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Rat skin takes up and processes testosterone differently than other organs, with testosterone being more important for the skin than its metabolite 5α-DHT.

Scientists successfully created and analyzed the structure of a part of the human androgen receptor with specific modulators and a peptide to understand how it binds differently in various tissues.

Fibroblasts help understand androgen resistance at the cellular level.

Androgen receptor activity is influenced by hormones, co-factors, modifications, and mutations.

Anabolic androgenic steroids can increase cancer risk and disrupt hormones.

Testosterone and its byproducts help support male sexual behavior through different pathways in the brain and body.

Increased DHT formation in skin can cause hair loss, acne, and excessive hair growth, and antiandrogens might treat these conditions.

A new method helps detect androgen receptor movement in cells, aiding research on hair loss treatments.

Androgen signaling reduces Wnt activity, affecting prostate stem cell growth.

Male hormones promote hair cell growth by using a growth factor from nearby skin cells.

Blocking a specific enzyme in male rat fetuses leads to the development of nipples and feminized genitalia.

Mutations in the androgen receptor gene cause Androgen Insensitivity Syndrome, affecting sexual development.

The study found that androgen receptors in skin cells mainly affect the focal adhesion pathway and control the caveolin-1 gene, with implications for new treatments for related diseases.

The androgen receptor's shape-changing ability helps it function but can lead to cancer treatment resistance.

Androgen receptor inactivation delays skin cancer onset and reduces incidence in mice, with gender differences in susceptibility.

The research identified genes and non-coding RNAs in cells that could be affected by testosterone, which may help understand hair loss and prostate cancer.

Human keratinocytes do not naturally respond to androgens.

Testosterone affects androgen receptors and lipid storage in cells, while DHEA does not convert to testosterone or affect these receptors in the same way.

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

A boy's early puberty caused by a testicular tumor returned to normal after surgery.

Scientists restored fertility in male mice lacking a key fertility gene by using a modified gene.

Masculinization in affected individuals occurs gradually after puberty due to hormone changes.

Epitestosterone may counteract testosterone's effects and has roles in body processes like prostate growth and hair distribution.

Androgen receptor overexpression can increase prostate cancer cell growth even without hormones.

Testosterone makes XX skin more like male skin by changing its structure and cell makeup.

Individuals with this condition often develop male traits and identities at puberty despite being raised as females.

Testosterone is important for male sexual traits, reproduction, muscle and bone health, blood production, and metabolism, and works both directly and after being changed into other hormones.

Glioblastoma cells can make androgens, which might help the tumor grow.