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Androgens affect skin conditions like acne and hair loss through specific biochemical pathways.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Hair loss, prostate size, and urinary issues are related due to androgen effects.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Androgens increase norepinephrine release, promoting smooth muscle growth in male sex organs, which may contribute to benign prostatic hypertrophy.

Mutations in the androgen receptor gene cause androgen insensitivity, leading to female traits in genetically male individuals.

Testosterone works in different ways, including direct interaction with its receptor, conversion to other hormones for specific effects on genitalia, hair, bones, and muscle, and changes in body fat and sexual function when low.

Androgens can affect glucocorticoid signaling in specific mouse brain areas.

A specific metabolite, not a receptor protein, triggers the production of certain kidney enzymes, but this process is disrupted in mice with a mutation causing testicular feminization.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Genetic defects in androgen production are linked to male developmental disorders and are improving treatment understanding.

Insufficient androgen action in male fetuses can cause genital development issues due to genetic mutations or environmental chemicals.

Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.

Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.

Affected males are born with ambiguous genitalia, raised as females, but develop male traits at puberty due to enzyme deficiency.

A short male anogenital distance may indicate incomplete masculinization due to disrupted androgen action.

Human prostate cells produce more WISP1/CCN4 when there's not enough oxygen.

Early androgen exposure affects hormone receptor expression in adult female rats' brains, but not in males.

The study created a new method to test drugs that affect hormone processing in skin.

A new mutation linked to partial Androgen Insensitivity Syndrome and prostate cancer was found in a patient unhappy with their female gender assignment.

DHT deficiency may disrupt rat epididymis function by affecting estrogen receptors.

Androgens reduce THY1 in skin cells, leading to less fat, more fibrosis, and worse healing in males.

DHT enhances androgen receptor activity more than testosterone, and MAGE-11 influences this activity through specific interactions.

Male children's genital development issues can be caused by genetic mutations or environmental factors affecting hormone action.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

Omega-6 fats in certain cells boost male hormone production.