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GlossaryIntradermal Injections

involves injecting medication into the skin's dermis layer

Intradermal injections (ID injections) involve administering a small amount of medication or substance directly into the dermis, the layer of skin just below the outermost layer (epidermis). This method is commonly used for allergy tests and tuberculosis screening because it allows for a slow absorption of the substance and a localized reaction that can be easily observed.

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Intradermal Injections of a Hair Growth Factor Formulation for Enhancement of Human Hair Regrowth: Safety and Efficacy Evaluation in a First-in-Man Pilot Clinical Study

research Intradermal injections of a hair growth factor formulation for enhancement of human hair regrowth – safety and efficacy evaluation in a first-in-man pilot clinical study

17 citations , February 2018 in “Journal of Cosmetic and Laser Therapy”

The QR 678 hair growth treatment was safe and effective for hair regrowth in men and women.

research Observation on cadavers and through ultrasonography using a 2 mm needle length for intradermal injections

11 citations , November 2023 in “Skin Research and Technology”

A 2 mm needle is effective and precise for skin injections.

research Intradermal injections with 0.5% minoxidil for the treatment of female androgenetic alopecia: A randomized, placebo‐controlled trial

7 citations , December 2020 in “Dermatologic Therapy”

Injections with 0.5% minoxidil effectively treat female hair loss, increasing hair density and thickness.

research Platelet-rich plasma in alopecia areata: intradermal injection versus topical application with transepidermal delivery via either fractional carbon dioxide laser or microneedling

5 citations , January 2020 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)”

Injecting platelet-rich plasma or applying it with a laser or microneedling can treat hair loss effectively. The laser and microneedling methods cause less pain.

research Adverse Reactions Following Intradermal Injection of Exosome‐Based Formulations: A Case Series

4 citations , October 2025 in “Journal of Cosmetic Dermatology”

Unregulated exosome-based injections can cause severe skin reactions and scarring.

research Intradermal Botulinum Toxin A Injection for Scalp Sebum Secretion Regulation: A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Prospective Study in Chinese Subjects

4 citations , August 2022 in “Aesthetic Surgery Journal”

Botulinum toxin A injections reduce scalp oil for up to 3 months.

Evaluation of Efficacy of Intradermal Injection Therapy vs Derma Roller Application for Administration of QR678 Neo Hair Regrowth Formulation for the Treatment of Androgenetic Alopecia—A Prospective Study

research Evaluation of efficacy of intradermal injection therapy vs derma roller application for administration of QR678 Neo ^® hair regrowth formulation for the treatment of Androgenetic Alopecia—A prospective study

4 citations , April 2021 in “Journal of Cosmetic Dermatology”

Intradermal injections improve hair density and thickness better, while derma roller is more convenient.

research Efficacy of intradermal minoxidil 5% injections for treatment of patchy non-severe alopecia areata

4 citations , July 2020 in “Journal of Dermatological Treatment”

Minoxidil injections can speed up hair regrowth in non-severe patchy hair loss, but combining it with steroids doesn't improve results.

research Intradermal Local Injection of Autologous Cell‐Free Fat Extract for the Treatment of Refractory Postinflammatory Hyperpigmentation

2 citations , January 2023 in “Dermatologic Therapy”

CEFFE injections effectively and safely improve postinflammatory hyperpigmentation.

Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-Month Randomized Trial

research Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection (Mesotherapy) for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-month Randomized Trial

1 citations , January 2010

Mesotherapy is more effective than topical spray for female hair loss treatment.

research Efficacy of Dutasteride Intradermal Injection in The Treatment of Androgenetic Alopecia

January 2026 in “International Journal of Dermatology Venereology and Leprosy Sciences”

Intradermal dutasteride effectively and safely improves hair growth in early-stage androgenetic alopecia.

research Platelet-rich plasma for androgenetic alopecia: intradermal injection or microneedle delivery?

April 2025 in “Journal of Cosmetic and Laser Therapy”

Microneedle delivery of platelet-rich plasma may be slightly better for hair regrowth than intradermal injection.

