Human Outer Root Sheath Follicular Keratinocyte Culture Activates Signalling Pathways That Contribute to Maintenance of Hair-Inducing Capacity and Increases Trichogenicity of Cultured Dermal Cells

research Conditioned media obtained from human outer root sheath follicular keratinocyte culture activates signalling pathways that contribute to maintenance of hair-inducing capacity and increases trichogenicity of cultured dermal cells

6 citations , July 2012 in “Experimental Dermatology”

The substance from human hair root cells can help maintain hair growth and make skin cells more capable of growing hair.

research Distinct tooth regeneration systems deploy a conserved battery of genes

September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Different fish use the same genes to regrow teeth.

Prevalence of Polycystic Ovaries in Women with Self-Reported Symptoms of Oligomenorrhoea and/or Hirsutism: Northern Finland Birth Cohort 1966 Study

research Prevalence of polycystic ovaries in women with self-reported symptoms of oligomenorrhoea and/or hirsutism: Northern Finland Birth Cohort 1966 Study

77 citations , March 2004 in “Human Reproduction”

Women with irregular periods and/or excessive body hair are more likely to have polycystic ovaries, and this condition is linked to higher health risks.

research Skin Deep and Deeper: Multiple Pathways in Basal Cell Carcinogenesis

5 citations , September 2010 in “Cancer Prevention Research”

The research suggests new treatments for skin cancer could target specific cell growth pathways.

research Beneficial effects of the conditioned medium of adipose tissue-derived stem cells on human follicular cells

January 2010 in “Seoul National University Open Repository (Seoul National University)”

The medium from stem cells in fat tissue may boost hair growth.

research Molecular Conversations and the Development of the Hair Follicle and Basal Cell Carcinoma

21 citations , September 2010 in “Cancer Prevention Research”

Overactive signaling in hair follicles can lead to skin cancer.

research Insulin-like growth factor-1: roles in androgenetic alopecia

27 citations , February 2014 in “Experimental Dermatology”

IGF-1 affects hair loss and could be a potential treatment.

Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

research Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

54 citations , November 2017 in “Scientific Reports”

The study found that certain microRNAs are higher in the cells and lower in the fluid of women with a specific type of polycystic ovary syndrome, and one microRNA could potentially help diagnose the condition.

research Effects of oxytocin on the hair growth ability of dermal papilla cells

October 2023 in “Scientific Reports”

Oxytocin may help hair grow by increasing hair growth-related genes and factors.