July 2025 in “International Journal of Trichology” Biological factors are crucial for developing new hair restoration treatments.
Current hair regeneration methods show promise but face challenges in maintaining cell effectiveness and creating the right environment for hair growth.
3 citations
,
June 2025 in “Stem Cell Research & Therapy” Hair follicle-derived melanocyte transplant could effectively treat vitiligo by restoring skin color.
130 citations
,
December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair follicle melanocytes die during hair regression.
63 citations
,
February 2017 in “ACS biomaterials science & engineering” Polydopamine is a safe, effective, and permanent hair dye that turns gray hair black in one hour.
61 citations
,
January 2011 in “PloS one” Notch signaling is essential for healthy skin and hair follicle maintenance.
20 citations
,
September 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” MMP-9 is essential for proper hair canal formation.
19 citations
,
December 2023 in “Journal of Investigative Dermatology” Scalp hair follicle microbes affect hair health and could be used for treatments.
17 citations
,
May 2014 in “Cell transplantation” Genetically modified stem cells from human hair follicles can lower blood sugar and increase survival in diabetic mice.
16 citations
,
March 2021 in “Frontiers in cell and developmental biology” A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.
13 citations
,
November 2022 in “Biomaterials Science” The microneedle patch effectively promotes hair regrowth by delivering miR-218.
6 citations
,
January 2005 in “Biology of Blood and Marrow Transplantation” Graft-versus-host disease occurs when donor immune cells attack the recipient's body, causing skin, gut, and liver damage.
4 citations
,
January 2022 in “Life” Tissue engineering could be a future solution for hair loss, but it's currently expensive, complex, and hard to apply in real-world treatments.
1 citations
,
August 2024 in “Heliyon” Hair follicle stem cells can become melanocytes to help treat skin depigmentation.
1 citations
,
January 2021 in “Processes” Researchers successfully grew horse skin cells that produce pigment from hair follicle samples.
December 2025 in “Biopolymers” Heat worsens damage in chemically treated hair, especially bleached and straightened hair.
Stress can cause hair loss and trigger autoimmunity by damaging hair follicle cells.
October 2025 in “Journal of Neurophysiology” BK and Kv4.2 channels help Merkel cells in rat whiskers sense touch.
June 2025 in “Clinical Cosmetic and Investigational Dermatology” Gray hair can potentially be managed or reversed with treatments that boost melanin production and address nutritional deficiencies.
May 2025 in “International Journal of Molecular Sciences” Exosomes from rat hair follicle stem cells may help heal wounds and regenerate skin.
October 2023 in “Biomaterials” Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.
February 2023 in “Journal of Advanced Research” A new method using Platelet-rich Plasma (PRP) in a microneedle can promote hair regrowth more efficiently and is painless, minimally invasive, and affordable.
3 citations
,
June 2023 in “Plastic & Reconstructive Surgery” The 2-step surgery effectively treats stable follicular vitiligo with high patient satisfaction and no major complications.
November 2025 in “Cosmetics” Autologous Micrografting Technology effectively improves hair growth and is a safe, promising option for hair restoration.
338 citations
,
July 2009 in “Development” Sox2-positive cells determine specific hair follicle types in mammals.
12 citations
,
January 2021 in “Journal of Investigative Dermatology” Hair follicle studies suggest that maintaining telomere length could help treat hair loss and graying, but it's uncertain if mouse results apply to humans.
1 citations
,
November 2023 in “iScience” A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.
8 citations
,
January 2020 in “PeerJ” Alopecia Areata causes significant structural and compositional changes in hair.
Nanocarriers with plant extracts show promise for safe and effective hair growth treatment.
321 citations
,
January 2012 in “Cell stem cell” TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.