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A new pain-measuring system using sensors and AI can effectively detect pain in mice, which may help assess pain in humans and develop treatments.

TRPV3 in skin cells causes inflammation and cell death.

Sphingosine 1-phosphate helps control mechanical pain.

Dopamine receptors in the brain influence itch-related scratching behavior.

Methylene blue staining effectively highlights detailed nerve structures in rat fur.

TRPA1 and TRPV1 channels don't affect mechanotransduction in rat sinus hair follicles.

Increasing neurotrophin 4 in skin boosts nerve endings but not sensory neuron count.

The TRPV3 channel structure changes linked to severe itch and hyperkeratosis were identified using cryo-EM.

Sphingosine 1-phosphate and its receptor S1PR3 are key in controlling mechanical pain.

Itchy keloids on the chest are linked to more nerve fibers and substance P.

Neuropathic pruritus is a commonly overlooked and wrongly diagnosed type of chronic itching that is hard to treat.

Improving nerve and immune interactions may help heal chronic wounds.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

Certain substances can help skin cells become anti-inflammatory, aiding in tissue repair.

The placebo microneedle stamp didn't penetrate skin and caused less pain, but blinding was only effective for those with low skin sensitivity.

New microneedles deliver drugs through the skin accurately and effectively.

Microneedles offer a painless way to deliver drugs effectively but need more research before they can be widely used.

Microneedle patches offer painless, effective drug delivery and are suitable for all ages.

Low-dose naltrexone might be a cheap and effective additional treatment for hair loss with scalp discomfort due to its anti-inflammatory effects and few side effects.

Nociplastic pain is a complex, heritable trait with genetic links to chronic and neuropathic pain.

Activating TRPA1 reduces scarring and promotes tissue regeneration.

Polymer microneedles are a promising, painless alternative to traditional needles for delivering drugs through the skin.

TRPV4 channel affects skin health and could be a target for treating skin disorders.

Lysophosphatidic acid affects sensory neurons and may cause neuropathic pain and itch.

Chronic scalp pain in trichodynia involves both body-wide and localized increased pain sensitivity.

Nanoparticle-embedded microneedles improve drug delivery through the skin but face challenges in stability and safety.

The ointment effectively treats neurodermatitis and chronic eczema without causing skin irritation.