Intradermal Injection in Balding Region Versus Intramuscular Injection in Surrounding Muscles: A Split-Scalp, Randomized Trial on Botulinum Toxin for Androgenetic Alopecia

research Intradermal Injection in Balding Region Versus Intramuscular Injection in Surrounding Muscles: A Split-Scalp, Randomized Trial on BoNT for Androgenetic Alopecia

June 2024 in “Dermatology and therapy”

Intramuscular injections improved hair density more than intradermal injections for treating hair loss.

research Intradermal injection of platelet-rich plasma for periorbital wrinkles: A review

March 2024 in “Intisari Sains Medis”

PRP injections improve periorbital wrinkles and show promise as a treatment.

research A Single Intradermal Injection of Autologous Adipose-Tissue-Derived Stem Cells Rejuvenates Aged Skin and Sharpens Double Eyelids

July 2023 in “Journal of personalized medicine”

Injecting a person's own fat stem cells into their skin can make it look younger and improve double eyelids for over a year.

research Efficacy and safety of intradermal injection of some therapeutics in treatment of androgenetic alopecia: Comparative study

July 2023 in “International journal of dermatology, venereology and leprosy sciences”

Intradermal injections might work better for common hair loss than other treatments.

research Intradermal Injection of Bleomycin Shows Preliminary Evidence of Dermal Fibrosis in a Mouse Model

June 2024 in “Georgetown Scientific Research Journal”

Bleomycin injections in mice cause skin thickening and hair loss.

research 022 Randomized, double-blind, placebo-controlled, single-centre, phase I safety study of intradermal injections of autologous fibroblasts isolated from the non-bulbar dermal sheath of the hair follicle to treat skin aging

September 2017 in “Journal of Investigative Dermatology”

RCS-01 is safe and may help rejuvenate aging skin.

research Anhidrotic effect of intradermal injections of botulinum toxin—A comparison of different products and concentrations

May 2008 in “Toxicon”

Different botulinum toxin products and concentrations can effectively reduce sweating, itching, bladder pressure, hair loss, and muscle spasms.

Phase I/IIa Clinical Trial for the Treatment of Androgenetic Alopecia Using Intradermal Injections of Cultured Autologous Dermal Sheath Cup Cells

research 281 Phase I/IIa clinical trial for the treatment of androgenetic alopecia using intradermal injections of cultured autologous dermal sheath cup cells

September 2017 in “Journal of Investigative Dermatology”

Injections of special skin cells showed potential in treating hair loss, with some participants experiencing increased hair density.

research Treatment Effects of Intradermal Botulinum Toxin Type A Injection on Alopecia Areata

24 citations , December 2010 in “Dermatologic surgery”

Botulinum toxin type A injections are not effective for severe alopecia areata.

research P latelet rich plasma application by dermapen microneedling and intradermal point‐by‐point injection methods, and their comparison with clinical findings and trichoscan in patients with androgenetic alopecia

3 citations , October 2021 in “Dermatologic Therapy”

PRP with microneedling improves hair growth and patient satisfaction more than injections for androgenetic alopecia.

research Efficacy of platelet rich plasma intradermal injections for androgenetic alopecia treatment in males: A Before and after study

August 2020 in “Actas Dermo-Sifiliográficas”

PRP injections improve hair density in men with hair loss, with few short-term side effects.

research Platelet rich plasma intradermal injections the area of expression of CD34 and B-catenin in males with androgenetic alopecia 11th World Congress for Hair Reserch

January 2019 in “11th World congress for hair research”

research Unexpected refractory hypotension following intradermal minoxidil injection

March 2023 in “Clinical Toxicology”

Clinical, Trichoscopic, and Folliscopic Identification of the Impact of Metabolic Syndrome on the Response to Intradermal Dutasteride 0.02% Injection in Patients with Female Pattern Hair Loss: A Prospective Cohort Study

research Clinical, trichoscopic, and folliscopic identification of the impact of metabolic syndrome on the response to intradermal dutasteride 0.02% injection in patients with female pattern hair loss: a prospective cohort study

2 citations , December 2019 in “Journal of Dermatological Treatment”

Metabolic syndrome reduces effectiveness of hair loss treatment.

research Reply to: Platelet‐rich plasma application by dermapen microneedling and intradermal point‐by‐point injection methods, and their comparison with clinical findings and Trichoscan in patients with androgenetic alopecia

September 2022 in “Dermatologic Therapy”

research Local Injection of Steroids and Hair Regrowth in Alopecias

57 citations , December 1960 in “Archives of Dermatology”

Steroid injections can help regrow hair in some alopecia cases.

research Effects of Intradermally Injected and Topically Applied Mouse Epidermal Growth Factor on Wool Growth, Skin and Wool Follicles of Merino Sheep

36 citations , June 1988 in “Australian Journal of Biological Sciences”

Mouse epidermal growth factor injections in sheep affected wool growth and skin, but saline did not.

research Hair loss at injection sites of mesotherapy for alopecia

18 citations , February 2017 in “Journal of Cosmetic Dermatology”

Mesotherapy for hair loss can sometimes cause more hair loss and scarring.